[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100455609":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":50,"collaborators":53,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":10,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"University of British Columbia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Case with COVID-19 vaccine adverse event",null,"Patients with GBS, VITT\u002FTTS, or myocarditis\u002Fpericarditis after COVID-19 vaccination",[13],"Biological: COVID-19 vaccines",{"label":15,"type":10,"description":16,"interventionNames":17},"Control without COVID-19 vaccine adverse event","Participants without experiencing GBS, VITT\u002FTTS, or myocarditis\u002Fpericarditis after COVID-19 vaccination",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"BIOLOGICAL","COVID-19 vaccines","Any licensing COVID-19 vaccine platform",[9,15],[25],{"name":26,"affiliation":5,"role":27},"Bruce Carleton, PharmD","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","1.877.878.4131","bcarleton@popi.ubc.ca",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"British Columbia Children's Hospital Research Institute","RECRUITING","Vancouver","British Columbia","V5Z 4H4","Canada","CA",{"type":43,"coordinates":44},"Point",[45,46],-123.11934,49.24966,{"lat":46,"lon":45},[49],{"name":26,"role":30,"phone":10,"phoneExt":10,"email":10},{"type":27,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Bruce Carleton","Director, Pharmaceutical Outcomes Programme, BC Children's Hospital; Division Head, Translational Therapeutics, Department of Pediatrics, University of British Columbia",[54],{"name":55,"class":56},"Centers for Disease Control and Prevention","FED","100455609","genomics-and-covid-19-vaccine-adverse-events-100455609",false,"NCT05212792","Genomics and COVID-19 Vaccine Adverse Events","Genomics of COVID-19 Vaccine-induced Adverse Events (Guillain-Barré Syndrome [GBS], Vaccine-induced Immune Thrombotic Thrombocytopenia [VITT]\u002FThrombosis With Thrombocytopenia Syndrome [TTS], and Myocarditis\u002FPericarditis)","Inclusion Criteria:\n\n* Case: Any patient who received COVID-19 vaccines and developed GBS, VITT\u002FTTS, or myocarditis\u002Fpericarditis after vaccination\n* Control: Any participant who received COVID-19 vaccines and does not experience GBS, VITT\u002FTTS, or myocarditis\u002Fpericarditis.\n\nExclusion Criteria:\n\n* Individuals who have not received a COVID-19 vaccine\n* Individuals who are unable to provide informed consent",true,"ALL","5 Years","99 Years",{"count":69,"type":70},6325,"ESTIMATED","OBSERVATIONAL","Vaccines routinely used are extremely safe; however, severe adverse events to vaccines do occur. As vaccination against COVID-19 has begun, adverse events to the vaccine, particularly Guillain-Barré syndrome (GBS), vaccine-induced immune thrombotic thrombocytopenia (VITT)\u002Fthrombosis with thrombocytopenia syndrome (TTS), and myocarditis\u002Fpericarditis, after COVID-19 vaccination have been reported worldwide.\n\nStudy hypothesis: there are genetic factors that contribute to increased risks of particular COVID-19 vaccine-induced adverse events.\n\nThe objective of the study is to determine if there are specific genetic factors strongly associated with each of the COVID-19 vaccine-induced adverse events (i.e., GBS, VITT\u002FTTS, and myocarditis\u002Fpericarditis).",[74],"Vaccine Adverse Reaction",[76,77,78,79,80,81,82],"Genomics","COVID-19 vaccine adverse event","Guillain-Barré syndrome (GBS)","Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT)","Thrombosis with thrombocytopenia syndrome (TTS)","Myocarditis","Pericarditis","2026-04-27",{"date":85,"type":86},"2026-05-01","ACTUAL",{"date":88,"type":86},"2022-06-24",{"date":90,"type":70},"2026-12",{"name":5,"class":6},1]