[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100331881":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":38,"responsibleParty":58,"collaborators":18,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":18,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":85,"overallStatus":40,"whyStopped":18,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Nova Scotia Health Authority","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Genetic counselling","EXPERIMENTAL","Eligible participants who are randomized will be contacted and offered an invitation to attend the intervention. Genetic counselling will be provided to participants who accept the intervention as a single 1-2 hour session by a board-certified genetic counsellor. During the genetic counselling session, participants will have the option to receive their genotype at rs2494732. Participants will be counselled regarding their individualized risk of developing and of NOT developing SMI based on family history, whether or not they choose to use cannabis, and genotype (if they accept the genetic test results). Approximately 1 month after the intervention, participants will receive a follow-up interview.",[13],"Behavioral: Genetic counselling",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","Eligible participants who are not randomized to be offered the intervention will continue with their annual assessments as part of the parent study. These participants will receive the current standard of care (no intervention), and will not be offered or informed of the intervention.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"BEHAVIORAL","Participants will receive information on risk\u002Fprotective factors and causes of mental illness. Participants are not required to receive numeric\u002Fgenetic risk information. Participants who choose to receive genetic and\u002For numeric risk information will be counselled on their risk of NOT developing and of developing SMI based on their genetic test results and\u002For family history information they provide. Risk estimates will be derived by genetic counsellors, according to standard practice guidelines. Participants who receive genetic information will be counselled on the possible influence of cannabis use on risk of mental illness based on their genotype. Participants who choose to not receive genetic information will be counselled on the influence of cannabis on mental health.",[9],[25],{"name":26,"affiliation":27,"role":28},"Rudolf Uher, MD, PhD","Nova Scotia Health Authority, Dalhousie University","PRINCIPAL_INVESTIGATOR",[30,34],{"name":26,"role":31,"phone":32,"phoneExt":18,"email":33},"CONTACT","902-473-7209","uher@dal.ca",{"name":35,"role":31,"phone":36,"phoneExt":18,"email":37},"Jill M Cumby, RN, MN","902-473-1781","Jill.Cumby@nshealth.ca",[39],{"facility":5,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Halifax","Nova Scotia","B3H 2E2","Canada","CA",{"type":47,"coordinates":48},"Point",[49,50],-63.57688,44.64269,{"lat":50,"lon":49},[53,55],{"name":54,"role":31,"phone":18,"phoneExt":18,"email":33},"Rudolf Uher, MD PhD",{"name":56,"role":31,"phone":18,"phoneExt":18,"email":57},"Jill Cumby, RN","jill.cumby@nshealth.ca",{"type":59,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100331881","genetic-counselling-in-the-prevention-of-mental-health-consequences-of-cannabis-use-100331881",false,"NCT03601026","Genetic Counselling in the Prevention of Mental Health Consequences of Cannabis Use","Interdisciplinary Approach to Maximize Adolescent Potential: Genetic Counselling Interventions to Reduce Negative Environmental Effects","IMAGINE","Inclusion Criteria:\n\n* Enrolment in the Families Overcoming Risks and Building Opportunities for Well-being (FORBOW) study.\n* Age between 12 and 21 years.\n* Knowledge of English sufficient to benefit from the intervention.\n* Capacity to provide informed consent at most recent FORBOW assessment.\n* Provision of consent to be contacted about future studies at most recent FORBOW assessment.\n\nExclusion Criteria:\n\n* A diagnosis of severe mental illness (psychotic disorder, bipolar disorder, severe\u002Frecurrent depression) at baseline\n* Autism or intellectual disability of a degree that interferes with assessment (IQ \\\u003C 70)","ALL","12 Years","21 Years",{"count":72,"type":73},120,"ESTIMATED","INTERVENTIONAL",[76],"NA","Severe mental illness (SMI) refers to the most burdensome psychiatric conditions. The need to pre-empt the onset of SMI is pressing because once SMI develops, quality of life is poor and available treatments have limited efficacy. Most risk factors for SMI are either unchangeable (e.g., genetics) or difficult to alter (e.g., low socio-economic status). In contrast, cannabis use is one specific risk factor that could be avoided. Certain individuals are more vulnerable to the harmful effects of cannabis. Genetic factors can help us identify these high-risk individuals. One in three individuals are carriers of a higher-risk genetic variant, and cannabis users with this genotype are at up to 7-fold increased risk of developing schizophrenia. In our study, genetic counselling will be provided to participants by a board-certified genetic counsellor. During the genetic counselling session, participants will have the option to receive their genotype. Participants will be counselled regarding their individualized risk of developing and of not developing SMI based on family history, whether or not they choose to use cannabis, and genotype (if the participants accept the genetic test results). The investigators hypothesize that this intervention will reduce exposure to cannabis compared to the youth who are not offered the intervention.",[79,80,81,82,83,84],"Mental Illness","Schizophrenia","Bipolar Disorder","Major Depressive Disorder","Cannabis Use","Psychosis",[86,87,88,9,89,90],"Severe mental illness","Developmental psychopathology","Trial-within-cohort","Cannabis use","Prevention","2025-05-13",{"date":93,"type":94},"2025-05-14","ACTUAL",{"date":96,"type":94},"2019-11-01",{"date":98,"type":73},"2027-09-01",{"name":5,"class":6},1]