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University","Columbus","43210",{"type":45,"coordinates":697},[698,699],-82.99879,39.96118,{"lat":699,"lon":698},[702,705],{"name":703,"role":32,"phone":10,"phoneExt":10,"email":704},"Hazel Antao","Hazel.Antao@osumc.edu",{"name":706,"role":28,"phone":10,"phoneExt":10,"email":10},"Asrar Alahmadi",{"facility":708,"status":38,"city":694,"state":662,"zip":709,"country":42,"countryCode":43,"cosmosGeoPoint":710,"geoPoint":712,"contacts":713},"OhioHealth Reseach Institute","43214",{"type":45,"coordinates":711},[698,699],{"lat":699,"lon":698},[714,717],{"name":715,"role":32,"phone":10,"phoneExt":10,"email":716},"Kevin Miller","Kevin.Miller@ohiohealth.com",{"name":718,"role":28,"phone":10,"phoneExt":10,"email":10},"Arvinder Bhinder, MD",{"facility":720,"status":38,"city":721,"state":662,"zip":722,"country":42,"countryCode":43,"cosmosGeoPoint":723,"geoPoint":727,"contacts":728},"Taylor Cancer Research Center","Maumee","43537",{"type":45,"coordinates":724},[725,726],-83.65382,41.56283,{"lat":726,"lon":725},[729,732],{"name":730,"role":32,"phone":10,"phoneExt":10,"email":731},"Jennifer Martinez","jmartinez@toledoclinic.com",{"name":733,"role":28,"phone":10,"phoneExt":10,"email":10},"John Nemunaitis, MD",{"facility":735,"status":38,"city":736,"state":737,"zip":738,"country":42,"countryCode":43,"cosmosGeoPoint":739,"geoPoint":743,"contacts":744},"Hightower Clinical","Oklahoma City","Oklahoma","73102",{"type":45,"coordinates":740},[741,742],-97.51643,35.46756,{"lat":742,"lon":741},[745,748],{"name":746,"role":32,"phone":10,"phoneExt":10,"email":747},"Caitlin Merrick","caitlin@hightowerclinical.com",{"name":749,"role":28,"phone":10,"phoneExt":10,"email":10},"Thy Nguyen, MD",{"facility":751,"status":38,"city":736,"state":737,"zip":752,"country":42,"countryCode":43,"cosmosGeoPoint":753,"geoPoint":755,"contacts":756},"Mercy Clinic Oncology and Hematology - Coletta","73120",{"type":45,"coordinates":754},[741,742],{"lat":742,"lon":741},[757,760],{"name":758,"role":32,"phone":10,"phoneExt":10,"email":759},"Marian Nolen","Marian.Nolen@mercy.net",{"name":761,"role":28,"phone":10,"phoneExt":10,"email":10},"Carla Kurkjian, MD",{"facility":763,"status":38,"city":764,"state":737,"zip":765,"country":42,"countryCode":43,"cosmosGeoPoint":766,"geoPoint":770,"contacts":771},"Oklahoma Cancer Specialists and Research Institute","Tulsa","74146",{"type":45,"coordinates":767},[768,769],-95.99277,36.15398,{"lat":769,"lon":768},[772,776],{"name":773,"role":32,"phone":774,"phoneExt":10,"email":775},"Stephanie Sandoval","918-505-3200","stephanie.sandoval@ocsri.org",{"name":777,"role":28,"phone":10,"phoneExt":10,"email":10},"Paul Zito, MD",{"facility":779,"status":38,"city":780,"state":781,"zip":782,"country":42,"countryCode":43,"cosmosGeoPoint":783,"geoPoint":787,"contacts":788},"Oregon Oncology Specialists","Salem","Oregon","97301",{"type":45,"coordinates":784},[785,786],-123.0351,44.9429,{"lat":786,"lon":785},[789,792],{"name":790,"role":32,"phone":10,"phoneExt":10,"email":791},"Cheryl LaBronte","clabronte@orcancer.com",{"name":793,"role":28,"phone":10,"phoneExt":10,"email":10},"Janelle Meyer, MD",{"facility":795,"status":38,"city":796,"state":797,"zip":798,"country":42,"countryCode":43,"cosmosGeoPoint":799,"geoPoint":803,"contacts":804},"Cancer Care Associates of York","York","Pennsylvania","17403",{"type":45,"coordinates":800},[801,802],-76.72774,39.9626,{"lat":802,"lon":801},[805,810],{"name":806,"role":32,"phone":807,"phoneExt":808,"email":809},"Jennifer