[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100455454":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":43,"locations":49,"responsibleParty":65,"collaborators":10,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":10,"eligibilityCriteria":74,"healthyVolunteers":71,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Peking University First Hospital","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"propofol",null,"General anesthesia is induced and maintained mainly with propofol.",[13],"Drug: propofol",{"label":15,"type":10,"description":16,"interventionNames":17},"sevoflurane","General anesthesia is induced and maintained mainly with sevoflurane.",[18],"Drug: sevoflurane",{"label":20,"type":10,"description":21,"interventionNames":22},"ketamine","General anesthesia is induced mainly with S-ketamine and maintained mainly with propofol.",[23],"Drug: S-ketamine",[25,30,34],{"type":26,"name":9,"description":11,"armGroupLabels":27,"otherNames":28},"DRUG",[9],[29],"Propofol anesthesia group",{"type":26,"name":15,"description":16,"armGroupLabels":31,"otherNames":32},[15],[33],"Sevoflurane anesthesia group",{"type":26,"name":35,"description":21,"armGroupLabels":36,"otherNames":37},"S-ketamine",[20],[38],"S-ketamine anesthesia group",[40],{"name":41,"affiliation":5,"role":42},"Dong-Xin Wang, MD, PhD","STUDY_DIRECTOR",[44],{"name":45,"role":46,"phone":47,"phoneExt":10,"email":48},"Linlin Song, MD","CONTACT","86-13501309217","songlinlinlynkia@163.com",[50],{"facility":5,"status":51,"city":52,"state":10,"zip":10,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"RECRUITING","Beijing","China","CN",{"type":56,"coordinates":57},"Point",[58,59],116.39723,39.9075,{"lat":59,"lon":58},[62],{"name":63,"role":46,"phone":64,"phoneExt":10,"email":48},"Lin-Lin no Song, MD","86-010-83575138",{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dong-Xin Wang","Professor","100455454","general-anesthetics-related-changes-in-prefrontal-eeg-during-pediatric-surgical-anesthesia-100455454",false,"NCT05210764","General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia","Inclusion Criteria:\n\n* patients aged 0-18 years, American Society of Anesthesiologists Physical Status I-II, scheduled for elective surgery in Peking University First Hospital.\n\nExclusion Criteria:\n\n* Preterm patients;\n* Height and weight not within the standard ranges for respective ages;\n* Surgery for head or heart;\n* Patients with muscular, neurologic or psychiatric diseases;\n* Patients with Congenital anomaly or hereditary diseases;\n* Patients with medication abuse;\n* Allergy to medication including propofol, sevoflurane, and ketamine;\n* Allergy to beans;\n* Refusal to participate the study by guardians.","ALL","1 Minute","18 Years",{"count":79,"type":80},366,"ESTIMATED","OBSERVATIONAL","The change profiles of indices derived from pEEG such as phase-amplitude coupling and bicoherence based on individual general anesthetics in children have not been examined in previous literature. Whether those indices have the abilities to predict individual drug-related anesthesia depth in children need to be explored.",[84,85],"General Anesthetic","Electroencephalogram",[87,88],"general anesthetic","electroencephalogram","2025-07-28",{"date":91,"type":92},"2025-07-31","ACTUAL",{"date":94,"type":92},"2022-06-01",{"date":96,"type":80},"2026-08",{"name":5,"class":6},1]