[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642342":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":36,"locations":45,"responsibleParty":59,"collaborators":11,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":26,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":11,"enrollmentInfo":71,"targetDuration":11,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":11,"overallStatus":80,"whyStopped":11,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Beni-Suef University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"(FREMS group)","EXPERIMENTAL",null,[13],"Device: frequency rhythmic electrical modulated stimulation.",{"label":15,"type":16,"description":11,"interventionNames":17},"conservative treatment.","ACTIVE_COMPARATOR",[18],"Drug: Duloxetine - low dose",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","frequency rhythmic electrical modulated stimulation.","FREMS is characterized by sequences of biphasic electrical stimuli, with 10 consecutive sessions applied on lower limb within 10:14 days, 40 minutes for each session.",[9],[26],"FREMS",{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":11},"DRUG","Duloxetine - low dose","peripheral neuropathy conventional treatment, 30:60mg orally once\u002Fday within 10:14 days.",[15],[33],{"name":34,"affiliation":5,"role":35},"Ayman abdallah., phd","STUDY_DIRECTOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":11,"email":41},"Ibtihal Nassar, Bsc, Msc.","CONTACT","+201151678506","scholaribtihal@gmail.com",{"name":43,"role":39,"phone":44,"phoneExt":11,"email":41},"Ibtihal Nassar","01151678506",[46],{"facility":47,"status":11,"city":48,"state":11,"zip":11,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"National diabetes institute","Giza","Egypt","EG",{"type":52,"coordinates":53},"Point",[54,55],31.20861,30.00944,{"lat":55,"lon":54},[58],{"name":38,"role":39,"phone":40,"phoneExt":11,"email":41},{"type":60,"investigatorFullName":43,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","physiotherapist.","100642342","frequency-rhythmic-electrical-modulated-stimulation-effect-in-peripheral-neuropathy-patients-severity-of-cases-and-qol-100642342",false,"NCT07645482","Frequency Rhythmic Electrical Modulated Stimulation Effect in Peripheral Neuropathy Patients Severity of Cases and Qol.","Effects Of Frequency Rhythmic Electrical Modulated Stimulation (FREMS) On Blood Perfusion, Neuropathy Severity And Quality Of Life In Diabetic Patients With Peripheral Neuropathy And Lower Limb Ischemia: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* patients diagnosed with DM\n* patients age group above 40 years old.\n* patient diagnosed with peripheral neuropathy with symptoms lasts more than 3 months.\n* patients lower limb ischemia in duplex affected APSV.\n\nExclusion Criteria:\n\n* patients with implant peacemakers, defibrillator, or neurostimulator.\n* pregnancy.\n* any severe disease prevent compliance to study procedures.\n* patients with disabilities prevent their commitment to sessions.","ALL","40 Years",{"count":72,"type":73},40,"ESTIMATED","INTERVENTIONAL",[76],"NA","It's estimated that 50% of diabetic patients will have peripheral neuropathy as a complication within 3 years of the diabetes incidence \\[14\\], the goal of the study is to investigate this problem through the following objectives:\n\n1. To measure the effect of using FREMS therapy in diabetic neuropathy in interventional group on the blood perfusion, neuropathy severity and quality of life after 10 sessions compared to baseline.\n2. To measure the effect of using standard of care in diabetic neuropathy in control group on the blood perfusion, neuropathy severity and quality of life after 10 sessions compared to baseline.\n3. To compare the results between both interventional and control group.",[79],"Peripheral Neuropathy With Type 2 Diabetes","NOT_YET_RECRUITING","2026-06-09",{"date":83,"type":84},"2026-06-12","ACTUAL",{"date":86,"type":73},"2026-07",{"date":88,"type":73},"2026-08",{"name":5,"class":6},1]