[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100432111":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":42,"centralContacts":46,"locations":52,"responsibleParty":71,"collaborators":73,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":10,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":86,"minAge":87,"maxAge":10,"enrollmentInfo":88,"targetDuration":10,"studyType":91,"phases":10,"briefSummary":92,"conditions":93,"keywords":98,"overallStatus":55,"whyStopped":10,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Columbia University","OTHER",[8,16,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Mild Cognitive Impairment",null,"Individuals with mild cognitive impairment that began before age 70",[13,14,15],"Genetic: Blood draw","Other: Neurocognitive testing","Other: Medical questionnaire",{"label":17,"type":10,"description":18,"interventionNames":19},"Dementia\u002FAlzheimer's Disease","Individuals with Alzheimer's Disease or other dementia that began before age 70",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"Cognitively Healthy","Cognitively healthy individuals over the age of 35 years with a family history of dementia.",[13,14,15],{"label":25,"type":10,"description":26,"interventionNames":27},"Early-onset dementia prior to the age of 65.","Individuals diagnosed with early-onset dementia prior to the age of 65.",[13,14,15],[29,34,38],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"GENETIC","Blood draw","Blood draw for identification of genetic variants associated with the development of memory problems",[21,17,25,9],{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":10},"Neurocognitive testing","Brief memory test",[21,17,25,9],{"type":6,"name":39,"description":40,"armGroupLabels":41,"otherNames":10},"Medical questionnaire","Collection of medical history",[21,17,25,9],[43],{"name":44,"affiliation":5,"role":45},"Christiane Reitz, MD, PhD","PRINCIPAL_INVESTIGATOR",[47],{"name":48,"role":49,"phone":50,"phoneExt":10,"email":51},"Pamela Del Rosario","CONTACT","212-304-7284","pd2727@cumc.columbia.edu",[53],{"facility":54,"status":55,"city":56,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Columbia University Irving Medical Center","RECRUITING","New York","10032","United States","US",{"type":61,"coordinates":62},"Point",[63,64],-74.00597,40.71427,{"lat":64,"lon":63},[67,69],{"name":68,"role":49,"phone":50,"phoneExt":10,"email":51},"Pamela del Rosario, MD",{"name":70,"role":45,"phone":10,"phoneExt":10,"email":10},"Christiane Reitz, MD PhD",{"type":45,"investigatorFullName":44,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Associate Professor of Neurology and Epidemiology",[74,76],{"name":75,"class":6},"University of Miami",{"name":77,"class":78},"National Institute on Aging (NIA)","NIH","100432111","genetic-studies-of-early-onset-dementia-100432111",false,"NCT04906863","Genetic Studies of Early-onset Dementia","Inclusion criteria:\n\n* 35 years and older\n* Individuals experiencing memory concerns or diagnosed with dementia and their family members that are unrelated healthy controls without dementia.\n\nExclusion Criteria:\n\n\\- Individuals with competing diagnosis such as Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc., unless family members of a dementia affected individual",true,"ALL","35 Years",{"count":89,"type":90},1000,"ESTIMATED","OBSERVATIONAL","The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.",[94,95,96,97],"Dementia, Early Onset","Alzheimer Dementia (AD)","Mild Cognitive Impairment (MCI)","Memory Loss",[99,100,101,102,103,104,105],"Alzheimer's Disease","Memory loss","Early-onset Alzheimer's disease","Mild cognitive impairment","Normal cognition","Dementia","Genetics","2026-04-24",{"date":108,"type":109},"2026-04-29","ACTUAL",{"date":111,"type":109},"2016-09-14",{"date":113,"type":90},"2028-04-30",{"name":5,"class":6},1]