[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100450604":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":25,"locations":32,"responsibleParty":52,"collaborators":24,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":24,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":24,"overallStatus":35,"whyStopped":24,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"CHU de Reims","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"non-OSAS patients","ACTIVE_COMPARATOR","Patients without OSAS (Apnea-Hypopnea Index (AHI) \\\u003C 15\u002Fh and absence of excessive daytime sleepiness with Epworth score \\\u003C11)",[13],"Diagnostic Test: functional magnetic resonance imaging",{"label":15,"type":16,"description":17,"interventionNames":18},"OSAS patients","EXPERIMENTAL","Patients with severe OSAS with an Apnea-Hypopnea Index (AHI) \\> 30\u002Fh",[13],[20],{"type":21,"name":22,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","functional magnetic resonance imaging",[15,9],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Claire Launois","CONTACT","3 26 78 83 70","0033","claunois@chu-reims.fr",[33],{"facility":34,"status":35,"city":36,"state":24,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Chu Reims","RECRUITING","Reims","51092","France","FR",{"type":41,"coordinates":42},"Point",[43,44],4.02853,49.26526,{"lat":44,"lon":43},[47],{"name":48,"role":28,"phone":49,"phoneExt":50,"email":51},"Damien JOLLY","326788472","33","djolly@chu-reims.fr",{"type":53,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100450604","functional-magnetic-resonance-imaging-in-patients-with-obstructive-sleep-apnea-syndrome-100450604",false,"NCT05147649","Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome","Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome, With and Without CPAP, During Wakefulness - Impact on Cognitive Functions","IRM SAOS","Inclusion criteria :\n\n1. OSAS patients\n\n   * severe OSAS with an Apnea-Hypopnea Index (AHI) \\> 30\u002Fh\n   * without CPAP treatment\n2. Non-OSAS patients\n\n   * absence of OSAS (AHI \\\u003C 15\u002Fh and absence of excessive daytime sleepiness with Epworth score \\\u003C11)\n\nNon-inclusion criteria :\n\n* \\\u003C 18 years old\n* \\>75 years old\n* left-handed\n* BMI\\> 40 kg\u002Fm²\n* another sleep disorder\n* central component of sleep apnea syndrome (central apnea index\\> 5 \u002F h)\n* current or past neurological pathology\n* respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia)\n* MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.)\n* taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.),\n* uncorrected sensory impairment (vision or hearing)\n* protected by law.\n\nExclusion criteria :\n\n* pregnant woman according to the positive beta-hCG test result\n* left-handed following the laterality questionnaire\n* MINI results showing:\n\n  * a current mood episode\n  * a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco)\n  * an eating disorder\n  * a diagnosis of bipolar disorder, current or past schizophrenia",true,"ALL","18 Years","75 Years",{"count":67,"type":68},70,"ESTIMATED","INTERVENTIONAL",[71],"NA","The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.",[74],"Obstructive Sleep Apnea Syndrome","2025-11-28",{"date":77,"type":78},"2025-12-02","ACTUAL",{"date":80,"type":78},"2023-03-02",{"date":82,"type":68},"2027-07-02",{"name":5,"class":6},1]