[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100346617":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":12,"centralContacts":16,"locations":25,"responsibleParty":47,"collaborators":50,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":7,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":7,"studyType":66,"phases":7,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":28,"whyStopped":7,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"No Interventions","Not applicable - No Interventions",[13],{"name":14,"affiliation":5,"role":15},"Chandan K Sen, PhD","PRINCIPAL_INVESTIGATOR",[17,22],{"name":18,"role":19,"phone":20,"phoneExt":7,"email":21},"Piya Das Ghatak, PhD, MS","CONTACT","412-648-8297","piya.dasghatak@pitt.edu",{"name":23,"role":19,"phone":20,"phoneExt":7,"email":24},"Sashwati Roy, PhD","sar453@pitt.edu",[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"UPMC Wound Care Centers","RECRUITING","Pittsburgh","Pennsylvania","15213","United States","US",{"type":35,"coordinates":36},"Point",[37,38],-79.99589,40.44062,{"lat":38,"lon":37},[41,43],{"name":18,"role":19,"phone":42,"phoneExt":7,"email":21},"6149064621",{"name":44,"role":19,"phone":45,"phoneExt":7,"email":46},"Urmila Gnyawali, CCRP","614-371-2028","usg2@pitt.edu",{"type":15,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Chandan Sen","Professor",[51],{"name":52,"class":53},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100346617","genetic-and-epigenetic-basis-of-chronic-wounds-100346617",false,"NCT03793062","Genetic and Epigenetic Basis of Chronic Wounds","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Willing to comply with protocol instructions, including all study visits and study activities.\n* Chronic wounds (\\> than four weeks since onset)\n* Clinically diagnosed diabetic or non-diabetic ulcer.\n* For patients with multiple wounds, the largest wound will be used for the study.\n\nExclusion Criteria:\n\n* Individuals who are deemed unable to understand the procedures, risks and benefits of the study,(i.e. unable to provide informed consent)\n* Pregnant females (self-declared) or lactating\n* Subjects with marked immunodeficiency (HIV\u002FAIDS or immune-suppressive medications)\n* Prisoners","ALL","18 Years","100 Years",{"count":64,"type":65},256,"ESTIMATED","OBSERVATIONAL","This pilot study is designed for chronic wounds that fail to heal in a timely manner carry specific genetic signatures. These genetic signatures will be studied using debrided wound tissue that is removed by the wound care provider as part of standard of care. The reference genomic signature will be evaluated by obtaining blood samples and will be compared with wound debrided tissue genomic signature to understand wound specific genomic changes.",[69],"Chronic Wounds",[71,72,73,74,75],"genome","epigenome","chronic wounds","genetics","socioeconomic","2026-04-08",{"date":78,"type":79},"2026-04-14","ACTUAL",{"date":81,"type":79},"2018-12-04",{"date":83,"type":65},"2028-12-31",{"name":5,"class":6},1]