[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100495575":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":40,"centralContacts":45,"locations":54,"responsibleParty":71,"collaborators":10,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":10,"studyType":88,"phases":10,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":56,"whyStopped":10,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Biobank- samples from NMID patients",null,"600 samples from NMID patients from the Biobank Dermatology Unispital Basel (USB) (Biobank USB) and from the biobank of the Dermatology Department of the University Hospital Zürich (USZ) (Biobank USZ) will be included.",[13],"Other: Analysis of samples",{"label":15,"type":10,"description":16,"interventionNames":17},"Formalin-fixed and paraffin-embedded (FFPE) samples","About 50 of formalin-fixed and paraffin-embedded (FFPE) samples from the Dermatology USB collected before 2014 for RNA and protein expression analyses will be reused. The patients in questions are informed about the study and the coded use of their samples.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Biobank- samples from controls","2'700 anonymized control genomes as well as 150 anonymized control samples for the proteomics approach can be used as control samples from the biobank of the Dermatology Department of the University Hospital Zürich (Biobank Dermatology USZ).",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Fresh skin samples from healthy donors","A maximum of 20 fresh skin samples from healthy donors are required per skin location. They will be requested from healthy volunteers after information about the study and receiving the informed consent.",[13],[27,31,34,37],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Analysis of samples","DNA extraction from blood or saliva samples for the identification of gene variants by next generation sequencing;",[9,19,15,23],{"type":6,"name":28,"description":32,"armGroupLabels":33,"otherNames":10},"RNA extraction from blood and skin samples for Nanostring analyses, quantitative RT-PCR or RNA sequencing.",[9,19,15,23],{"type":6,"name":28,"description":35,"armGroupLabels":36,"otherNames":10},"Biobanked skin samples will be analyzed by immunostaining and imaging techniques to identify cell types in lesions and compare them to healthy skin.",[9,19,15,23],{"type":6,"name":28,"description":38,"armGroupLabels":39,"otherNames":10},"Cells isolated from biobanked blood and skin samples will be cultured in vitro and proteins will be analyzed by ELISA (secreted proteins) and western blot (cell proteins).",[9,19,15,23],[41],{"name":42,"affiliation":43,"role":44},"Alexander Navarini, Prof. Dr. med.","University Hospital Basel, Clinic of Dermatology","PRINCIPAL_INVESTIGATOR",[46,50],{"name":42,"role":47,"phone":48,"phoneExt":10,"email":49},"CONTACT","+41 61 265 40 84","alexander.navarini@usb.ch",{"name":51,"role":47,"phone":52,"phoneExt":10,"email":53},"Emmanuel Contassot, Dr.","+41 61 328 55 45","emmanuel.contassot@usb.ch",[55],{"facility":43,"status":56,"city":57,"state":10,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"RECRUITING","Basel","4031","Switzerland","CH",{"type":62,"coordinates":63},"Point",[64,65],7.57327,47.55839,{"lat":65,"lon":64},[68,69,70],{"name":42,"role":47,"phone":48,"phoneExt":10,"email":49},{"name":51,"role":47,"phone":52,"phoneExt":10,"email":53},{"name":42,"role":44,"phone":10,"phoneExt":10,"email":10},{"type":72,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100495575","genetic-architecture-of-neutrophil-mediated-inflammatory-skin-diseases-100495575",false,"NCT05732987","Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases","Case-Control Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases","NEUTROSKIN","Inclusion Criteria:\n\n* written consent of the participating person\n* diagnosis of a disease in the NMID form group or proband of the control group\n\nExclusion Criteria for patients:\n\n* Missing informed consent if samples collected after 2014\n* no diagnosis of NMID\n\nExclusion Criteria for healthy controls:\n\n* Missing informed consent",true,"ALL","18 Years","100 Years",{"count":86,"type":87},3370,"ESTIMATED","OBSERVATIONAL","This study is to identify rare, disease-causing mutations of several rare neutrophil dermatoses. To identify associations between NMID and variants in the genome next generation sequencing, mainly whole exome sequencing, will be used. In a second approach the expression level of already known inflammatory proteins in skin samples will be investigated.",[91,92],"Neutrophil-mediated Inflammatory Dermatoses","Inflammatory Dermatoses",[94,95,96,97],"inflammasome","inflammation-driving pathway","gene variants","next generation sequencing","2023-08-21",{"date":100,"type":101},"2023-08-22","ACTUAL",{"date":103,"type":101},"2023-02-03",{"date":105,"type":87},"2029-09",{"name":5,"class":6},1]