[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582521":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":29,"locations":24,"responsibleParty":35,"collaborators":24,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":41,"acronym":24,"eligibilityCriteria":42,"healthyVolunteers":39,"sex":43,"minAge":24,"maxAge":24,"enrollmentInfo":44,"targetDuration":24,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":53,"overallStatus":57,"whyStopped":24,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":24},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"genicular nerve phenol neurolysis","EXPERIMENTAL","chemical neurolysis using 2 mL of 9% phenol solution prepared from crystallized phenol will be applied to each genicular nerve.",[13],"Procedure: genicular nerve neurolysis",{"label":15,"type":10,"description":16,"interventionNames":17},"genicular nerve radiofrequency ablation","Radiofrequency thermocoagulation will be applied to each nerve at 80 degrees for 90 seconds.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","genicular nerve neurolysis","The superior medial genicular nerve (SMGN), superior lateral genicular nerve (SLGN), and inferior medial genicular nerve (IMGN) will be blocked either by phenol neurolysis or radiofrequency ablation",[9,15],null,[26],{"name":27,"affiliation":5,"role":28},"Ahmed Boeith, MD","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"ahmed boeith, MD","CONTACT","02001003074795","ahmedabdelrahamn2008@med.asu.edu.eg",{"type":36,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100582521","genicular-nerve-phenol-neurolysis-versus-radiofrequency-ablation-for-pain-relief-in-grade-4-knee-osteoarthritis-100582521",false,"NCT06864390","Genicular Nerve Phenol Neurolysis Versus Radiofrequency Ablation for Pain Relief in Grade 4 Knee Osteoarthritis","Inclusion Criteria:\n\n* Grade 4 knee osteoarthritis according to Kellgren-Lawrence radiological classification.\n* Failure to manage pain with conservative methods.\n\nExclusion Criteria:\n\n* Prior knee replacement\n* Patients with cardiac pacemakers or implantable cardiac defibrillators.\n* Septic knee or systemic sepsis.\n* Allergy to any of the drugs used in the study.\n* Coagulopathy or patients on anticoagulants.\n* Patients with psychiatric illness.","ALL",{"count":45,"type":46},114,"ESTIMATED","INTERVENTIONAL",[49],"NA","The goal of this clinical trial is to compare the efficiency and efficacy of genicular nerves blockade by chemical phenol neurolysis versus radiofrequency ablation in managing pain in patients suffering from grade IV KOA in term of NRS pain score.\n\nThe participants will be evaluated by numeric rating scale and oxford knee score for assessment of pain relief up to 16 weeks.",[52],"Joint Pain",[54,55,56],"phenol neurolysis","radiofrequency","Knee osteoarthritis","NOT_YET_RECRUITING","2025-03-06",{"date":60,"type":61},"2025-03-07","ACTUAL",{"date":63,"type":46},"2025-04",{"date":65,"type":46},"2025-11",{"name":5,"class":6}]