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Devices will be worn continuously and changed every 24 hours. Treatment will be continued for a maximum of 30 days or until patient recovers mobility, or is discharged into the community, or meet other defined criteria, whichever comes earlier.",[13],"Device: geko™ device",{"label":15,"type":16,"description":17,"interventionNames":18},"Intermittent Pneumatic Compression (IPC)","NO_INTERVENTION","Control treatment will be IPC using NHS approved devices as used for standard clinical care. They will be applied to both legs as soon as possible after randomisation. They will not be changed unless damaged or soiled. Treatment will be continued for a maximum of 30 days or until patient recovers mobility, or is discharged into the community, or meet other defined criteria, whichever comes earlier.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","geko™ device","Neuromuscular electrical stimulation of the peroneal nerve",[9],[26,27],"geko","NMES",[29],{"name":30,"affiliation":31,"role":32},"Christine Roffe, MD FRCP FESO","Keele University, University Hospitals of North Midlands NHS Trust","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":18,"email":38},"Kieron Day, DPhil","CONTACT","+44 (0) 7921 106253","Kieron.Day@firstkindmedical.com",{"name":40,"role":36,"phone":41,"phoneExt":18,"email":42},"Wing To, PhD","+44 (0) 7827 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4297",{"name":317,"role":32,"phone":18,"phoneExt":18,"email":18},"Khalid Rashed, Dr",{"type":319,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[321,324,327,329,331],{"name":322,"class":323},"National Institute for Health Research, United Kingdom","OTHER_GOV",{"name":325,"class":326},"Keele University","OTHER",{"name":328,"class":326},"University Hospitals of North Midlands NHS Trust",{"name":330,"class":326},"University of California",{"name":332,"class":326},"Bournemouth University","100475898","geko-venous-thromboembolism-prevention-study-100475898",false,"NCT05476913","GEKO Venous Thromboembolism Prevention Study","A Randomised Controlled Trial of the Effectiveness of Intermittent Surface Neuromuscular Stimulation Using the Geko™ Device Compared With Intermittent Pneumatic Compression to Prevent Venous Thromboembolism in Immobile Acute Stroke Patients","Inclusion Criteria:\n\n1. Age 18 years or older\n2. Clinical diagnosis of acute stroke (WHO criteria)\n3. Within 36 hours of symptom onset\n4. Not able to get up from a chair\u002Fout of bed and walk to the toilet without the help of another person\n\nExclusion Criteria:\n\n1. Inability to gain consent from the patient, or a declaration from a Personal Consultee or Nominated Consultee\n2. Unwitnessed onset with a long lie on the floor before admission\n3. Clinically apparent deep vein thrombosis at screening\n4. Patient is expected to require palliative care within 14 days\n5. Patient does not live in the local catchment area and is expected to be transferred to their local hospital for on-going care.\n6. Patient has recently been involved in or is currently involved in a clinical trial for either a medical device or medicinal product, within the past 3 months, with the exception: if co-enrolment is not considered to impact adverse events or outcomes in the opinion of the Chief Investigator. (A live document containing a list of approved studies will be included in a reference document made available to all study sites and available upon request)\n7. Contraindications for the use of the geko™ device:\n\n   * Allergy to hydrogel constituents\n8. Contraindications to IPC:\n\n   * Severe peripheral vascular disease\n   * Large leg ulcers requiring extensive bandaging (small ulcers or skin breaks with flat coverings are not an exclusion)\n   * Severe oedema\n   * Leg deformities making appropriate fitting impossible\n9. Uncontrolled congestive cardiac failure\n10. Pregnancy\n11. Single or double leg amputations","ALL","18 Years",{"count":343,"type":344},1200,"ESTIMATED","INTERVENTIONAL",[347],"NA","This multicentre, randomised geko™ venous thromboembolism (VTE) prevention study will prospectively collect clinical data on VTE occurrences in immobile patients after stroke, who will be randomised, on a 1:1 allocation, to receive either standard of care (Intermittent Pneumatic Compression) or geko™ neuromuscular electrostimulation device. The aim is to assess the prevention of VTE during a follow-up period of 90 days (three months) post-randomisation.",[350,351,352,353],"Stroke, Acute","Venous Thromboembolism","Deep Vein Thrombosis","Pulmonary Embolism",[26,355,350,351,353,356],"intermittent pneumatic compression","DVT prophylaxis","2025-02-27",{"date":359,"type":360},"2025-03-04","ACTUAL",{"date":362,"type":360},"2023-07-06",{"date":364,"type":344},"2025-06-30",{"name":5,"class":6},18]