[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613307":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":59,"collaborators":10,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":10,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":82,"overallStatus":97,"whyStopped":10,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Beijing Anzhen Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ACS with MVD Cohort",null,"A single prospective, observational cohort of 200 patients presenting with Acute Coronary Syndrome (ACS) and multi-vessel disease (MVD). This single cohort will be pre-stratified at enrollment into two groups for comparative analysis: 1) STEMI (N≈100) and 2) High-Risk NSTEMI (N≈100). All participants undergo the identical longitudinal assessment.",[13,14,15],"Diagnostic Test: IVUS-based Fractional Flow Reserve (UFR)","Diagnostic Test: Invasive Coronary Physiology Measurement (FFR\u002FRFR\u002FIMR)","Diagnostic Test: Cardiac Magnetic Resonance (CMR)",[17,22,26],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"DIAGNOSTIC_TEST","IVUS-based Fractional Flow Reserve (UFR)","UFR is a \"virtual\" fractional flow reserve calculated from Intravascular Ultrasound (IVUS) images using computational fluid dynamics.\n\nIn this study, it is calculated from IVUS runs of the Non-Culprit Vessel (NCV) performed at the T0 (Acute) procedure. This T0 UFR value is the primary diagnostic test being evaluated against the T1 (30-day) pFFR gold standard. UFR will also be assessed at the T2 (1-year) follow-up.",[9],{"type":18,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"Invasive Coronary Physiology Measurement (FFR\u002FRFR\u002FIMR)","Invasive physiological measurements are performed using a standard pressure-sensing guidewire.T0 (Acute): FFR, RFR, and IMR are measured in the Non-Culprit Vessel (NCV) and the post-PCI Culprit Vessel (CV).T1 (30-Day): FFR and RFR are measured in the NCV. This T1 pFFR (threshold\\\u003C 0.80) serves as the gold standard comparator for the primary endpoint.T2 (1-Year): FFR is reassessed in the CV and any untreated NCV.",[9],{"type":18,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"Cardiac Magnetic Resonance (CMR)","The scan is performed prior to discharge to quantify myocardial injury, including infarct size, Left Ventricular Ejection Fraction (LVEF), and the extent of Microvascular Obstruction (MVO). CMR data serves as the \"tissue\" component for the secondary 'structure-function-tissue' coupling analysis.",[9],[31],{"name":32,"affiliation":5,"role":33},"Hai Gao, MD, PHD","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Lin Wang, MD PHD","CONTACT","008613552122249","linwang5215@163.com",[41],{"facility":42,"status":10,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Beijing Anzhen Hospital, Capital Medical University","Beijing","Beijing Municipality","100029","China","CN",{"type":49,"coordinates":50},"Point",[51,52],116.39723,39.9075,{"lat":52,"lon":51},[55],{"name":56,"role":37,"phone":57,"phoneExt":10,"email":58},"WEI LI, PHD","008613263369171","liwei_907@126.com",{"type":33,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Hai Gao","Chief Physician","100613307","for-patients-with-myocardial-infarction-and-multiple-vessel-testing-if-ultrasound-ufr-can-guide-all-needed-treatment-in-one-procedure-avoiding-a-return-hospital-visit-for-a-second-operation-100613307",false,"NCT07264881","For Patients With Myocardial Infarction and Multiple Vessel: Testing if Ultrasound (UFR) Can Guide All Needed Treatment in One Procedure, Avoiding a Return Hospital Visit for a Second Operation.","A Prospective, Longitudinal, Multi-modal Study Evaluating the Utility of Acute Phase UFR (IVUS-FFR) to Predict Functional Significance in the Stable Phase for Patients With Acute Coronary Syndrome (ACS)","ACT-EVOLVE","Inclusion Criteria:\n\n* Age \\>18 years, any sex.\n* The participant is able to understand the study procedures and provides voluntary written informed consent.\n* Diagnosed with Acute Coronary Syndrome (ACS) and meets the criteria for one of the two pre-specified cohorts:\n* STEMI Cohort: Symptom onset \\\u003C 12 hours with ECG findings of ST-segment elevation myocardial infarction.\n* High-Risk NSTEMI Cohort: Meets at least one of the following: GRACE score \\> 140, dynamic ECG changes (ST-T), or significant Troponin elevation.