[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100410114":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":18,"locations":23,"responsibleParty":37,"collaborators":7,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":7,"eligibilityCriteria":44,"healthyVolunteers":41,"sex":45,"minAge":7,"maxAge":7,"enrollmentInfo":46,"targetDuration":49,"studyType":50,"phases":7,"briefSummary":51,"conditions":52,"keywords":55,"overallStatus":58,"whyStopped":7,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"The University of Texas Health Science Center at San Antonio","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"GENETIC","DNA or RNA Sequencing","Samples will be used for whole exome (DNA) or RNA sequencing",[14],{"name":15,"affiliation":16,"role":17},"Patricia L Dahia, MD, PhD","University of Texas Health at San Antonio","PRINCIPAL_INVESTIGATOR",[19],{"name":15,"role":20,"phone":21,"phoneExt":7,"email":22},"CONTACT","210-567-4866","dahia@uthscsa.edu",[24],{"facility":25,"status":7,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":7},"University of Texas Health Science Center","San Antonio","Texas","78229","United States","US",{"type":32,"coordinates":33},"Point",[34,35],-98.49363,29.42412,{"lat":35,"lon":34},{"type":38,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100410114","genetic-investigation-of-cancer-predisposition-100410114",false,"NCT04620278","Genetic Investigation of Cancer Predisposition","Inclusion Criteria:\n\n1. Any age\n2. Meets at least ONE of the following:\n\n   1. Personal history (with documented diagnosis) of cancer before the age of 50\n   2. Personal history of more than one primary cancer\n   3. Documented diagnosis of cancer AND family history of that same cancer type or multiple other cancers that do not fit classical criteria of hereditary cancer syndromes\n   4. Documented diagnosis of a rare cancer AND family history of rare cancers that do not fit classical criteria of hereditary cancer syndromes\n   5. There is the same type of cancer in several generations of a family\n   6. Documented diagnosis of multicentric cancers (e.g bilateral cancers in paired organs, or multifocal cancers in single organs) that usually occur as single lesions when presented sporadically\n   7. Early onset cancer (before the age of 50, or breast cancer before age 45) AND family history of early onset cancer Capable of providing access to detailed medical records and family history of cancer\n\nExclusion Criteria:\n\n1. Established genetic diagnosis of a known hereditary cancer syndrome that is compatible with the clinical presentation\n2. Incarcerated","ALL",{"count":47,"type":48},100,"ESTIMATED","60 Months","OBSERVATIONAL","Clinical information and samples (blood, saliva, and tumor) will be collected from patients with multiple cancers and\u002For a family history of cancer as well as from affected and unaffected relatives; samples will be systematically sequenced and evaluated for candidate driver mutations.",[53,54],"Genetic Predisposition","Cancer",[56,57],"Genetic analysis","Early diagnosis","NOT_YET_RECRUITING","2026-01-02",{"date":61,"type":62},"2026-01-06","ACTUAL",{"date":64,"type":48},"2026-10",{"date":66,"type":48},"2035-12",{"name":5,"class":6},1]