[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628115":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":71,"collaborators":25,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":25,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"University of Exeter","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"GLP-1RA+EXERCISE","EXPERIMENTAL","In the resistance exercise arm participants will undergo a 20 week resistance exercise program. This will be s supervised in person session 4 times a week.",[13],"Other: Progressive Resistance Exercise Training Program",{"label":15,"type":16,"description":17,"interventionNames":18},"GLP-1RA","PLACEBO_COMPARATOR","Habitual physical activity guidelines",[19],"Other: Habitual physical activity guidelines",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Progressive Resistance Exercise Training Program","Participants in the GLP-1 + Exc group will participate in a 20 Week Progressive Resistance Exercise Training Program. This will be a low impact training program created by PVolve LLC. The plan will increase in session frequency and volume reaching 4 sessions per week at week 4 up until week 20 and will comprise of mostly banded, weighted or bodyweight exercises with small high intensity interval sessions after some of the sessions.\n\nParticipants will attend the exercise classes on site at the St Luke's campus which will be delivered by PVolve instructors via video demonstration. Classes will be supervised by a member of the research team at all times.",[9],null,{"type":6,"name":17,"description":27,"armGroupLabels":28,"otherNames":25},"Control group consisting of continuing habitual physical activity guidelines for 20 weeks",[15],[30],{"name":31,"affiliation":5,"role":32},"Francis B Stephens, PhD","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Thomas P J Kennedy, MSc","CONTACT","+44 7470074405","tk509@exeter.ac.uk",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},"Sarah K Graham, MSc","+44 7789552977","sg1034@exeter.ac.uk",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Nutritional Physiology Research Unit","RECRUITING","Exeter","Devon","EX2 4TH","United Kingdom","UK",{"type":53,"coordinates":54},"Point",[55,56],-3.52751,50.7236,{"lat":56,"lon":55},[59,63,67,68,70],{"name":60,"role":36,"phone":61,"phoneExt":25,"email":62},"Professor Francis Stephens","01392 6612157","F.B.Stephens@exeter.ac.uk",{"name":64,"role":36,"phone":65,"phoneExt":25,"email":66},"Professor Benjamin Wall","01392 72 4774","B.T.Wall@exeter.ac.uk",{"name":60,"role":32,"phone":25,"phoneExt":25,"email":25},{"name":35,"role":69,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"name":40,"role":69,"phone":25,"phoneExt":25,"email":25},{"type":32,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Francis Stephens","Professor","100628115","function-and-lean-mass-preservation-with-resistance-exercise-during-a-glp-1ra-treatment-100628115",false,"NCT07457437","Function and Lean Mass Preservation With Resistance Exercise During a GLP-1RA Treatment","Effect of a Progressive Resistance Exercise Program on Muscle Mass and Physical Function During a Tirzepatide Induced Weight Loss in Overweight and Obese Females: a Randomised Parallel Group Study","FLEX","Inclusion Criteria:\n\n* 25-50 years old\n* BMI ≥27 kg\u002Fm2 with one obesity related co-morbidity or a BMI between ≥30 and 35 kg\u002Fm2\n* Female\n\nExclusion Criteria:\n\n* Previous GLP-1RA use\n* Diabetes (Type 1 and 2)\n* Contraindicative health condition to GLP-1\u002FGIP\n* Fail clinically administered health screening form for tirzepatide prescription\n* Pregnant or wanting to become pregnant in the next 6 months\n* Has or has previously had an eating disorder\n* Inability to perform exercise program and exercise tests\n* Advised not to exercise by their general practitioner or medical professional\n* Current or recent injury within the last 6 months that may affect the ability to carry out resistance exercise\n* Has consistently resistance trained previously (\\>10 sessions per year)\n* Currently taking medication or supplements that have been shown to impact muscle function and muscle mass in the last 6 months\n* Current or recent, ≤6 months, smoker\n* Currently on HRT",true,"FEMALE","25 Years","50 Years",{"count":87,"type":88},60,"ESTIMATED","INTERVENTIONAL",[91],"NA","This study aims to investigate the effect that a structured, progressive resistance exercise program may have on maintaining the muscle mass and physical function of overweight\u002F obese females whilst they experience a tirzepatide (GLP-1\u002FGIP receptor agonist) induced weight loss.\n\nOverweight and obese females aged 25-50 will be recruited for the study, they will require a BMI of \\>30 or \\>27 with one obesity related comorbidity (excluding diabetes). They will be screened, prescribed tirzepatide and then randomly assigned to either the intervention (GLP-1\u002FGIP + Exercise) or the control group (GLP-1\u002FGIP). Groups will then be split into pre and peri menopausal groups to provide a further exploratory pathway looking analysing if the menopause transition may have any effect on our outcome variables. This was proposed as in the UK females are more likely to begin GLP-1RA treatment.\n\nBoth groups will be given an industry standard treatment of tirzepatide over 20 weeks starting at a dose of 2.5mg\u002Fweek and following the dose titration process of +2.5mg\u002Fweek every four weeks outlined by its manufacturers. The Exercise Group (GLP-1 +EXC) will be given the same tirzepatide prescription alongside following a progressive resistance exercise program. The exercise program will follow a similar structure to previous work in which participants will complete a propriety 20-wk whole body, low impact resistance exercise training program four times a week. The exercise sessions will be up to an hour and will be instructor lead by video and supervised by a member of the research team at The University of Exeter.",[94,95,96],"Muscle Mass and Strength","Obesity & Overweight","Physical Function",[98,99,100,101,102],"Maintaining muscle mass on GLP-1RA, physical function on GLP-1RA, tirzepatide, Mounjaro,","Body composition changes during GLP-1\u002FGIP RA weight loss","Resistance exercise and Perimenopause","Lean mass and Tirzepatide","Health outcomes and obesity","2026-03-23",{"date":105,"type":106},"2026-03-27","ACTUAL",{"date":108,"type":88},"2026-04-01",{"date":110,"type":88},"2027-12-01",{"name":5,"class":6},1]