[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100562528":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":42,"responsibleParty":61,"collaborators":63,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":10,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":10,"maxAge":10,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Hospital de Clinicas de Porto Alegre","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"RPL group",null,"The RPL group will include women with a history of at least two spontaneous pregnancy losses, regardless of whether they have living children, and whose etiology for the pregnancy losses was not determined by the care team's protocols.",[13,14],"Diagnostic Test: Exome test","Diagnostic Test: Microbiota analysis",{"label":16,"type":10,"description":17,"interventionNames":18},"Control group","Women with at least two full-term pregnancies and no history of difficulty getting pregnant, pregnancy loss or other infertility factors will be enrolled in the control group.",[14],[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"DIAGNOSTIC_TEST","Exome test","An exome will be performed on the participants of RPL group.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Microbiota analysis","A cervical microbiota analysis will be performed in the RPL and control groups.",[16,9],[30],{"name":31,"affiliation":32,"role":33},"Lucas Rosa Fraga, PhD, Professor","Hospital de Clínicas de Porto Alegre","PRINCIPAL_INVESTIGATOR",[35,39],{"name":31,"role":36,"phone":37,"phoneExt":10,"email":38},"CONTACT","+555133597661","lrfraga@hcpa.edu.br",{"name":40,"role":36,"phone":37,"phoneExt":10,"email":41},"Luiza Pretto, PhD Student","luizapretto@hcpa.edu.br",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Hospital de Clínicas de Porto Alegre (HCPA)","RECRUITING","Porto Alegre","Rio Grande do Sul","90410-000","Brazil","BR",{"type":52,"coordinates":53},"Point",[54,55],-51.23019,-30.03283,{"lat":55,"lon":54},[58,59,60],{"name":31,"role":36,"phone":37,"phoneExt":10,"email":38},{"name":40,"role":36,"phone":37,"phoneExt":10,"email":41},{"name":31,"role":36,"phone":10,"phoneExt":10,"email":10},{"type":62,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[64],{"name":65,"class":6},"Federal University of Rio Grande do Sul","100562528","genomics-and-microbiome-investigation-in-cases-of-recurrent-pregnancy-losses-100562528",false,"NCT06604338","Genomics and Microbiome Investigation in Cases of Recurrent Pregnancy Losses","Evaluation of Predisposing Factors for Idiopathic Recurrent Pregnancy Losses: a Study Using a Genomic and Microbiota Approach","Inclusion Criteria:\n\n* RPL group: history of at least two spontaneous pregnancy losses, regardless of whether they have living children, and whose etiology for the pregnancy losses was not determined by the care team\\'s protocols;\n* Control group: at least two full-term pregnancies and no history of difficulty getting pregnant, pregnancy loss or other infertility factors.\n\nExclusion Criteria:\n\n* RPL group: less than two spontaneous pregnancy losses and those with a known cause for repeated pregnancy losses;\n* Control group: N\u002FA","FEMALE",{"count":75,"type":76},20,"ESTIMATED","OBSERVATIONAL","Recurrent pregnancy losses (RPL) are characterized by the occurrence of more than one spontaneous pregnancy loss. It is caused by different known factors, but about half of the cases remain without an explanation. Efforts are being done in the scientific community to solve this cases. In this study, the investigators aim to investigate genetic factors that might predispose to RPL, as well as the influence of the uterine microbiota (microorganisms that normally live in the uterus of women).",[80],"Recurrent Pregnancy Loss(RPL)",[82,83,84,85,86,87],"Miscarriage","Recurrent miscarriage","Abortion","Recurrent abortion","Genetic susceptibility","Microbiome","2024-09-17",{"date":90,"type":91},"2024-09-19","ACTUAL",{"date":93,"type":91},"2023-04-14",{"date":95,"type":76},"2025-12",{"name":5,"class":6},1]