[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100527444":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":23,"locations":32,"responsibleParty":137,"collaborators":139,"id":157,"slug":158,"hasResults":159,"nctId":160,"briefTitle":161,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":159,"sex":164,"minAge":165,"maxAge":18,"enrollmentInfo":166,"targetDuration":18,"studyType":169,"phases":170,"briefSummary":172,"conditions":173,"keywords":175,"overallStatus":53,"whyStopped":18,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":192},{"fullName":5,"class":6},"University Hospital, Limoges","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"ALL participants","ALS patients will be stratified in 4 groups according to the weight loss percentage: a) no weight loss; b) \\\u003C5% of weight loss; c) 5-10% of weight loss; d) \\>10% of weight loss.\n\nIn order to identify the genomic, metabolomic, metabolic, neurofilaments, and inflammation markers associated to weight loss.",[12],"Other: Blood sample",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":18},"Blood sample","Blood sample will be taken to identify Genomic, metabolomic, metabolic, neurofilaments, and inflammation markers associated to weight loss",[9],null,[20],{"name":21,"affiliation":5,"role":22},"Philippe COURATIER, Professor","PRINCIPAL_INVESTIGATOR",[24,29],{"name":25,"role":26,"phone":27,"phoneExt":18,"email":28},"Philippe COURATIER, Pr","CONTACT","05 55 05 15 69","philippe.couratier@chu-limoges.fr",{"name":30,"role":26,"phone":18,"phoneExt":18,"email":31},"Andrea ERAZO ALEMAN, Dr","DaniellsAndrea.ERAZOALEMAN@chu-limoges.fr",[33,51,67,81,95,109,123],{"facility":34,"status":35,"city":36,"state":18,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"CHU de Lille","NOT_YET_RECRUITING","Lille","59037","France","FR",{"type":41,"coordinates":42},"Point",[43,44],3.05512,50.63391,{"lat":44,"lon":43},[47],{"name":48,"role":26,"phone":49,"phoneExt":18,"email":50},"Veronique DANEL-BRUNAUD, Medicine Doctor","+33 3 20 44 67 52","veronique.danel@chu-lille.fr",{"facility":52,"status":53,"city":54,"state":18,"zip":55,"country":38,"countryCode":39,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Limoges University Hospital","RECRUITING","Limoges","87042",{"type":41,"coordinates":57},[58,59],1.24759,45.83362,{"lat":59,"lon":58},[62,63],{"name":21,"role":26,"phone":27,"phoneExt":18,"email":28},{"name":64,"role":26,"phone":65,"phoneExt":18,"email":66},"sandra JUGE, Dr","05 55 05 64 14","sandra.juge@chu-limoges.fr",{"facility":68,"status":35,"city":69,"state":18,"zip":70,"country":38,"countryCode":39,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Hôpital de la Timone","Marseille","13005",{"type":41,"coordinates":72},[73,74],5.38107,43.29695,{"lat":74,"lon":73},[77],{"name":78,"role":26,"phone":79,"phoneExt":18,"email":80},"Shahram ATTARIAN, Professor","+33 04 91 38 65 79","sharam.attarian@ap-hm.fr",{"facility":82,"status":35,"city":83,"state":18,"zip":84,"country":38,"countryCode":39,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Hôpital Gui Chauliac","Montpellier","34295",{"type":41,"coordinates":86},[87,88],3.87635,43.61093,{"lat":88,"lon":87},[91],{"name":92,"role":26,"phone":93,"phoneExt":18,"email":94},"Elisa De La Cruz, Medicine Doctor","+33 4 67 33 76 23","e-delacruz@chu-montpellier.fr",{"facility":96,"status":35,"city":97,"state":18,"zip":98,"country":38,"countryCode":39,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"CHU de Nice","Nice","06001",{"type":41,"coordinates":100},[101,102],7.26608,43.70313,{"lat":102,"lon":101},[105],{"name":106,"role":26,"phone":107,"phoneExt":18,"email":108},"Marie-Hélène SORIANI SORIANI, Medicine Doctor","+33 4 92 03 55 