[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100147550":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":29,"responsibleParty":45,"collaborators":48,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":10,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":10,"maxAge":10,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Nationwide Children's Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Study Subjects",null,"Individuals with Congenital Heart Disease and family members with or without Congenital Heart Disease. A blood sample collection will be required for all study participants.",[13],"Other: Blood Sample Collection",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Blood Sample Collection","Blood sample collection for direct sequencing, microarray, single nucleotide polymorphism, whole-genome array comparative genomic hybridization DNA analyses, and\u002For whole exome or genome sequencing.",[9],[20],{"name":21,"affiliation":5,"role":22},"Vidu Garg, MD","PRINCIPAL_INVESTIGATOR",[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Katherine M Spayde, MS, CGC","CONTACT","614-355-6388","katherine.spayde@nationwidechildrens.org",[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Columbus","Ohio","43205","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-82.99879,39.96118,{"lat":41,"lon":40},[44],{"name":21,"role":22,"phone":10,"phoneExt":10,"email":10},{"type":22,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Vidu Garg","Director and Professor",[49],{"name":50,"class":51},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100147550","genetics-of-congenital-heart-disease-100147550",false,"NCT01192048","Genetics of Congenital Heart Disease","Genetic Testing of Individuals and Families With Congenital Heart Disease","Inclusion Criteria:\n\n* Subjects must have a diagnosis of Congenital Heart Disease or be related to individuals with Congenital Heart Disease.\n\nExclusion Criteria:\n\n* Healthy individuals unrelated to those with Congenital Heart Disease",true,"ALL",{"count":62,"type":63},5000,"ESTIMATED","OBSERVATIONAL","Congenital heart disease (CHD) is the most common type of birth defect but the cause for the majority of cardiac birth defects remains unknown. Numerous epidemiologic studies have demonstrated evidence that genetic factors likely play a contributory, if not causative, role in CHD. While numerous genes have been identified by us and other investigators using traditional genetic approaches, these genes account for a minority of the non-syndromic CHDs. Therefore, we are now utilizing whole genome sequencing (WGS), with the addition of more traditional genetic techniques such as chromosomal microarray or traditional linkage analysis, to identify genetic causes of familial and isolated CHD. With WGS we are able to sequence all of the genetic material of an individual and apply different data analysis techniques based on whether we are analyzing a multiplex family or a cohort of trios (mother, father and child with CHD) with a specific isolated CHD. Therefore, WGS is a robust method for identification of novel genetic causes of CHD which will have important diagnostic and therapeutic consequences for these children.",[67],"Congenital Heart Disease",[67,69,70,71,72,73,74,75,76,77,78,79,80,81],"birth defect","genetics","gene","DNA","direct sequencing","microarray","single nucleotide polymorphism","whole genome array comparative genomic hybridization","chromosomal copy number change","nucleotide sequence variation","exome sequencing","whole exome sequencing","whole genome sequencing","2026-04-01",{"date":84,"type":85},"2026-04-07","ACTUAL",{"date":87,"type":10},"2009-12",{"date":89,"type":63},"2030-12",{"name":5,"class":6},1]