[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643028":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":24,"responsibleParty":34,"collaborators":24,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":24,"eligibilityCriteria":44,"healthyVolunteers":40,"sex":45,"minAge":46,"maxAge":24,"enrollmentInfo":47,"targetDuration":24,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":62,"whyStopped":24,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":24},{"fullName":5,"class":6},"Bir Hospital","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Fragmentation","ACTIVE_COMPARATOR","0.8-1J, 5-10Hz",[13],"Procedure: Fragmentation",{"label":15,"type":10,"description":16,"interventionNames":17},"Dusting","0.6-0.8J, 12-15Hz",[18],"Procedure: Dusting",[20,25],{"type":21,"name":15,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Dusting employs low pulse energy (0.6-0.8 J) at higher frequency (12-15 Hz) to ablate the stone into sub-millimetre powder particles.",[15],null,{"type":21,"name":9,"description":26,"armGroupLabels":27,"otherNames":24},"Fragmentation involves delivering high pulse energy (typically 0.6-0.8 J) at low frequency (5-10 Hz) to reduce calculi into retrievable fragments of less than 4 mm.",[9],[29],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"Akash Chitrakar, MCh Urology","CONTACT","+9779849003151","dr.akashsurg@gmail.com",{"type":35,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Akash Chitrakar","Consultant Urologist","100643028","fragmentation-vs-dusting-with-fans-for-renal-stones-less-than-2cm-a-randomized-controlled-study-100643028",false,"NCT07639385","Fragmentation Vs Dusting With FANS for Renal Stones Less Than 2cm: A Randomized Controlled Study","Fragmentation Vs Dusting Using TFL With FANS for Renal Stones Less Than 2cm","Inclusion Criteria:\n\n* Age ≥18 years\n* Renal stone(s) confirmed on non-contrast CT KUB\n* Total stone less than 2cm\n* Stone amenable to flexible ureterorenoscopy (FURS)\n* FANS advanced beyond Pelvi-Ureteric Junction (PUJ)\n* Able and willing to provide written informed consent\n* Able to comply with follow-up schedule\n\nExclusion Criteria:\n\n* Active urinary tract infection (positive urine culture) at time of planned surgery\n* Anatomical anomalies precluding safe FURS (e.g., infundibular stenosis, severe calyceal diverticulum inaccessible to flexible scope)\n* Pregnancy or breastfeeding\n* Prior ipsilateral renal surgery within 3 months of enrollment\n* Concurrent ureteral stone(s) requiring simultaneous treatment\n* Renal anomalies: horseshoe kidney, ectopic kidney\n* Sheathless procedure\n* Unable to comply with follow-up or provide consent\n* Participation in another interventional trial within 30 days","ALL","18 Years",{"count":48,"type":49},86,"ESTIMATED","INTERVENTIONAL",[52],"NA","The use of FANS has changed the operative landscape of RIRS by allowing continuous active suction-assisted clearance of ablated stone material in real time. Use of fragmentation technique in FANS requires high-energy to reduce stone burden into small fragments, followed by active suction of residual fine material. Dusting with FANS, on the other hand, converts the entire stone volume into sub-millimetre particulate that is continuously suctioned away during lasing potentially offering a more streamlined workflow with potentially less energy usage, reduced mechanical stress on the ureteroscope working channel, and fewer scope withdrawals. The combination of TFL dusting with FANS-assisted real-time evacuation may produce stone-free outcomes equivalent or superior to fragmentation, while offering these additional operative efficiencies.\n\nWhether dusting using TFL with FANS is non-inferior or indeed superior to fragmentation using TFL with FANS in terms of stone-free rate at one month has not been evaluated in prospective randomised trial yet. This study aims to answer that specific question in patients with renal stone less than 2 cm.",[55,56,57,58],"Thulium Fiber Laser","Fans","Lithotripsy, Laser","Renal Stone",[15,9,60,61],"Thulium fiber laser","FANS","NOT_YET_RECRUITING","2026-06-26",{"date":65,"type":66},"2026-06-30","ACTUAL",{"date":68,"type":49},"2026-08-01",{"date":70,"type":49},"2027-08-07",{"name":5,"class":6}]