[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555047":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":30,"responsibleParty":52,"collaborators":55,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Gødstrup Hospital","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Group 1",null,"Individuals with TS and SNHL",{"label":13,"type":10,"description":14,"interventionNames":10},"Group 2","Individuals with TS without SNHL",{"label":16,"type":10,"description":17,"interventionNames":10},"Group 3","Healthy age matched controls without TS and without SNHL",[19],{"name":20,"affiliation":21,"role":22},"Therese Ovesen, Prof","University Clinic of Flavour, Balance and Sleep","PRINCIPAL_INVESTIGATOR",[24],{"name":25,"role":26,"phone":27,"phoneExt":28,"email":29},"Louise Hill-Madsen, MD","CONTACT","20282635","0045","lohill@rm.dk",[31],{"facility":32,"status":33,"city":34,"state":10,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"ENT department of Gødstrup Hospital","RECRUITING","Herning","7400","Denmark","DK",{"type":39,"coordinates":40},"Point",[41,42],8.97662,56.13615,{"lat":42,"lon":41},[45,48,51],{"name":46,"role":26,"phone":47,"phoneExt":10,"email":29},"Louise Hill-Madsen, MD, PhD student","(45+) 78439744",{"name":49,"role":26,"phone":10,"phoneExt":10,"email":50},"Therese Ovesen, Professor","theroves@rm.dk",{"name":46,"role":22,"phone":10,"phoneExt":10,"email":10},{"type":22,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Louise Hill-Madsen","Medical Doctor",[56,58],{"name":57,"class":6},"University of Aarhus",{"name":59,"class":6},"Aarhus University Hospital","100555047","genetic-and-epigenetic-background-of-inner-ear-dysfunction-in-turner-syndrome-100555047",false,"NCT06507007","Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome","EPIHEAR","Inclusion Criteria:\n\n* age between 18 and 60 years old\n\nExclusion Criteria:\n\n* Contraindications for the MRI or CBCT\n* Serious medical disorders\n* Neurological or psychiatric disorders of any kind\n* Use of medication that is known to influence inner ear function\n* Medical history with dizziness or hearing problems (controls only)",true,"FEMALE","18 Years","60 Years",{"count":72,"type":73},150,"ESTIMATED","OBSERVATIONAL","The goal of this case-control study is to pave the way for new revolutionary treatment measures within hearing loss that could either replace or delay the need for hearing aids. The study focuses on people with Turner syndrome (TS).\n\nThe aim is to find out if there are specific DNA methylation patterns and\u002For RNA expression profiles linked to sensorineural hearing loss (SNHL) in people with TS. Additionally, the structure and function of the inner ear in these individuals will be examined to see if there is a connection to their epigenetic profile.\n\nThe main question it aims to answer is: Does epigenetics constitute a common denominator for some of the unexplained SNHL cases?\n\nTurner Syndrome (TS) represents an ideal model for studying epigenetics related to sensorineural hearing loss (SNHL).\n\nParticipants will undergo the following tests:\n\n* Ear examinations\n* Hearing tests\n* Balance tests\n* Blood tests\n* MRI scans\n* CBCT (cone-beam computed tomography) scans",[77,78,79],"Sensorineural Hearing Loss","Turner Syndrome","Inner Ear Disease",[81,82,78,83],"Epigenetics","Sensorineural hearing loss","Inner Ear Dysfunction","2026-01-24",{"date":86,"type":87},"2026-01-27","ACTUAL",{"date":89,"type":87},"2025-02-01",{"date":91,"type":73},"2027-07-30",{"name":5,"class":6},1]