[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611665":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":45,"responsibleParty":64,"collaborators":25,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":25,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":48,"whyStopped":25,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Egas Moniz - Cooperativa de Ensino Superior, CRL","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Fractal Cueing, Then Isochronous Cueing","EXPERIMENTAL","Participants exposed to 12-minute treadmill walking synchronized to a visual fractal metronome individualized to stride time variability. After a washout period of 1 week, participants will be exposed to 12-minute treadmill walking synchronized to a visual isochronous metronome with fixed stride time.",[13,14],"Device: Fractal Cueing","Device: Isochronous Cueing",{"label":16,"type":10,"description":17,"interventionNames":18},"Isochronous Cueing, then Fractal cueing","Participants exposed to 12-minute treadmill walking synchronized to a visual isochronous metronome with fixed stride time. After a washout period of 1 week, participants will be exposed to 12-minute treadmill walking synchronized to a visual fractal metronome individualized to stride time variability.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Fractal Cueing","Walking synchronized to a visual fractal metronome.",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Isochronous Cueing","Walking synchronized to a visual Isochronous metronome.",[9,16],[31],{"name":32,"affiliation":33,"role":34},"João R Vaz, PhD","Egas Moniz school of Health & Science","STUDY_DIRECTOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Inês D Ribeiro, MSC Student","CONTACT","(+351) 964 544 607","115360@alunos.egasmoniz.edu.pt",{"name":42,"role":38,"phone":43,"phoneExt":25,"email":44},"Catarina S Pino, MSC Student","(+351) 937 780 194","118878@alunos.egasmoniz.edu.pt",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Egas Moniz School of Health & Science","RECRUITING","Almada","Monte de Caparica","2829-511","Portugal","PT",{"type":55,"coordinates":56},"Point",[57,58],-9.1569,38.67902,{"lat":58,"lon":57},[61],{"name":62,"role":38,"phone":25,"phoneExt":25,"email":63},"Inês Gomes","rso.cieem@egasmoniz.edu.pt",{"type":65,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100611665","fractal-vs-isochronous-cueing-in-athletes-after-acl-reconstruction-100611665",false,"NCT07243535","Fractal vs Isochronous Cueing in Athletes After ACL Reconstruction","Comparison Between a Session of Walking Synchronized to Fractal- VS Isochronous-Based Cues on Gait Variability and Corticospinal Measures in Athletes With a Reconstructed Anterior Cruciate Ligament: A Crossover Randomized Controlled Trial","SyncGait","Inclusion Criteria:\n\n* Undergone unilateral ACL reconstruction less than 2 years ago;\n* Have medical release for the full load on the injury limb for at least 2 weeks;\n* Be independently pain-free walking;\n* Being sports athletes according to an athlete description: Training regularly to improve performance, actively participating in competitions or formally registering in a sports federation or association;\n* Must be able to understand and perform the requested task.\n\nExclusion Criteria:\n\n* Participants with previous surgery on either knee;\n* Those with more than 3 months between ACL injury and surgery;\n* More than 2 weeks between surgery and the start of physical therapy;\n* Had another musculoskeletal injury in the lower limb within the past 6 months;\n* Another musculoskeletal surgery within the past 18 months;\n* Participants with a history of movement system pathologies, such as nervous system, cardiovascular, pulmonary, integumentary, or endocrine conditions;\n* Participants with vestibular or somatosensory system pathologies or visual impairments limiting their ability to see the metronome required for the task;\n* Use of medications that could affect locomotion and balance.","ALL","15 Years","35 Years",{"count":78,"type":79},36,"ESTIMATED","INTERVENTIONAL",[82],"NA","Anterior cruciate ligament (ACL) injuries are among the most prevalent and functionally limiting knee injuries in sports, particularly those that involve pivoting movements. Despite advancements in surgical reconstruction and physical rehabilitation, many athletes continue to exhibit persistent motor control deficits and increased gait variability, both of which are closely linked to a heightened risk of re-injury and long-term joint degeneration. These deficits arise from biomechanical impairments and disrupt proprioceptive input that requires cortical reorganization, contributing to maladaptive neuroplasticity. However, conventional rehabilitation strategies often overlook this neural dimension. Recent findings emphasize the importance of fostering motor variability and promoting neuroplasticity through external focus strategies, including sensorimotor synchronization. While isochronous cues, an invariant stimulus, are commonly used, they do not reflect the natural fluctuations of healthy gait and may reduce its complexity. Fractal-based cues, in contrast, introduce structured variability resembling the natural dynamics of locomotion and have been shown to restore gait complexity in clinical populations. However, no study has yet explored their acute effects on gait variability and corticospinal function following ACL reconstruction (ACLR). This crossover randomized controlled trial aims to compare the acute effects of a single session of treadmill walking synchronized to either fractal or isochronous-based visual cues on gait variability and corticospinal measures in athletes with ACLR. The investigators hypothesize that fractal-based cueing will acutely restore gait variability and enhance corticospinal excitability, evidenced by increased corticospinal excitability and intracortical facilitation, and reduced short-interval intracortical inhibition, thus promoting adaptive neuroplasticity. Conversely, isochronous cueing is expected to maintain or decrease gait complexity without improving corticospinal measures. This study may provide insights that could be highly valuable as a way to promote neuroplasticity and optimize gait rehabilitation after ACLR, also allowing an objective quantification and aiming to restore variability to levels close to those observed in healthy individuals, thus contributing to reducing the re-injury rate.",[85,86,87],"Anterior Cruciate Ligament Reconstruction","Anterior Cruciate Ligament Reconstruction Rehabilitation","Athlete",[89,90,91,92,93],"Complexity","Excitability","Metronome","Neuroplasticity","Rehabilitation","2025-11-17",{"date":96,"type":97},"2025-11-24","ACTUAL",{"date":99,"type":97},"2025-10-03",{"date":101,"type":79},"2026-02",{"name":5,"class":6},1]