[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100178744":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":30,"responsibleParty":49,"collaborators":52,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":10,"maxAge":10,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":78,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Centre Hospitalier Universitaire Vaudois","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients",null,"Patients with reproductive disorders with or without cleft lip\u002Fpalate will be recruited for:\n\n* completion of medical questionnaire and review of medical records\n* family tree (including questions on reproductive disorders and cleft lip\u002Fpalate)\n* specimen collection (DNA\u002FRNA) from: serum\u002Fplasma\u002Fsaliva\u002Furine\u002Fbuccal swab\u002Fhair follicles\u002Fsperm\u002Fskin biopsy\n* smell testing\n* hearing test\n* bone density\n* brain MRI\n* kidney, testicular\u002Fovarian ultrasound",{"label":13,"type":10,"description":14,"interventionNames":10},"Family members","Family members of Patients will be recruited for:\n\n* completion of medical questionnaire\n* specimen collection (DNA\u002FRNA) from: serum\u002Fplasma\u002Fsaliva\u002Furine\u002Fbuccal swab\u002Fhair follicles\u002Fsperm\u002Fskin biopsy\n* smell testing",[16],{"name":17,"affiliation":18,"role":19},"Nelly Pitteloud, M.D.","Centre Hositalier Universitaire Vaudois (CHUV)","PRINCIPAL_INVESTIGATOR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Emmanuelle Paccou","CONTACT","+41 79 556 60 13","emmanuelle.paccou@chuv.ch",{"name":27,"role":23,"phone":28,"phoneExt":10,"email":29},"Michela Adamo, MD","+41 079 556 85 14","michela.adamo@chuv.ch",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Centre Hospitalier Universitaire Vaudois (CHUV)","RECRUITING","Lausanne","Canton of Vaud","1011","Switzerland","CH",{"type":40,"coordinates":41},"Point",[42,43],6.63282,46.516,{"lat":43,"lon":42},[46,47,48],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},{"name":27,"role":23,"phone":28,"phoneExt":10,"email":29},{"name":17,"role":19,"phone":10,"phoneExt":10,"email":10},{"type":19,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Nelly Pitteloud","Professor of Medicine, Chief of Service",[53],{"name":54,"class":6},"Swiss National Science Foundation","100178744","genetics-of-reproductive-disorders-including-kallmann-syndrome-and-cleft-lip-andor-palate-100178744",false,"NCT01601171","Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and\u002For Palate","The Genetics of Neuroendocrine Reproductive Disorders and of the Cleft Lip and\u002For Palate","Inclusion Criteria:(any of the following conditions)\n\n* hypogonadotropic hypogonadism\n* Kallmann syndrome\n* adult-onset hypogonadotropic hypogonadism\n* hypothalamic amenorrhea\n* polycystic ovarian syndrome\n* primary gonadal failure\n* precocious puberty\n* cleft lip\u002Fpalate\n* family members of the above groups\n\nExclusion Criteria:\n\n* acute illness\u002Fhospitalization\n* pituitary tumors\n* iron overload (hemochromatosis)\n* infiltrative diseases (sarcoidosis)\n* chronic alcohol abuse\n* illicit drug use\n* anabolic steroid abuse",true,"ALL",{"count":65,"type":66},2000,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to explore the genetic basis of reproductive disorders and cleft lip and\u002For palate.",[70,71,72,73,74,75,76,77],"Kallmann Syndrome","Hypogonadotropic Hypogonadism","Hypothalamic Amenorrhea","Polycystic Ovarian Syndrome","Precocious Puberty","Cleft Lip and Palate","Cleft Palate","Cleft Lip",[79,80,81,82,83,84,85,86],"GnRH deficiency","hypogonadism","anosmia","infertility","cleft lip","cleft palate","cryptorchidism","microphallus","2022-06-17",{"date":89,"type":90},"2022-06-21","ACTUAL",{"date":92,"type":10},"2012-03",{"date":94,"type":66},"2030-03",{"name":5,"class":6},1]