[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638168":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":48,"responsibleParty":67,"collaborators":69,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":80,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":44,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":100,"overallStatus":106,"whyStopped":44,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Helse Møre og Romsdal HF","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Genicular nerve block (GNB)","ACTIVE_COMPARATOR","Ultrasound-guided GNB with 5 mL of 5 mg\u002FmL ropivacaine at the superolateral genicular nerve (SLGN), superomedial genicular nerve (SMGN), and the inferomedial genicular nerve (IMGN) with a total volume of 15 mL.",[13],"Procedure: Preoperative genicular nerve block (GNB)",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo nerve block","PLACEBO_COMPARATOR","Ultrasound-guided placebo nerve block using 5 mL of 0.9% normal saline at the superolateral genicular nerve (SLGN), superomedial genicular nerve (SMGN), and the inferomedial genicular nerve (IMGN) with a total volume of 15 mL.",[19],"Procedure: Placebo nerve block",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Preoperative genicular nerve block (GNB)","Participants randomized to the intervention group will receive a preoperative ultrasound-guided genicular nerve block prior to surgery. The procedure is performed under sterile conditions by an experienced anesthesiologist using ultrasound guidance to identify anatomical landmarks.\n\nA local anesthetic (ropivacaine 5 mg\u002FmL) is injected at three sites targeting the sensory innervation of the knee joint: the superolateral, superomedial, and inferomedial genicular nerves. A volume of 5 mL is administered at each site, for a total of 15 mL. If the accompanying genicular artery is not visualized, the injection is performed at the corresponding bony landmark.\n\nThe intervention is administered once before surgery in addition to standard perioperative care, including spinal anesthesia, multimodal analgesia, and local infiltration analgesia during surgery.",[9],[27,28],"GNB","Ultrasound-guided genicular nerve block",{"type":22,"name":15,"description":30,"armGroupLabels":31,"otherNames":32},"Participants randomized to the placebo group will receive a preoperative ultrasound-guided placebo nerve block prior to surgery. The procedure is performed under sterile conditions by an experienced anesthesiologist using ultrasound guidance to identify anatomical landmarks. 5 mL of 0.9% normal saline is injected at three sites targeting the sensory innervation of the knee joint: the superolateral, superomedial, and inferomedial genicular nerves. A volume of 5 mL is administered at each site, for a total of 15 mL. If the accompanying genicular artery is not visualized, the injection is performed at the corresponding bony landmark. The intervention is administered once before surgery in addition to standard perioperative care.",[15],[33],"Saline nerve block",[35],{"name":36,"affiliation":37,"role":38},"Tommy Frøseth Aae, MD, PhD","Department of orthopedic surgery, Nordmøre and Romsdal Hospital, Møre and Romsdal Hospital Trust, Norway","PRINCIPAL_INVESTIGATOR",[40,46],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Myrthle Slettvåg Hoel, Nurse","CONTACT","+47 71120000",null,"myrthle.slettvag.hoel@helse-mr.no",{"name":36,"role":42,"phone":43,"phoneExt":44,"email":47},"tommy.froseth.aae@helse-mr.no",[49],{"facility":50,"status":44,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Nordmøre and Romsdal Hospital (SNR)","Hjelset","Møre og Romsdal","6412","Norway","NO",{"type":57,"coordinates":58},"Point",[59,60],7.49277,62.7805,{"lat":60,"lon":59},[63,66],{"name":64,"role":42,"phone":43,"phoneExt":44,"email":65},"Myrthle Slettvåg Hoel, Studynurse","Myrthle.Slettvag.Hoel@helse-mr.no",{"name":36,"role":42,"phone":43,"phoneExt":44,"email":47},{"type":68,"investigatorFullName":44,"investigatorTitle":44,"investigatorAffiliation":44,"oldNameTitle":44,"oldOrganization":44},"SPONSOR",[70,73,76],{"name":71,"class":72},"The Nordmøre and Romsdal Hospital Trust","UNKNOWN",{"name":74,"class":75},"St. Olavs Hospital","OTHER",{"name":77,"class":75},"Oslo University Hospital","100638168","genicular-nerve-block-in-knee-arthroplasty-100638168",false,"NCT07589127","GENicular Nerve Block in KNEE Arthroplasty","GENicular Nerve Block in KNEE Arthroplasty - The GENKNEE Trial","GENKNEE","Inclusion Criteria:\n\n* Symptomatic knee OA grade II-IV according to the Kellgren-Lawrence classification system scheduled for primary total knee arthroplasty\n* American Society of Anesthesiologists (ASA) Physical Status grade I-III\n* Able to provide written informed consent\n* Able to undergo surgery under spinal anesthesia\n\nExclusion Criteria:\n\n* Younger than 18 or older than 80 years\n* ASA physical status IV\n* Allergy to local anesthetics\n* Revision surgery\n* Chronic opioid use (\\> 3 months)\n* Coagulopathy\n* Cognitive impairment\n* Inability to comply with study procedures\n* Patients scheduled for day care surgery.","ALL","18 Years","80 Years",{"count":90,"type":91},70,"ESTIMATED","INTERVENTIONAL",[94],"NA","The goal of this clinical trial is to learn whether a preoperative genicular nerve block (GNB) can reduce pain after knee replacement surgery in adults with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA). It will also assess whether this treatment can reduce opioid use and improve recovery.\n\nThe main questions it aims to answer are:\n\n* Does a preoperative GNB reduce pain during movement 24 hours after surgery compared with placebo?\n* Does it reduce opioid consumption and improve physical activity and functional outcomes after surgery?\n\nResearchers will compare patients receiving a GNB to patients receiving a placebo injection to see if the nerve block improves postoperative pain and recovery.\n\nParticipants will:\n\n* Be randomly assigned to receive either a GNB or a placebo injection before surgery\n* Undergo standard knee replacement surgery and postoperative care\n* Report pain levels at regular intervals after surgery\n* Complete questionnaires on function, quality of life, and recovery\n* Wear an activity monitor to measure physical activity after surgery\n* Attend follow-up assessments at 1 week, 1 month, and 3 months",[97,98,99],"Osteoarthritis (OA) of the Knee","Total Knee Arthroplasty","Genicular Nerve Block",[101,102,103,104,105],"Osteoarthritis","Knee","Knee osteoarthritis","Total knee arthroplasty","Genicular nerve block","NOT_YET_RECRUITING","2026-05-11",{"date":109,"type":110},"2026-05-15","ACTUAL",{"date":112,"type":91},"2026-06-01",{"date":114,"type":91},"2029-06-01",{"name":5,"class":6},1]