[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100576521":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":10,"locations":23,"responsibleParty":48,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":10,"overallStatus":68,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"narcolepsy patients",null,"50 narcolepsy patients will be included in the study at Robert Debré Hospital",[13],"Genetic: saliva sampling",{"label":15,"type":10,"description":16,"interventionNames":17},"control patients","150 control patients will be included in the study at Robert Debré Hospital",[13],[19],{"type":20,"name":21,"description":21,"armGroupLabels":22,"otherNames":10},"GENETIC","saliva sampling",[15,9],[24],{"facility":25,"status":10,"city":26,"state":10,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Robert Debré Hospital","Paris","75019","France","FR",{"type":31,"coordinates":32},"Point",[33,34],2.3488,48.85341,{"lat":34,"lon":33},[37,42,46],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Michel LECENDREUX, MD","CONTACT","+331.40.03.20.00","michel.lecendreux@aphp.fr",{"name":43,"role":39,"phone":44,"phoneExt":10,"email":45},"Emmanuel MIGNOT, MD, PhD","(650) 725-6517","mignot@stanford.edu",{"name":38,"role":47,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100576521","genetic-and-clinical-characterization-of-type-1-and-2-narcolepsy-in-adult-and-pediatric-black-and-north-african-populations-100576521",false,"NCT06786377","Genetic and Clinical Characterization of Type 1 and 2 Narcolepsy in Adult and Pediatric Black and North African Populations","NarcoGen","Inclusion Criteria:\n\nNarcolepsy patients:\n\n* Individuals of black and North African origin diagnosed with NT1 or NT2.\n* Age ≥ 6 years\n* Clinical confirmation of narcolepsy according to the criteria of the International Classification of Sleep Disorders (ICSD-3).\n* Signature of informed consent by the adult patient or both holders of parental authority for minor patients.\n\nControl subjects:\n\n* Volunteers without pathology related to the study from the same ethnic or related groups with the aim of reaching two matched control subjects for each case.\n* Age ≥ 6 years\n* Signature of informed consent by the adult subject or both holders of parental authority for minor subjects.\n\nExclusion Criteria:\n\n* Individuals unable to understand the protocol or unwilling to participate.",true,"ALL","6 Years","21 Years",{"count":62,"type":63},200,"ESTIMATED","OBSERVATIONAL","Narcolepsy type 1 (NT1) is a neurological disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, and hallucinations while awake. It results from the loss of orexin-producing neurons in the hypothalamus, leading to a deficiency of the neuropeptide orexin\u002Fhypocretin. Studies show differences in the clinical presentation of NT1 between Caucasian and African American populations, highlighting the importance of research into genetic and clinical characteristics specific to Black and North African populations.\n\nA genetic study in these populations could identify novel genes associated with NT1 and NT2, providing crucial information for personalized diagnosis and treatment. This would fill a knowledge gap and promote more effective interventions for individuals of African descent, contributing to a better understanding of narcolepsy globally.",[67],"Narcolepsy","NOT_YET_RECRUITING","2025-01-15",{"date":71,"type":72},"2025-01-22","ACTUAL",{"date":74,"type":63},"2025-01-30",{"date":76,"type":63},"2026-01-30",{"name":5,"class":6},1]