[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621004":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":55,"collaborators":26,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":26,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":82,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Tel Aviv University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Gaze contingent negative reinforcement","ACTIVE_COMPARATOR","participants will receive gaze-contingent negative reinforcement according to their viewing patterns",[13],"Behavioral: Aversive white noise",{"label":15,"type":16,"description":17,"interventionNames":18},"Gaze contingent positive reinforcement","PLACEBO_COMPARATOR","participants will receive gaze-contingent positive reinforcement according to their viewing patterns",[19],"Behavioral: Music reward",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Aversive white noise","Participants will receveve gaze-contingent negative-reinforcement feedback according to their viewing patterns, such that when gazing at the target stimuli (i.e., happy faces) the noise will stop.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Music reward","Participants will receive gaze-contingent music-reward according to their viewing patterns, such that when gazing at the target stimuli (i.e., happy faces) the music will play.",[15],[32],{"name":33,"affiliation":5,"role":34},"Amit Lazarov, PhD","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Shani Lavi, M.A.","CONTACT","+972 50 2656664","shanilavi@mail.tau.ac.il",[42],{"facility":5,"status":26,"city":43,"state":26,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Tel Aviv","6997801","Israel","IL",{"type":48,"coordinates":49},"Point",[50,51],34.78057,32.08088,{"lat":51,"lon":50},[54],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},{"type":34,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Amit Lazarov","Professor of Psychology, School of Psychological Sciences","100621004","gaze-contingent-attentional-reinforcement-in-major-depressive-disorder-100621004",false,"NCT07364981","Gaze Contingent Attentional Reinforcement in Major Depressive Disorder","Gaze Contingent Attentional Reinforcement Treatment of MDD","Inclusion Criteria:\n\n* Primary diagnosis of MDD\n* MADRS\\>=7\n* Normal or corrected-t-normal vision\n\nExclusion Criteria:\n\n* Present or past psychosis, manic or hypomanic episode, PTSD\n* High suicidal ideation or behavior\n* Severe alcohol or cannabis use disorder, and\u002For any severity of other substance use disorder (exepct nicotine use)\n* Pharmacological treatment if not stabilized for at least three months or concurrent psychotherapy\n* Current unstable or untreated medical illness\n* Current or past organic mental disorder, seizure or brain injury\n* Eye-tracking calibration difficulties\n* Post-ECT treatment","ALL","18 Years","65 Years",{"count":69,"type":70},60,"ESTIMATED","INTERVENTIONAL",[73],"NA","The main objective of this randomized controlled trial is to evaluate whether a gaze-contingent feedback task using negative reinforcement can serve as an effective attention-modification procedure and contribute to the treatment of Major Depressive Disorder (MDD).",[76],"Major Depressive Disorder (MDD)",[78,79,80,81],"MDD","attention allocation","positive reinforcement","negative reinforcement","NOT_YET_RECRUITING","2026-01-18",{"date":85,"type":86},"2026-01-23","ACTUAL",{"date":88,"type":70},"2026-01-01",{"date":90,"type":70},"2030-01-01",{"name":5,"class":6},1]