Stough","717-741-9229","149","jstough@cancercareyork.com",{"name":811,"role":28,"phone":10,"phoneExt":10,"email":10},"Chanh Hyunh, MD",{"facility":813,"status":38,"city":814,"state":815,"zip":816,"country":42,"countryCode":43,"cosmosGeoPoint":817,"geoPoint":821,"contacts":822},"The Medical University of South Carolina","Charleston","South Carolina","29425",{"type":45,"coordinates":818},[819,820],-79.93275,32.77632,{"lat":820,"lon":819},[823,826],{"name":824,"role":32,"phone":10,"phoneExt":10,"email":825},"Tyson Kelsey","tysonke@musc.edu",{"name":827,"role":28,"phone":10,"phoneExt":10,"email":10},"Christopher Gilbert, MD",{"facility":829,"status":38,"city":830,"state":831,"zip":832,"country":42,"countryCode":43,"cosmosGeoPoint":833,"geoPoint":837,"contacts":838},"Baptist Cancer Center","Memphis","Tennessee","38120",{"type":45,"coordinates":834},[835,836],-90.04898,35.14953,{"lat":836,"lon":835},[839,843],{"name":840,"role":32,"phone":841,"phoneExt":10,"email":842},"Angela Gates","901-317-0644","angela.gates@tempus.com",{"name":844,"role":28,"phone":10,"phoneExt":10,"email":10},"Raymond Osarogiagbon, MD",{"facility":846,"status":38,"city":847,"state":848,"zip":849,"country":42,"countryCode":43,"cosmosGeoPoint":850,"geoPoint":854,"contacts":855},"University of Virginia","Charlottesville","Virginia","22908",{"type":45,"coordinates":851},[852,853],-78.47668,38.02931,{"lat":853,"lon":852},[856],{"name":857,"role":32,"phone":10,"phoneExt":10,"email":858},"Ryan Gentzler Principal Investigator","rg2uc@virginia.edu",{"facility":860,"status":38,"city":861,"state":862,"zip":863,"country":42,"countryCode":43,"cosmosGeoPoint":864,"geoPoint":868,"contacts":869},"PeaceHealth St. Joseph Medical Center-Bellingham","Bellingham","Washington","98225",{"type":45,"coordinates":865},[866,867],-122.48822,48.75955,{"lat":867,"lon":866},[870,873],{"name":871,"role":32,"phone":10,"phoneExt":10,"email":872},"Rebecca Crompton","rcrompton@peacehealth.org",{"name":874,"role":28,"phone":10,"phoneExt":10,"email":10},"Mervat Saleh, MD",{"facility":876,"status":38,"city":877,"state":862,"zip":878,"country":42,"countryCode":43,"cosmosGeoPoint":879,"geoPoint":883,"contacts":884},"Cancer Care Northwest","Spokane Valley","99216",{"type":45,"coordinates":880},[881,882],-117.23937,47.67323,{"lat":882,"lon":881},[885,888],{"name":886,"role":32,"phone":10,"phoneExt":10,"email":887},"Ronaye Wagner","ronaye.wagner@ccnw.net",{"name":889,"role":28,"phone":10,"phoneExt":10,"email":10},"Dr. Jessica Hellyer, MD",{"facility":891,"status":38,"city":892,"state":893,"zip":894,"country":42,"countryCode":43,"cosmosGeoPoint":895,"geoPoint":899,"contacts":900},"ThedaCare Regional Cancer Center","Appleton","Wisconsin","54911",{"type":45,"coordinates":896},[897,898],-88.41538,44.26193,{"lat":898,"lon":897},[901,905],{"name":902,"role":32,"phone":903,"phoneExt":10,"email":904},"Rachel Luedtke","920-364-3616","Rachel.Luedtke@thedacare.org",{"name":906,"role":28,"phone":10,"phoneExt":10,"email":10},"Matthias Weiss, MD",{"facility":908,"status":38,"city":909,"state":893,"zip":910,"country":42,"countryCode":43,"cosmosGeoPoint":911,"geoPoint":915,"contacts":916},"Gundersen Health System","La Crosse","54601",{"type":45,"coordinates":912},[913,914],-91.23958,43.80136,{"lat":914,"lon":913},[917,921],{"name":918,"role":32,"phone":919,"phoneExt":10,"email":920},"Jennifer Cole","608-775-6694","jmcole@gundersenhealth.org",{"name":922,"role":28,"phone":10,"phoneExt":10,"email":10},"Benjamin