[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100575682":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":107,"collaborators":19,"id":109,"slug":110,"hasResults":111,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":111,"sex":117,"minAge":19,"maxAge":118,"enrollmentInfo":119,"targetDuration":19,"studyType":122,"phases":123,"briefSummary":125,"conditions":126,"keywords":130,"overallStatus":32,"whyStopped":19,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":142},{"fullName":5,"class":6},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients","EXPERIMENTAL","The study will be offered consecutively to each patient in whom Kawasaki Disease, Schonlein-Henoch purpura, symptomatic SARS-CoV-2 infection, febrile virosis, and with inflammatory diseases with systemic involvement are diagnosed.",[13],"Other: sample collection",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"sample collection","Blood samples and fecal samples will be taken from patients during evaluation visits. Blood samples will be analyzed for the study of HERVs. While fecal samples will be analyzed for the characterization of gut microbiota.",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Marianna Fabi, MD","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":19,"email":28},"CONTACT","0512143012","marianna.fabi@aosp.bo.it",[30,51,63,77,92],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Ospedale Ramazzini di Carpi, Azienda USL di Modena UO Pediatria","RECRUITING","Carpi","Modena","41012","Italy","IT",{"type":39,"coordinates":40},"Point",[41,42],10.8777,44.78237,{"lat":42,"lon":41},[45,49],{"name":46,"role":26,"phone":47,"phoneExt":19,"email":48},"Elena Corinaldesi","0592025805","elcorinaldesi@yahoo.it",{"name":50,"role":23,"phone":19,"phoneExt":19,"email":19},"Elena Corinaldesi, MD",{"facility":52,"status":32,"city":53,"state":19,"zip":54,"country":36,"countryCode":37,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"IRCCS Azienda Ospedaliero - Universitaria di Bologna, U.O. Pediatria d'Urgenza, Pronto Soccorso e Osservazione Breve ed Intensiva","Bologna","40138",{"type":39,"coordinates":56},[57,58],11.33875,44.49381,{"lat":58,"lon":57},[61,62],{"name":22,"role":26,"phone":27,"phoneExt":19,"email":28},{"name":22,"role":23,"phone":19,"phoneExt":19,"email":19},{"facility":64,"status":32,"city":34,"state":19,"zip":65,"country":36,"countryCode":37,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Azienda Ospedaliera-Universitaria di Modena","41100",{"type":39,"coordinates":67},[68,69],10.92539,44.64783,{"lat":69,"lon":68},[72,76],{"name":73,"role":26,"phone":74,"phoneExt":19,"email":75},"Lorenzo Iughetti, MD","0594222182","iughetti.lorenzo@unimore.it",{"name":73,"role":23,"phone":19,"phoneExt":19,"email":19},{"facility":78,"status":32,"city":79,"state":19,"zip":80,"country":36,"countryCode":37,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"IRCCS Ospedale Pediatrico Bambino Gesù UOC Pediatria Generale","Roma","00165",{"type":39,"coordinates":82},[83,84],11.10642,44.99364,{"lat":84,"lon":83},[87,91],{"name":88,"role":26,"phone":89,"phoneExt":19,"email":90},"Alessandra Marchesi, MD","06 6859 4784","alessandra.marchesi@opbg.net",{"name":88,"role":23,"phone":19,"phoneExt":19,"email":19},{"facility":93,"status":32,"city":94,"state":19,"zip":95,"country":36,"countryCode":37,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Ospedale Regina Margherita, Torino, UO Reumatologia Pediatrica","Torino","10126",{"type":39,"coordinates":97},[98,99],11.99138,44.88856,{"lat":99,"lon":98},[102,106],{"name":103,"role":26,"phone":104,"phoneExt":19,"email":105},"Francesco Licciardi, MD","011 633 1633","francesco.licciardi@cittadellasalute.to.it",{"name":103,"role":23,"phone":19,"phoneExt":19,"email":19},{"type":108,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100575682","genome-analysis-of-human-endogenous-retroviruses-hervscovid19-100575682",false,"NCT06775457","Genome Analysis of Human Endogenous Retroviruses (HERVs)(COVID19)","Genome Analysis of Human Endogenous Retroviruses (HERVs) and Gut Microbiota in Patients With SARS-CoV-2 Infection, Kawasaki Disease and Other Febrile and Inflammatory Diseases With Systemic Involvement in Pediatric Age.","HERV_COVID","Inclusion Criteria:\n\n* Pediatric patients, newly diagnosed with Kawasaki disease\n* Pediatric patients, newly diagnosed with Vasculitis\n* Pediatric patients, newly diagnosed with SARS-CoV-2 infection\n* Pediatric patients, newly diagnosed with febrile virosis\n* Pediatric patients with inflammatory diseases with systemic involvement\n\nExclusion Criteria:\n\n* None","ALL","18 Years",{"count":120,"type":121},120,"ESTIMATED","INTERVENTIONAL",[124],"NA","Human Endogenous Retroviruses (HERVs) are ancient sequences that became integrated into our DNA during evolutionary processes.\n\nThe significance of their presence in DNA is still being studied, but HERVs appear to be involved in the regulation of the immune response.\n\nThe gut microbiota is the set of microorganisms that physiologically colonize the gastrointestinal tract. Progressively increasing attention is being paid to the gut microbiota and its potential role in diseases of various kinds. In particular, it has recently been shown how abnormalities in the microbiota can affect immune regulation by determining the occurrence of certain diseases. One objective of the study is to evaluate whether there is an association between the expression of HERVs and clinical manifestations in pediatric age in patients with various diseases such as Kawasaki Disease, IgA Vasculitis\u002FSchonlein-Henoch's Purpura, SARS-CoV-2 infection, or, finally, febrile virosis.\n\nAnother objective of the study is to evaluate whether there is an association between the presence of particular types of bacteria in the gut microbiota and clinical manifestations in pediatric age in patients with Kawasaki Disease, IgA Vasculitis\u002FSchonlein-Henoch purpura, SARS-CoV-2 infection or febrile virosis.\n\nThe results from this may open new perspectives for both the care and therapeutic management of children with these diseases.",[127,128,129],"SARS CoV-2","Kawasaki Disease","Retrovirus Infection",[131,128,132],"SARS-COV2","Human Endogenous Retroviruses","2025-01-09",{"date":135,"type":136},"2025-01-15","ACTUAL",{"date":138,"type":136},"2021-06-10",{"date":140,"type":121},"2025-12-31",{"name":5,"class":6},5]