[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638903":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":15,"responsibleParty":36,"collaborators":10,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":10,"eligibilityCriteria":45,"healthyVolunteers":42,"sex":46,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":10,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":18,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"Second Xiangya Hospital of Central South University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with diabetes who 'progress to insulin deficiency and severe insulin deficiency'",null,"Patients with diabetes who 'progress to insulin deficiency' and 'progress to severe insulin deficiency'",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients who have not progressed to insulin deficiency","For each case, several controls (1:2) were randomly selected from patients in this cohort who had not progressed to insulin deficiency at the same follow - up time point.",[16],{"facility":17,"status":18,"city":19,"state":20,"zip":21,"country":22,"countryCode":23,"cosmosGeoPoint":24,"geoPoint":29,"contacts":30},"Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University","RECRUITING","Changsha","Hunan","410011","China","CN",{"type":25,"coordinates":26},"Point",[27,28],112.97087,28.19874,{"lat":28,"lon":27},[31],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},"Yang Xiao, MD\u002FPhD","CONTACT","86-0731-85292154","xiaoyang29@csu.edu.cn",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Yang Xiao","Professor, Department of Metabolism and Endocrinology, Institute of Metabolism and Endocrinology, National Clinical Research Center for Endocrine and Metabolic Diseases, Second Xiangya Hospital, Central South University","100638903","genetic-risk-score-of-type-1-diabetes-mellitus-for-progression-to-insulin-in-diabetic-patients-lack-of-predictive-value-a-multicenter-nested-case-control-study-100638903",false,"NCT07621445","Genetic Risk Score of Type 1 Diabetes Mellitus for Progression to Insulin in Diabetic Patients Lack of Predictive Value: a Multicenter Nested Case-control Study","Inclusion Criteria:\n\n* Gender is not restricted.\n* Age ranges from 14 to 50 years old.\n* Diagnosis of diabetes within \\\u003C 1 year:\n\n  1. If there are diabetes symptoms and meet any of the following criteria:① Plasma glucose at any time ≥ 11.1 mmol\u002FL (200 mg\u002FdL), or② Fasting plasma glucose ≥ 7.0 mmol\u002FL (126 mg\u002FdL), or③ Plasma glucose 2 hours after OGTT\u002Fpost - meal ≥ 11.1 mmol\u002FL (200 mg\u002FdL), or④ HbA1c ≥ 6.5%.\n  2. If there are no diabetes symptoms, another test on a different day is required for diagnosis.\n* Newly - diagnosed diabetes patients whose type diagnosis is considered unclear clinically.\n\nExclusion Criteria:\n\n* Peak C-peptide \\\u003C 200 pmol\u002FL;\n* Gestational diabetes, monogenic diabetes (neonatal diabetes, MODY), exocrine pancreatic diseases (cystic fibrosis), diabetes caused by drugs or chemicals;\n* Those who have been under long-term treatment with hormones or immunosuppressants;\n* Pregnant or lactating women;\n* Those with concurrent malignant tumors or severe heart, liver, and kidney diseases;\n* Those with an expected survival time of less than 3 years;\n* Those with mental disorders or unable to cooperate with the investigation for other reasons;\n* Acute phase of diabetic ketoacidosis;\n* Stress conditions such as severe infection, fever, trauma, and major surgery;\n* Patients lacking major clinical information;\n* Those considered by the researcher as unfit to participate in this study.","ALL","14 Years","50 Years",{"count":50,"type":51},2950,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to evaluate the predictive value of the genetic risk score for type 1 diabetes in the progression to insulin deficiency in diabetic patients. The main question it aims to answer is:\n\n1. To investigate the predictive efficacy of the genetic risk score for T1DM in determining whether diabetic patients will progress to insulin deficiency;\n2. To compare the differences in genetic characteristics between the insulin-deficient cohort and the non-insulin-deficient cohort.\n\nThis study is a nested case-control study, in which a case group and a control group are set up for the collection of observational indicators. Case group: Diabetic patients who \"progressed to insulin deficiency\" and those who \"progressed to severe insulin deficiency\". Control group: Patients who did not progress to insulin deficiency. The study period is 3 years.",[55,56],"Diabetes Mellitus","Diabetes Mellitus, Type 1",[58],"Genetic risk score","2026-05-31",{"date":61,"type":62},"2026-06-02","ACTUAL",{"date":64,"type":62},"2025-10-27",{"date":66,"type":51},"2029-12-31",{"name":5,"class":6},1]