[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100420881":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":36,"responsibleParty":52,"collaborators":20,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":20,"maxAge":20,"enrollmentInfo":62,"targetDuration":20,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":38,"whyStopped":20,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"University Hospital Tuebingen","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"WGS Diagnostic","EXPERIMENTAL","Both underage and adult persons (male and female) with diagnostically unsolved rare diseases who have been or are included into diagnostic care at the University Hospital Tübingen, Germany (UKT) and who are suspected of having a genetic cause of the disease.\n\nStudy related procedures: Blood sampling, anamnesis including pedigree, Next Generation Sequencing (NGS) analysis and other omics analysis (transcriptomics, proteomics, metabolomics).",[13],"Genetic: WGS Diagnostic: Blood take for genetic diagnostic",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"GENETIC","WGS Diagnostic: Blood take for genetic diagnostic","Blood sampling, short clinical characterization, WGS based sequencing, NGS analysis and other omics analysis (transcriptomics, proteomics, metabolomics).",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Olaf Rieß, Prof. Dr.","University Hospital Tübingen","STUDY_DIRECTOR",[27,32],{"name":23,"role":28,"phone":29,"phoneExt":30,"email":31},"CONTACT","+49 7071 29","72323","olaf.riess@med.uni-tuebingen.de",{"name":33,"role":28,"phone":29,"phoneExt":34,"email":35},"Andreas Dufke, PD Dr.","72190","andreas.dufke@med.uni-tuebingen.de",[37],{"facility":24,"status":38,"city":39,"state":20,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Tübingen","72076","Germany","DE",{"type":44,"coordinates":45},"Point",[46,47],9.05222,48.52266,{"lat":47,"lon":46},[50,51],{"name":23,"role":28,"phone":29,"phoneExt":30,"email":31},{"name":33,"role":28,"phone":29,"phoneExt":20,"email":35},{"type":53,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100420881","genome-based-management-of-patients-in-precision-medicine-ge-med-towards-a-genomic-health-program-100420881",false,"NCT04760522","Genome-based Management of Patients in Precision Medicine (Ge-Med) Towards a Genomic Health Program","GE-MED","Inclusion Criteria:\n\n* Unclear molecular cause of the disease\n* Suspected genetic cause of the disease\n\nExclusion Criteria:\n\n* Missing informed consent of the patient and if applicable the legal representative\n* Previously performed WES or panel analysis","ALL",{"count":63,"type":64},12000,"ESTIMATED","INTERVENTIONAL",[67],"NA","The GE-MED APPROACH project will enroll patients (n = appr. 12.000) with unclear molecular cause of the disease, suspected genetic cause of the disease without detailed molecular analysis like Whole Exome Sequencing (WES).\n\nThe novelty of this study is to integrate genomic health concepts into immediate clinical care. To achieve these goals, a novel structure for the Triple P (3P) concept of personalized medicine (Personalized, Predictive, Preventive) integrated into a well-established health care system and associated with novel decentralized Disease Analysing Task Forces (DATF) will be implemented.\n\nThe overall goal of this study is to implement, for the first time, Whole Genome Sequencing (WGS) analysis as a first line diagnostic test for all clinical indications such as Rare Disease (RD )and familial cancer syndromes.",[70,71],"Rare Diseases","Genetic Predisposition to Disease",[70,73,74,75,76,77],"Genetic Predisposition","Whole Exome Sequencing (WES)","Whole Genome Sequencing (WGS)","Familial cancer syndromes","Polygenic Risk Scores (PRS)","2023-11-28",{"date":80,"type":81},"2023-11-29","ACTUAL",{"date":83,"type":81},"2021-06-01",{"date":85,"type":64},"2027-07",{"name":5,"class":6},1]