[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100414454":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":31,"responsibleParty":77,"collaborators":80,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":94,"sex":100,"minAge":101,"maxAge":18,"enrollmentInfo":102,"targetDuration":18,"studyType":105,"phases":106,"briefSummary":108,"conditions":109,"keywords":115,"overallStatus":34,"whyStopped":18,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},{"fullName":5,"class":6},"University of Aarhus","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"SPECT functional avoidance treatment","EXPERIMENTAL","SPECT-based radiation therapy given taken functional distribution in the lung into account, that avoids highly functional lung volumes sparing them from radiation.",[13],"Diagnostic Test: Single-photon-emission CT scan",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard treatment","NO_INTERVENTION","CT-based radiation therapy given over 5- 6.5 weeks.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DIAGNOSTIC_TEST","Single-photon-emission CT scan","SPECT\u002FCT scan is an established functional modality used in the diagnosis and monitoring of lung disease. SPECT\u002FCT scan images pulmonary circulation, where perfused areas equate with normal functional lung",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Katherina Farr, MD PhD FRACP","CONTACT","+61 412695410","Katherina.Farr@health.nsw.gov.au",[32,54],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Sydney West Radiation Oncology Network Westmead and Blacktown Hospitals","RECRUITING","Sydney","New South Wales","2145","Australia","AU",{"type":41,"coordinates":42},"Point",[43,44],151.20732,-33.86785,{"lat":44,"lon":43},[47,51],{"name":48,"role":28,"phone":49,"phoneExt":18,"email":50},"Eric Hau, MBBS PhD FRANZCR","+61 432207880","Eric.Hau@health.nsw.gov.au",{"name":52,"role":53,"phone":18,"phoneExt":18,"email":18},"Eric Hau, MBBS PhD","SUB_INVESTIGATOR",{"facility":55,"status":34,"city":56,"state":18,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Department of Oncology, Aarhus University Hospital","Aarhus","DK-8000","Denmark","DK",{"type":41,"coordinates":61},[62,63],10.21076,56.15674,{"lat":63,"lon":62},[66,70,73,76],{"name":67,"role":28,"phone":68,"phoneExt":18,"email":69},"Azza Khalil, MD, PhD","004578465000","azza.khalil@auh.rm.dk",{"name":71,"role":28,"phone":68,"phoneExt":18,"email":72},"Line Sparvath","linspa@rm.dk",{"name":74,"role":75,"phone":18,"phoneExt":18,"email":18},"Katherina Farr, MD, PhD","PRINCIPAL_INVESTIGATOR",{"name":67,"role":53,"phone":18,"phoneExt":18,"email":18},{"type":75,"investigatorFullName":74,"investigatorTitle":78,"investigatorAffiliation":79,"oldNameTitle":18,"oldOrganization":18},"Specialist in Clinical Oncology","Aarhus University Hospital",[81,84,85,88,90],{"name":82,"class":83},"Westmead and Blacktown Hospital, Sydney West Radiation Oncology Network, Sydney, Australia","UNKNOWN",{"name":79,"class":6},{"name":86,"class":87},"South Eastern Sydney Local Health District","OTHER_GOV",{"name":89,"class":6},"The University of New South Wales",{"name":91,"class":83},"Northern NSW Local Health District, NSW Australia","100414454","functional-lung-avoidance-spect-guided-radiation-therapy-of-lung-cancer-100414454",false,"NCT04676828","Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer","Functional Lung Avoidance SPECT-guided (ASPECT) Radiation Therapy for Lung Cancer Patients: Phase II Randomised Clinical Trial","ASPECT","Inclusion Criteria:\n\n* histologically verified lung cancer (small-cell and non-small cell lung cancer)\n* referred for radiotherapy with curative intent\n* radiation dose of 60-66 Gy given in 2-Gy fractions, other dose levels and fractionation schedules accepted, as per site standard\n* concurrent chemotherapy is accepted\n* patients with oligometastatic disease are allowed, where metastasis have been ablated with surgery or radiotherapy\n* receiving (chemo)-radiotherapy to the thoracic disease with curative intent\n* adults over 18, that have given oral and written informed consent before patient registration.\n\nExclusion Criteria:\n\n* concurrent immunotherapy\n* previous radiotherapy to the thorax\n* other uncontrolled malignancies; any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol","ALL","18 Years",{"count":103,"type":104},90,"ESTIMATED","INTERVENTIONAL",[107],"NA","Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)\u002FCT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy. Functional avoidance implies a dose plan that takes functional distribution in the lung into account, and avoids highly functional lung volumes sparing them from radiation.",[110,111,112,113,114],"Lung Cancer","Radiation-Induced Disorder","Radiation Pneumonitis","Pulmonary Disease","Lung Function Decreased",[116,117,118],"radiation-induced lung toxicity","functional avoidance methodology","radiation therapy of lung cancer","2026-02-22",{"date":121,"type":122},"2026-02-24","ACTUAL",{"date":124,"type":122},"2021-12-01",{"date":126,"type":104},"2028-12-01",{"name":5,"class":6},2]