[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584055":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":21,"locations":30,"responsibleParty":86,"collaborators":10,"id":88,"slug":89,"hasResults":90,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":90,"sex":96,"minAge":10,"maxAge":10,"enrollmentInfo":97,"targetDuration":10,"studyType":100,"phases":10,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":55,"whyStopped":10,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"IRCCS Policlinico S. Donato","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Normal cardiac parameters and normal T1",null,"AFD patients with normal cardiac parameters and normal T1.",{"label":13,"type":10,"description":14,"interventionNames":10},"Normal cardiac parameters and reduced T1","AFD patients with no LVH and myocardial reduced T1 .",{"label":16,"type":10,"description":17,"interventionNames":10},"LVH without LGE","Patients with LVH without LGE.",{"label":19,"type":10,"description":20,"interventionNames":10},"Advanced cardiomyopathy with LVH and LGE","AFD patients with advanced cardiomyopathy with LVH and LGE.",[22,27],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Massimo Piepoli, MD, PhD","CONTACT","+39 0252774942","massimo.piepoli@grupposandonato.it",{"name":28,"role":24,"phone":25,"phoneExt":10,"email":29},"Gianluigi Guida, MD","gianluigi.guida@grupposandonato.it",[31,44,53,68,77],{"facility":32,"status":33,"city":34,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":10},"Spedali Civili Hospital","ACTIVE_NOT_RECRUITING","Brescia","25123","Italy","IT",{"type":39,"coordinates":40},"Point",[41,42],10.21472,45.53558,{"lat":42,"lon":41},{"facility":45,"status":33,"city":46,"state":46,"zip":47,"country":36,"countryCode":37,"cosmosGeoPoint":48,"geoPoint":52,"contacts":10},"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","Milan","20122",{"type":39,"coordinates":49},[50,51],9.18951,45.46427,{"lat":51,"lon":50},{"facility":54,"status":55,"city":56,"state":46,"zip":57,"country":36,"countryCode":37,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"IRCCS Policlinico San Donato","RECRUITING","San Donato Milanese","20097",{"type":39,"coordinates":59},[60,61],9.26838,45.41047,{"lat":61,"lon":60},[64,65],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},{"name":66,"role":67,"phone":10,"phoneExt":10,"email":10},"Massimo Piepoli","PRINCIPAL_INVESTIGATOR",{"facility":69,"status":33,"city":70,"state":70,"zip":71,"country":36,"countryCode":37,"cosmosGeoPoint":72,"geoPoint":76,"contacts":10},"Fondazione IRCCS San Gerardo dei Tintori","Monza","20900",{"type":39,"coordinates":73},[74,75],9.27246,45.58005,{"lat":75,"lon":74},{"facility":78,"status":33,"city":79,"state":79,"zip":80,"country":36,"countryCode":37,"cosmosGeoPoint":81,"geoPoint":85,"contacts":10},"Regina Margherita Hospital","Turin","10124",{"type":39,"coordinates":82},[83,84],7.68682,45.07049,{"lat":84,"lon":83},{"type":67,"investigatorFullName":66,"investigatorTitle":87,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"MD, PhD","100584055","functional-capacity-in-anderson-fabry-disease-patients-100584055",false,"NCT06884358","Functional Capacity in Anderson-Fabry Disease Patients","FunctiOnal caPaciTy Evaluation Using cardIopulMonary Testing and Stress echocArdiography in Anderson-Fabry Disease Patients: OPTIMA-FD Study","OPTIMA-FD","Inclusion Criteria:\n\n* Patients with a genetic diagnosis of AFD, according to current guidelines;\n* Informed written consent with the understanding that consent may be withdrawn by the patient at any time without prejudice to future medical care (for patients age \\\u003C18 years old, written consent from a caregiver is mandatory).\n\nExclusion Criteria:\n\n* eGFR \\\u003C30 ml\u002Fmin and other contraindications for CMR (relative controindication: patients with implantable device);\n* Musculoskeletal limitation for exercise test on the cyclo ergometer;\n* Pregnant or breastfeeding women;\n* Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with a full comprehension of the written consent form.","ALL",{"count":98,"type":99},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to observe the relation between excercise parameters - assessed by CPET - and rest\u002Fstress hemodynamic parameters - assessed by echocardiogram and CMR - in patients with a genetic diagnosis of Anderson-Fabry Disease.\n\nParticipants will undergo:\n\n* baseline evaluation: clinical evaluation, disease staging with FASTEX and MSSI, KCCQ for quality of life assessment, resting 12-leads ECG, 6MWT, CPET-ESE and contrast-enhanced CMR;\n* before 36 months from baseline: resting 12-leads ECG, 2D rest and stress echocardiogram, CPET-ESE, contrast-enhanced CMR, disease staging with FASTEX and MSSI and KCCQ for quality of life assessment;\n* up to 7 years from baseline: clinical follow-up.",[103],"Anderson-Fabry Disease",[103,105,106,107],"Cardiac Involvement","CMR","CPET","2026-07-01",{"date":110,"type":111},"2026-07-02","ACTUAL",{"date":113,"type":111},"2024-11-13",{"date":115,"type":99},"2032-01",{"name":5,"class":6},5]