04","soriani.mh@chu-nice.fr",{"facility":110,"status":35,"city":111,"state":18,"zip":112,"country":38,"countryCode":39,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"Hôpital de la Pitié Salpêtrière","Paris","75013",{"type":41,"coordinates":114},[115,116],2.3488,48.85341,{"lat":116,"lon":115},[119],{"name":120,"role":26,"phone":121,"phoneExt":18,"email":122},"Gaëlle BRUNETEAU, Professor","+33 1 42 16 24 72","gaelle.bruneteau@aphp.fr",{"facility":124,"status":35,"city":125,"state":18,"zip":126,"country":38,"countryCode":39,"cosmosGeoPoint":127,"geoPoint":131,"contacts":132},"CHU de Tours","Tours","37044",{"type":41,"coordinates":128},[129,130],0.70398,47.39484,{"lat":130,"lon":129},[133],{"name":134,"role":26,"phone":135,"phoneExt":18,"email":136},"Philippe CORCIA, Professor","+33 2 47 47 37 24","philippe.corcia@univ--tours.fr",{"type":138,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[140,142,145,147,149,151,153,155],{"name":141,"class":6},"National Research Agency, France",{"name":143,"class":144},"Centre de Recherche en biomédecine de Strasbourg INSERM UMR-S1118","UNKNOWN",{"name":146,"class":6},"Paris Brain Institute (ICM)",{"name":148,"class":144},"Institut National de la Santé et de la Recherche Médical - délégation Grand Ouest INSERM U1253",{"name":150,"class":144},"Klinik für Neurologie, Universitäts- und Rehabilitationskliniken Ulm (RKU)",{"name":152,"class":144},"Centre de Données Cliniques et de Recherche CDCR",{"name":154,"class":144},"UMR Inserm U1253-IBRain-Neurogénétique et Physiopathologie Neuronale",{"name":156,"class":144},"France Cohorte","100527444","french-german-cohort-study-to-determine-factors-associated-with-weight-loss-in-amyotrophic-lateral-sclerosis-100527444",false,"NCT06147843","French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis","FG-CoALS","Inclusion Criteria:\n\n* Incident cases included at the time of diagnosis with a definite, probable, probable laboratory-supported, or possible ALS according to El Escorial revised criteria and Gold Coast criteria for early diagnosis.\n* Incident ALS cases identified and followed-up in the participant ALS \\& Other Motor Neuron Diseases Referral Centres: seven in France and two in Germany.\n* Patients who signed the informed consent form.\n* Adults aged \\>18 years old\n\nExclusion Criteria:\n\n* Inability to understand the requirements of the protocol.\n* Cognitive inability to sign and comprehend the informed consent form.\n* Patients who will not accept Riluzole therapy during their follow-up.","ALL","18 Years",{"count":167,"type":168},1000,"ESTIMATED","INTERVENTIONAL",[171],"NA","Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Studies have shown the importance of weight loss at the time of diagnosis and during the progression of the disease. However, the pathophysiological mechanisms behind weight loss remain unknown. Identifying these mechanisms could make it possible to propose an effective therapeutic strategy against weight loss for ALS patients, which could improve their survival and quality of life. In this context, the investigators are proposing an innovative multidisciplinary project aimed at structuring a large Franco-German cohort to identify the markers associated with weight loss in ALS.\n\nParticipants will undergo high quality standard care for ALS patients. In addition, participants will be asked to respond different questionnaires and blood samples will be taken for analysis to identify biological markers.",[174],"Amyotrophic Lateral Sclerosis",[176,177,178,179,180,181,182],"Amyotrophic lateral sclerosis","Weight Loss","Genetics","Nutrition","Prognosis","Metabolomics","Inflammation","2026-06-19",{"date":185,"type":186},"2026-06-24","ACTUAL",{"date":188,"type":186},"2024-09-17",{"date":190,"type":168},"2029-09-30",{"name":5,"class":6},7]