[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561826":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":10,"centralContacts":21,"locations":31,"responsibleParty":86,"collaborators":89,"id":98,"slug":99,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":106,"sex":107,"minAge":108,"maxAge":10,"enrollmentInfo":109,"targetDuration":112,"studyType":113,"phases":10,"briefSummary":114,"conditions":115,"keywords":118,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},{"fullName":5,"class":6},"Azienda Ospedaliero-Universitaria di Modena","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"affected twins",null,[12],"Other: multiomic profile to assess genetic and environmental risk factiors",{"label":14,"type":10,"description":10,"interventionNames":15},"unaffected twins",[12],[17],{"type":6,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"multiomic profile to assess genetic and environmental risk factiors","Genomic, epigenetic, proteomic, microbiome, immunology, biomarker, metabolite, pesticide, metal, and metalloid investigations will be conducted. The twins will be followed longitudinally from a clinical perspective, with biological sample collections to assess discordance and identify early disease signatures in unaffected individuals.",[9,14],[22,28],{"name":23,"role":24,"phone":25,"phoneExt":26,"email":27},"Jessica Mandrioli, MD, Prof","CONTACT","0593961640","+39 059 396164","jessica.mandrioli@unimore.it",{"name":29,"role":24,"phone":25,"phoneExt":26,"email":30},"Cecilia Simonini, BSc","ceciliasimonini24@gmail.com",[32,55,70],{"facility":5,"status":33,"city":34,"state":35,"zip":36,"country":35,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Modena","Italy","41125","IT",{"type":39,"coordinates":40},"Point",[41,42],10.92539,44.64783,{"lat":42,"lon":41},[45,47,50,52],{"name":29,"role":24,"phone":25,"phoneExt":46,"email":30},"0039",{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},"Ilaria Martinelli, MD, PhD","SUB_INVESTIGATOR",{"name":51,"role":49,"phone":10,"phoneExt":10,"email":10},"Elisabetta Zucchi, MD",{"name":53,"role":54,"phone":10,"phoneExt":10,"email":10},"Giulia Gianferrari, MD","PRINCIPAL_INVESTIGATOR",{"facility":56,"status":33,"city":57,"state":35,"zip":58,"country":35,"countryCode":37,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Azienda Ospedaliero-Universitaria Policlinico P. Giaccone di Palermo","Palermo","90127",{"type":39,"coordinates":60},[61,62],13.3636,38.1166,{"lat":62,"lon":61},[65,69],{"name":66,"role":24,"phone":67,"phoneExt":46,"email":68},"Tommaso Piccoli, MD","0649977000","tommaso.piccoli@unipa.it",{"name":66,"role":54,"phone":10,"phoneExt":10,"email":10},{"facility":71,"status":33,"city":72,"state":35,"zip":73,"country":35,"countryCode":37,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino","Torino","10126",{"type":39,"coordinates":75},[76,77],11.99138,44.88856,{"lat":77,"lon":76},[80,84],{"name":81,"role":24,"phone":82,"phoneExt":46,"email":83},"Cristina Moglia, MD","0116335439","cristina.moglia@unito.it",{"name":85,"role":49,"phone":10,"phoneExt":10,"email":10},"Umberto Manera, MD, PhD",{"type":54,"investigatorFullName":87,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"JESSICA MANDRIOLI","Prof",[90,92,94,96],{"name":91,"class":6},"A.O.U. Città della Salute e della Scienza - Molinette Hospital",{"name":93,"class":6},"Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo",{"name":95,"class":6},"University of Modena and Reggio Emilia",{"name":97,"class":6},"Azienda Ospedaliero-Universitaria Careggi","100561826","genetics-and-environment-intersection-in-the-als-ftd-spectrum-an-italian-twins-cohort-study-with-a-multi-omics-approach-100561826",false,"NCT06595212","Genetics and Environment iNtersection In the ALS-FTD Spectrum: an Italian Twins Cohort studY With a Multi-Omics Approach","Genetics and Environment iNtersection In the Amyotrophic Lateral Sclerosis - FrontoTemporal Dementia Spectrum: an Italian Twins Cohort studY With a Multi-Omics Approach","GENIALITY","Inclusion Criteria:\n\n* Age \\>18 yrs\n* Presence of MZ or DZ twins in the family both willing to participate in the study and able to provide informed consent\n* At least one twin is affected by ALS as defined by Gold Coast Criteria (Shefner et al., 2020) and\u002For by FTD as defined by Strong and colleagues (Strong et al., 2017)\n* Subjects able and willing to comply with study procedures as per protocol\n* Subjects able to understand, and capable of providing informed consent at screening visit before any protocol-specific procedures\n\nExclusion Criteria:\n\n* Unwillingness to perform assessments as stated in the protocol at least during baseline visit for both twins\n* Unwillingness to donate biological samples collected at periphery (lumbar puncture excluded) for both twins\n* Women who are pregnant or breastfeeding",true,"ALL","18 Years",{"count":110,"type":111},45,"ESTIMATED","24 Months","OBSERVATIONAL","The goal of this study is to learn from discordant twins affected by Amyotrophic Lateral Sclerosis and\u002For Frontotemporal Dementia the contribution of genetic background versus environmental exposure. The main questions it aims to answer is:\n\n* How far does the genetic background explain the onset of ALS\u002FFTD in discordant twins?\n* Which environmental factors and events occurring in post-fetal life influence the onset or progression of this neurodegenerative condition? Participants with ALS and\u002For FTD with a monozygotic or dizygotic twin willing to contribute to this research will be followed up for two years by specialized Motor Neuron Disorders centers in Italy, donating biological specimen for -omic sciences analysis, and checking out if prodromal signs\u002Fsymptoms of these two conditions will develop during time.",[116,117],"ALS","FTD",[116,117,119,120],"twin","cohort","2025-01-31",{"date":123,"type":124},"2025-02-04","ACTUAL",{"date":126,"type":124},"2024-01-29",{"date":128,"type":111},"2026-01-30",{"name":5,"class":6},3]