Parsons, MD",{"type":924,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[926],{"name":927,"class":6},"AstraZeneca","100457401","gemini-nsclc-nsclc-biomarker-study-100457401",false,"NCT05236114","GEMINI-NSCLC: NSCLC Biomarker Study","TEMPUS GEMINI NSCLC STUDY: A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Non-Small Cell Lung Cancer (NSCLC)","For Cohort 1 Inclusion, the participant has\u002Fis:\n\n* A known or suspected NSCLC treated with curative intent -(surgery with or without perioperative (neoadjuvant or adjuvant) therapy).\n\n  * Suspected NSCLC - Patients with a high index of suspicion for the diagnosis of NSCLC that is resectable may sign informed consent prior to undergoing diagnostic procedure at the discretion of the physician. NCCN Guidelines allow for clinical stage IA cancers to proceed directly to definitive surgery. Per NCCN Guidelines, if a preoperative tissue diagnosis has not been obtained, then an intraoperative diagnosis will be obtained. If a diagnosis of NSCLC is not confirmed and\u002For the tumor is not resectable, then the patient will be a screen failure.\n* Undergone or planning to undergo a surgical resection - (Patients with stages I-IIIB who are resectable - per NCCN guidelines of resectability)\n* Both patients who lack molecular abnormalities and those with identified molecular abnormalities may enroll. Choice of perioperative therapy is to follow SOC therapeutic guidelines for the participant's molecular and PD-L1 profile.\n* 18 years old or older\n* Willing and able to provide informed consent\n* Willing to have additional blood samples collected during routine surveillance visits\n* Must submit tumor sample representative of current disease\n\nFor Cohort 1 Exclusion, the participant has\u002Fis:\n\n* Patients with superior sulcus tumors who are candidates for preoperative concurrent chemoradiation.\n* Stage III locally advanced and unresectable patients who are candidates for chemoradiation followed by immunotherapy.\n* It is expected that all patients on the cohort will be treated with a definitive surgical resection. Thus, clinical stage IIIB and IIIC patients who subsequently demonstrate pathologically confirmed N3 nodal disease or T4 N2 or 3 per any confirmatory procedure listed in NCCN guidelines for which definitive chemoradiotherapy rather than surgery is recommended per NCCN Guidelines are not eligible.\n* Patients who receive primary radiation (in lieu of surgery if they are not surgical candidates).\n\nFor Cohort 2 Inclusion, the participant has\u002Fis:\n\n* Histologically documented Stage IV NSCLC (de novo metastatic or relapse setting) not amenable to curative surgery or radiation therapy. Palliative radiation (for instance for impending bony fracture or to control pain) is allowed at any time during the protocol at the physician's discretion.\n* Intended to receive first line immunotherapy (as monotherapy or in combination with chemotherapy). Patients who have had previous exposure to immunotherapy in the neoadjuvant or adjuvant setting are allowed to enroll as long as 12 months have elapsed since the prior exposure.\n\n  * Patients in surveillance on Cohort 1 are eligible to roll over to Cohort 2 at the time of recurrence as long as they have had histologic confirmation of recurrence and have been off immunotherapy for 12 months or greater and meet all other inclusion\u002Fexclusion criteria.