\n* Has undergone successful emergency PCI of the Culprit Vessel (CV), with post-PCI TIMI flow Grade 3.\n* Coronary angiography confirms Multi-vessel Disease (MVD), defined as: at least one Non-Culprit Vessel (NCV) with a moderate stenosis (visual diameter stenosis 50-90%).\n* The target NCV (50-90% stenosis) is deemed by the investigator to be anatomically suitable for IVUS and pressure-wire assessment.\n* The participant agrees and is confirmed to be willing and able to strictly adhere to the protocol and complete all required invasive procedures, CMR scans, and follow-ups at the four timepoints (T0, T-CMR, T1, T2).\n\nExclusion Criteria:\n\n* Presence of cardiogenic shock on presentation, or persistent hemodynamic instability despite successful PCI of the culprit vessel.\n* Known severe allergy to iodinated contrast media or gadolinium-based contrast agents (used for CMR).\n* Female participants who are pregnant, breastfeeding, or planning pregnancy within the 1-year study period.Unprotected left main coronary artery disease (stenosis \\\u003C50%) requiring intervention.\n* Prior history of Coronary Artery Bypass Grafting (CABG) surgery.The target NCV has received prior PCI (e.g., existing stent) or surgical revascularization.\n* The target NCV is a Chronic Total Occlusion (CTO).\n* Severe renal insufficiency (eGFR \\\u003C 30 ml\u002Fmin\u002F1.73m²) or currently undergoing chronic dialysis.\n* Standard contraindications to CMR examination (e.g., claustrophobia, non-MRI-compatible metallic implants\u002Fpacemakers).\n* Known presence of a severe non-cardiac comorbidity with an expected lifespan of \\\u003C 12 months (e.g., advanced malignancy).\n* Known severe hematological disease (e.g., severe anemia, active bleeding, thrombocytopenia \\\u003C 70 x 10⁹\u002FL) rendering the participant unsuitable for multiple invasive procedures.\n* Inability to provide informed consent or comply with the complex longitudinal follow-up protocol due to psychiatric, cognitive, or other reasons.\n* Currently participating in another interventional (drug or device) clinical study.\n* Any other condition which, in the investigator's opinion, makes the participant unsuitable for enrollment (e.g., severe valvular heart disease, cardiomyopathy).","ALL","18 Years",{"count":73,"type":74},200,"ESTIMATED","OBSERVATIONAL","Brief Summary The Purpose of the Study : The purpose of this study is to find a safe and reliable \"one-stop\" solution for treating heart attack patients who have multiple blocked arteries. Currently, doctors face a dilemma: Testing these other blockages during the heart attack procedure is often unreliable.\n\nThe most accurate method requires asking the patient to return 30 days later for a second invasive procedure, which is a significant burden.\n\nThe Study's Hypothesis : We are testing a new tool called UFR, which uses ultrasound images to measure blockages. Our hypothesis (or \"educated guess\") is that this new UFR tool is not affected by the body's stress during a heart attack and can provide a true, reliable measurement right away.\n\nThe Question the Study is Trying to Answer ： The main question this study is trying to answer is: Can the new \"one-stop\" UFR tool, used during the initial heart attack procedure, accurately predict which blockages are truly serious... thereby eliminating the need for patients to return for a second procedure 30 days later? Researchers will also follow 200 patients for one year, using advanced scans (like UFR, standard tests, and MRI), to better understand how the heart and arteries heal and change over time.",[78,79,80,81],"Microvascular Obstruction (MVO)","Multivessel Coronary Artery Disease","ACS (Acute Coronary Syndrome)","ST Elevation Myocardial Infarction (STEMI)",[83,84,85,86,87,88,89,90,91,92,93,94,95,96],"Acute Coronary Syndrome","Fractional Flow Reserve,","Intravascular Ultrasound","Virtual Fractional Flow Reserve","Functional Drift","Coronary Microvascular Dysfunction","Index of Microcirculatory Resistance","Non-Culprit Vessel","ST Elevation Myocardial Infarction","Non-ST Elevation Myocardial Infarction","Cardiac Magnetic Resonance","Microvascular Obstruction","Staged Revascularization","Computational Fluid Dynamics","NOT_YET_RECRUITING","2025-11-24",{"date":100,"type":101},"2025-12-04","ACTUAL",{"date":103,"type":74},"2025-12-02",{"date":105,"type":74},"2028-06-22",{"name":5,"class":6},1]