[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100366094":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":59,"collaborators":10,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":10,"maxAge":10,"enrollmentInfo":69,"targetDuration":10,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University Hospital Tuebingen","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"Healthy twin",null,[12],"Genetic: NGS Diagnostic",{"label":14,"type":10,"description":15,"interventionNames":16},"Effected Twin","Twin with unclear rare diseases, clinically characterized in the context of outpatient\u002F inpatient standard care at the University Hospital Tübingen (UKT) or cooperating location.",[12],[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"GENETIC","NGS Diagnostic","Blood take for genetic diagnostic.",[14,9],[24],"Omics Technology",[26],{"name":27,"affiliation":28,"role":29},"Jeannette Hübener-Schmid, Dr.","University Hospital Tübingen","PRINCIPAL_INVESTIGATOR",[31,36],{"name":27,"role":32,"phone":33,"phoneExt":34,"email":35},"CONTACT","+49 7071 29","72276","jeannette.huebener@med.uni-tuebingen.de",{"name":37,"role":32,"phone":33,"phoneExt":38,"email":39},"Andreas Dufke, PD Dr.","86413","andreas.dufke@med.uni-tuebingen.de",[41],{"facility":28,"status":42,"city":43,"state":10,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Tübingen","72076","Germany","DE",{"type":48,"coordinates":49},"Point",[50,51],9.05222,48.52266,{"lat":51,"lon":50},[54,57],{"name":27,"role":32,"phone":55,"phoneExt":56,"email":35},"+49 7071-297","2276",{"name":37,"role":32,"phone":55,"phoneExt":58,"email":39},"2190",{"type":60,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100366094","genetic-causes-of-discrepant-clinic-in-monogenic-twins-100366094",false,"NCT04046796","Genetic Causes of Discrepant Clinic in Monogenic Twins","DISCO-TWIN","Inclusion Criteria:\n\n* Twin pair monozygotic clinically (phenotypic) discordant twins\n* Unclear diagnosis\n* Suspected (mono-)genetic cause of the disease in one twin\n\nExclusion Criteria:\n\n* Missing informed consent of both twin\u002F legal representative\n* No distinct phenotype","ALL",{"count":70,"type":71},50,"ESTIMATED","OBSERVATIONAL","In the DISCO-TWIN study (prospective, open-label molecular-genetic study), twin pairs with one healthy and one affected twin with molecularly undiagnosed diseases will be analysed by means of omics technologies and\u002F or re-analysed using existing datasets. Phenotype and omics data will be shared within the University Hospital Tübingen and with external collaborators to improve the diagnostic rate of the subjects included in the study.",[75,76],"Rare Diseases","Genetic Predisposition to Disease",[75,78,24,79],"Genetic Predisposition","Next Generation Sequencing (NGS)","2025-03-25",{"date":82,"type":83},"2025-03-30","ACTUAL",{"date":85,"type":83},"2019-12-01",{"date":87,"type":71},"2027-12",{"name":5,"class":6},1]