[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618928":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":45,"locations":51,"responsibleParty":70,"collaborators":31,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":31,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":31,"maxAge":31,"enrollmentInfo":82,"targetDuration":31,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":54,"whyStopped":31,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"University of Health Sciences Lahore","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"pleural lavage group","EXPERIMENTAL","participants of this group are diagnosed as having fungal empyema on investigations of pleural fluid before any kind of surgical intervention is carried out.",[13],"Procedure: pleural lavage followed by surgery",{"label":15,"type":16,"description":17,"interventionNames":18},"Surgical group","ACTIVE_COMPARATOR","Participants of this group are misdiagnosed as having bacterial empyema before surgery, but diagnosed as having fungal empyema intra-operatively or after surgery on post-operative culture results.",[19],"Procedure: Decortication",{"label":21,"type":16,"description":22,"interventionNames":23},"Non-surgical group","participants of this group are diagnosed as having fungal empyema and they are unfit for any kind of surgical intervention and are only managed with pleural lavage with anti-fungal drugs.",[24],"Other: Conservative Arm",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","pleural lavage followed by surgery","participants of this group are managed with pleural lavage with anti-fungals and than decortication is performed.",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Decortication","patient underwent direct surgery for fungal empyema",[15],{"type":6,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Conservative Arm","patients are only managed with pleural lavage",[21],[41],{"name":42,"affiliation":43,"role":44},"Muhammad Shoaib Nabi, FCPS","Saglik Bilimleri Universitesi","STUDY_CHAIR",[46],{"name":47,"role":48,"phone":49,"phoneExt":31,"email":50},"Zeeshan Sarwar, MBBS","CONTACT","+923214347410","zeeshan.sarwar195@gmail.com",[52],{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Services Hospital Lahore","RECRUITING","Lahore","Punjab Province","54000","Pakistan","PK",{"type":61,"coordinates":62},"Point",[63,64],74.35071,31.558,{"lat":64,"lon":63},[67],{"name":42,"role":48,"phone":68,"phoneExt":31,"email":69},"+923009403511","one111@gmail.com",{"type":71,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Zeeshan Sarwar","Dr","100618928","fungal-empyema-thoracis-100618928",false,"NCT07337993","Fungal Empyema Thoracis","Efficacy of Pleural Lavage With Antifungals in the Management of Fungal Empyema Thoracis: A Prospective Cohort Study","Inclusion Criteria:\n\n* All age patients with confirmed fungal empyema thoracis.\n* Patients with adequate pleural drainage through an intercostal chest tube.\n* Patients receiving systemic antifungal therapy.\n* Patients either:\n\n  1. scheduled for surgical decortication but undergoing lavage as a preoperative adjunct, or\n  2. considered unfit for surgery and managed conservatively.\n\nExclusion Criteria:\n\n* Bacterial empyema without fungal growth.\n* Known hypersensitivity to anti-fungals.\n* Severe hepatic impairment (Child-Pugh class C) contraindicating voriconazole.\n* Pregnancy or lactation.\n* Refusal to participate.","ALL",{"count":83,"type":84},50,"ESTIMATED","INTERVENTIONAL",[87],"NA","Background:\n\nFungal empyema thoracis is a rare but life-threatening pleural infection caused by fungal organisms such as Aspergillus and Candida species. It typically occurs in immunocompromised or debilitated patients and carries a high mortality rate. Conventional management involves systemic antifungal therapy and surgical decortication; however, many patients are unfit for surgery due to poor clinical status or multiple comorbidities. The use of local intrapleural antifungal therapy remains poorly studied.\n\nObjective:\n\nThis study aims to evaluate the efficacy and safety of pleural lavage with voriconazole in patients with fungal empyema thoracis, both as a pre-surgical adjunct and as a palliative measure for patients who cannot undergo surgery.\n\nMethods:\n\nA prospective cohort study will be conducted at the Department of Thoracic Surgery, Services Hospital, Lahore. Patients diagnosed with fungal empyema confirmed by pleural fluid culture or cytology will be included. Through an indwelling chest tube, voriconazole (200 mg in 100 mL normal saline) will be instilled into the pleural cavity once daily for three consecutive days. Patients will be assessed for improvement in clinical symptoms, radiological clearance, reduction in fungal load, and the need for surgical intervention. Data will be statistically analyzed to determine treatment response and safety outcomes.\n\nConclusion:\n\nPleural lavage with voriconazole offers a promising, minimally invasive approach for managing fungal empyema thoracis. If proven effective, this method could serve as a valuable addition to current antifungal strategies, improving outcomes for critically ill patients who are not candidates for surgery.",[90,91,92],"Pyothorax","Fungal Infection Lungs","Pleural Empyema",[94,95,96],"Fungal Pyothorax","pleural lavage","anti-fungals","2026-01-03",{"date":99,"type":100},"2026-01-13","ACTUAL",{"date":102,"type":100},"2025-07-01",{"date":104,"type":84},"2027-03-31",{"name":5,"class":6},1]