[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573762":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":24,"locations":30,"responsibleParty":50,"collaborators":23,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":23,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":23,"overallStatus":33,"whyStopped":23,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Wageningen University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Participants with Type 2 Diabetes","EXPERIMENTAL","Two days of standardized meal consumption",[13],"Behavioral: Forearm immobilization",{"label":15,"type":10,"description":11,"interventionNames":16},"Participants without Type 2 Diabetes",[13],[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"BEHAVIORAL","Forearm immobilization","Two days of forearm immobilization",[9,15],null,[25],{"name":26,"role":27,"phone":28,"phoneExt":23,"email":29},"Marlou Dirks, PhD","CONTACT","+31 317 480 100","marlou.dirks@wur.nl",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Wageningen University and Research","RECRUITING","Wageningen","Gelderland","6708WD","Netherlands","NL",{"type":40,"coordinates":41},"Point",[42,43],5.66667,51.97,{"lat":43,"lon":42},[46],{"name":47,"role":27,"phone":48,"phoneExt":23,"email":49},"Human and Animal Physiology","+31 (0)317 484 136","office.hap@wur.nl",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Marlou Dirks","Assistant Professor","100573762","forearm-immobilization-in-t2d-100573762",false,"NCT06750497","Forearm Immobilization in T2D","The Impact of Short-term Forearm Immobilization on Forearm Muscle Glucose and Amino Acid Metabolism of Volunteers With or Without Type 2 Diabetes","FIT2D","Inclusion criteria\n\n* Males and females with or without diagnosed type 2 diabetes\n* Use lifestyle changes, metformin, gliclazide, or a combination thereof as oral glucose-lowering treatments for T2D\n* Aged 18-80 years at the time of signing informed consent\n* 18.5 ≥ BMI ≤ 35 kg·m2\n\nExclusion criteria\n\n* Type 1 or a genetic form of diabetes\n* Any diagnosed cardiovascular (heart) disease or high blood pressure (≥160 mmHg systolic and\u002For ≥100 mmHg diastolic)\n* Chronic use of any prescribed or over-the-counter pharmaceuticals (excluding oral contraceptives and contraceptive devices) that interact with muscle substrate metabolism (e.g. selective serotonin reuptake inhibitors)\n* Consumption of a low-carbohydrate diet\n* Smoking or chewing tobacco\n* Known anaemia\n* Regular use of dietary protein and\u002For amino acid supplements (\\>3 times per week)\n* Currently involved in a structured progressive resistance training program (\\>3 times per week)\n* A personal or family history of thrombosis (clots)\n* Any previous motor disorders or inborn errors in muscle and\u002For lipid metabolism\n* History of kidney disease\n* History of liver disease\n* Pregnant or breastfeeding\n* History of any drug or alcohol abuse in the past two years\n* Claustrophobia\n* Unable to give consent",true,"ALL","18 Years","80 Years",{"count":67,"type":68},26,"ESTIMATED","INTERVENTIONAL",[71],"NA","The aim of the present study is to assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics in individuals with T2D compared with a control group with normoglycaemia.",[74,75],"Healthy","Type 2 Diabetes","2026-07-01",{"date":78,"type":79},"2026-07-02","ACTUAL",{"date":81,"type":79},"2024-11-21",{"date":83,"type":68},"2027-04-30",{"name":5,"class":6},1]