[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556275":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":30,"centralContacts":35,"locations":46,"responsibleParty":70,"collaborators":72,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":40,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":40,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":40,"overallStatus":49,"whyStopped":40,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Egymedicalpedia","INDUSTRY",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A","ACTIVE_COMPARATOR","About 15 cases will receive sessions with fractional Er: YAG laser every 3 weeks followed by application of topical 4% (HQ) cream.",[13],"Drug: Tranexamic acid injection",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B","About 15 cases will receive sessions of intradermal injection of tranexamic acid on the melasma site every 3 weeks concurrently with the application of topical 4% HQ cream every night. The injections will be done using an insulin syringe with a dilution of the tranexamic acid",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Group C","About 15 cases will receive oral tranexamic acid 500mg tablet once daily for three months. And will also be asked to apply a thin layer of topical HQ 4% cream on the hyperpigmented areas once every night.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","Tranexamic acid injection","to evaluate and compare efficacy of:\n\n* Fractional Er: YAG laser combined with topical hydroquinone.\n* Intradermal injection of tranexamic acid combined with topical hydroquinone cream.\n* Oral administration of tranexamic acid combined with topical hydroquinone cream. In treating refractory melasma.",[9,15,19],[29],"Fractional erbium YAG laser",[31],{"name":32,"affiliation":33,"role":34},"Moustafa Adam Ali El Taieb, Professor","Dermatology, Venereology and Andrology.Faculty of Medicine, Aswan University","STUDY_CHAIR",[36,42],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Heba Allah Mohamed Mustafa, Resident","CONTACT","+201151182890",null,"HebaAllah1704336@aswu.edu.eg",{"name":43,"role":38,"phone":44,"phoneExt":40,"email":45},"Moustafa Adam Ali El Taieb, professor","+201092991101","moustafa.eltaib@aswu.edu.eg",[47],{"facility":48,"status":49,"city":50,"state":40,"zip":40,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Aswan University hospitals","RECRUITING","Aswān","Egypt","EG",{"type":54,"coordinates":55},"Point",[56,57],32.89942,24.09082,{"lat":57,"lon":56},[60,64,68],{"name":61,"role":38,"phone":62,"phoneExt":40,"email":63},"Mahmoud Ahmed Ali, M.D","+201002364902","dr.mahmoudali@aswu.edu.eg",{"name":65,"role":38,"phone":66,"phoneExt":40,"email":67},"Mohamed Amer Ahmed Abdellatif, M.D","+201060394083","mohammed.abdellatif@aswu.edu.eg",{"name":37,"role":69,"phone":40,"phoneExt":40,"email":40},"PRINCIPAL_INVESTIGATOR",{"type":71,"investigatorFullName":40,"investigatorTitle":40,"investigatorAffiliation":40,"oldNameTitle":40,"oldOrganization":40},"SPONSOR",[73],{"name":74,"class":75},"Aswan University","OTHER","100556275","fractional-erbium-yag-laser-vs-intradermal-and-systemic-tranexamic-acid-100556275",false,"NCT06522984","Fractional Erbium YAG Laser vs Intradermal and Systemic Tranexamic Acid","Fractional Erbium YAG Laser vs Intradermal and Systemic Tranexamic Acid in Combination With Topical Hydroquinone for Refractory Melasma","Inclusion Criteria:\n\n\\- Patients of both sexes with melasma.\n\nExclusion Criteria:\n\n* Pregnancy\n* Lactation\n* Administration of oral contraceptive pills or any phototoxic drug within 1 month prior to study\n* Patients with a history of thrombosis, abnormal bleeding profile, known hypersensitivity to TA or HQ, and endocrinal disease.","ALL","18 Years","40 Years",{"count":87,"type":88},45,"ESTIMATED","INTERVENTIONAL",[91],"NA","Melasma is a common acquired disorder of hyperpigmentaion caused by increased melanin production by melanocytes.\n\nMelasma is a name derived from the Greek word melas meaning black.It is characterized by the appearance of brownish or grayish symmetrical patches on sun-exposed skin, most commonly on the face. Compared to men, women are more likely to be affected.",[94],"Refractory Melasma","2024-07-23",{"date":97,"type":98},"2024-07-26","ACTUAL",{"date":100,"type":98},"2024-06-01",{"date":102,"type":88},"2025-06-10",{"name":5,"class":6},1]