\n* Tumors that lack activating EGFR mutations (e.g., exon 19 deletion or exon 21 L858R, exon 21 L861Q, exon 18 G719X, or exon 20 S768I mutation) and ALK fusions. Also, per NCCN Guideline recommended testing, tumors must also lack ROS1, BRAF, NTRK 1\u002F2\u002F3, METex14 skipping mutations, and RET for which there is available front-line targeted therapy. Only those patients with KRAS G12C mutations and ERBB2 (HER2) mutations with no contraindications to immunotherapy (PD-L1 1) for which there are no approved front-line targeted therapies and for whom immunotherapy would be the preferred front-line therapy are eligible.\n* Patients may be enrolled with local molecular testing and those results will be provided.\n\n  * Patients may be enrolled with local molecular testing and those results will be provided.\n* 18 years and older\n* Willing and able to provide informed consent\n* Willing to have additional blood samples collected during routine surveillance visits\n* Must submit tumor sample representative of current disease\n\nExclusion Criteria (both Cohorts):\n\n* Patients without a known or suspected NSCLC diagnosis, or other disease processes such as sarcoidosis, lymphoma, or metastatic cancer from other sites.\n* Not willing to have additional blood samples collected\n* Patients with a secondary malignancy must have been both diagnosed \\> 2 years from the lung cancer of interest and have completed all therapy for that malignancy (including extended adjuvant therapy) \\> 2 years prior to diagnosis of the lung cancer of interest with the exception of the following:\n* Patients with superficial basal cell carcinoma of low-risk histology per NCCN Guidelines (Low-risk histologic subtypes include nodular, superficial, and other non-aggressive growth patterns such as keratotic, infundibulocystic, and fibroepithelioma of Pinkus) and low-risk for recurrence per NCCN Guidelines (location on trunk or extremities, size \\\u003C 2 cm, primary (not recurrent), with well-defined borders) can be included even if they are diagnosed \\\u003C 2 years from the lung cancer of interest.\n* Patients with superficial squamous cell carcinoma of low-risk pathology per NCCN Guidelines (verrucous, keratoacanthomatous) and low-risk for recurrence per NCCN Guidelines (located on trunk or extremities; 2 cm in size; primary lesion (vs. recurrent); well to moderately differentiated; \\\u003C 2 mm thick and no invasion beyond subcutaneous fat; negative for perineural invasion; and negative for lymphatic or vascular involvement) can be included even if they are diagnosed \\\u003C 2 years from the lung cancer of interest.","ALL","18 Years",{"count":938,"type":939},1200,"ESTIMATED","OBSERVATIONAL","GEMINI NSCLC Study is a non-interventional study that will be collecting clinical and molecular health information from patients with NSCLC who will receive longitudinal blood collection in addition to their standard of care therapy and disease surveillance with the goals of identifying the molecular evolution of lung cancer with standard of care therapy, and determining the utility of ctDNA dynamics to predict risk of recurrence and therapeutic outcomes.",[943],"Non-Small Cell Lung Cancer",[945,946,947,948,949,943,950,951,952],"Cancer","Oncology","Observational","Genomic Profiling","Precision medicine","NSCLC","NGS","Biomarkers","2026-02-03",{"date":955,"type":956},"2026-02-05","ACTUAL",{"date":958,"type":956},"2022-06-22",{"date":960,"type":939},"2029-06",{"name":5,"class":6},58]