[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100111031":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":26,"locations":35,"responsibleParty":57,"collaborators":10,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":10,"maxAge":10,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Medical College of Wisconsin","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"VLBW",null,"infants less than 1500 grams at birth",[13],"Genetic: gene variations",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"GENETIC","gene variations","comparing variations in genes in infants who develop chronic lung disease and other diseases of prematurity and those who do not.",[9],[21],"toll like receptors, biomarkers",[23],{"name":24,"affiliation":5,"role":25},"G. Ganesh Konduri, MD","PRINCIPAL_INVESTIGATOR",[27,31],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":30},"CONTACT","414.266.6820","gkonduri@mcw.edu",{"name":32,"role":28,"phone":33,"phoneExt":10,"email":34},"Kathleen M Meskin, BSN","414.337.7171","kmeskin@mcw.edu",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Children's Wisconsin","RECRUITING","Milwaukee","Wisconsin","53226","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-87.90647,43.0389,{"lat":48,"lon":47},[51,53,56],{"name":24,"role":28,"phone":52,"phoneExt":10,"email":30},"414-266-6820",{"name":54,"role":28,"phone":55,"phoneExt":10,"email":34},"Kathleen Meskin, RN, BSN","414-337-7171",{"name":24,"role":25,"phone":10,"phoneExt":10,"email":10},{"type":25,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"G. Ganesh Konduri","Chief, Division of Neonatology; Professor","100111031","genetic-variants-and-susceptibility-to-diseases-of-prematurity-in-very-low-birth-weight-infants-100111031",false,"NCT00710112","Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants","CLD","Inclusion Criteria:\n\n* Infants born weighing less than 1500 grams\n\nExclusion Criteria:\n\n* Infants born with congenital heart disease (other than patent ductus arteriosus)\n* major congenital anomalies of the GI tract, respiratory tract, or kidneys","ALL",{"count":69,"type":70},1100,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to determine if sequence variations in genes involved in the development and function of vulnerable organs increases susceptibility to chronic lung disease (CLD) and other diseases affecting premature infants, such as necrotizing enterocolitis (NEC), sepsis, patent ductus arteriosus (PDA) and intraventricular hemorrhage (IVH). The study will also determine whether measurement of certain biomarkers in serum will identify infants who will develop these complications of prematurity. Previous studies from this institution and others have identified genetic variants in some genes, such as toll like receptor genes are associated with higher risk of CLD or NEC. The interaction of these variants with other gene variants that can influence the risk of these diseases remains unclear.",[74],"Chronic Lung Disease",[65,76,77,78],"VLBW infants","Toll like Receptors","Biomarkers","2026-01-23",{"date":81,"type":82},"2026-01-26","ACTUAL",{"date":84,"type":10},"2006-06",{"date":86,"type":70},"2028-06",{"name":5,"class":6},1]