[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544171":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":10,"responsibleParty":28,"collaborators":10,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":36,"acronym":37,"eligibilityCriteria":38,"healthyVolunteers":34,"sex":39,"minAge":40,"maxAge":41,"enrollmentInfo":42,"targetDuration":10,"studyType":45,"phases":10,"briefSummary":46,"conditions":47,"keywords":10,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":10},{"fullName":5,"class":6},"Western Sydney Local Health District","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Kidney Transplant Recipients",null,"Enrolled at time of transplant or post transplant",[13],"Diagnostic Test: Biomarker discovery and validation - with focus on genomic biomarkers",[15],{"type":16,"name":17,"description":17,"armGroupLabels":18,"otherNames":10},"DIAGNOSTIC_TEST","Biomarker discovery and validation - with focus on genomic biomarkers",[9],[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Jennifer SY Li, MBBS, FRACP","CONTACT","612 88905555","jennifer.li@health.nsw.gov.au",{"name":26,"role":22,"phone":23,"phoneExt":10,"email":27},"Philip J O'Connell, MBBS, FRACP","philip.oconnell@sydney.edu.au",{"type":29,"investigatorFullName":30,"investigatorTitle":31,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jennifer Li","Nephrologist and Transplant Physician","100544171","genomic-medicine-in-kidney-transplantation-study-100544171",false,"NCT06365411","GEnomic Medicine in Kidney Transplantation Study","GEM-KiT","Inclusion Criteria: All participants included in the study must be age ≥ 18 years old at time of enrolment and\n\n1. able to provide informed consent (interpreter permitted) for enrolment\n2. consenting to longitudinal follow up (can withdraw post enrolment)\n3. consenting to provide samples for biobanking, including blood, urine, faecal and\u002For kidney biopsy tissue (collected prospectively, separate to routine care)\n\nExclusion Criteria: Patients will be excluded from the study if they are\n\n1. unable (or unwilling) to provide consent, or\n2. have life-expectancy less than 6-months, or\n3. have received a haematopoietic stem cell transplant in the past 5 years.","ALL","18 Years","80 Years",{"count":43,"type":44},1000,"ESTIMATED","OBSERVATIONAL","Investigator led, prospective, observational cohort study to detect genomic features which can predict outcomes following kidney transplantation.\n\n1. Determine non-HLA genomic mismatches between donor-recipient pairs which impact kidney allograft survival following transplantation\n2. Derive polygenic risk scores on pre-transplant blood and\u002For kidney biopsy samples which predict kidney allograft dysfunction\n3. Derive polygenic risk scores on post-transplant blood and\u002For kidney biopsy samples which predict kidney allograft dysfunction",[48,49],"Transplant Complication","Kidney Transplant Rejection","NOT_YET_RECRUITING","2025-03-24",{"date":53,"type":54},"2025-03-28","ACTUAL",{"date":56,"type":44},"2025-06-03",{"date":58,"type":44},"2035-01-01",{"name":5,"class":6}]