[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100517024":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":23,"responsibleParty":43,"collaborators":7,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":7,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":7,"enrollmentInfo":54,"targetDuration":7,"studyType":57,"phases":7,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":66,"whyStopped":7,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Heinrich-Heine University, Duesseldorf","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Malte Kelm, Prof.","Clinic for Cardiology, Pneumology and Angiology at University Hospital Düsseldorf","STUDY_CHAIR",[14,19],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Daniel Oehler, MD","CONTACT","+492118118800","Daniel.oehler@med.uni-duesseldorf.de",{"name":20,"role":16,"phone":21,"phoneExt":7,"email":22},"Lisa Dannenberg, MD","+49211811800","lisa.dannenberg@med.uni-duesseldorf.de",[24],{"facility":25,"status":7,"city":26,"state":7,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"University-Hospital Düsseldorf Division of Cardiology, Pulmonary Disease and Vascular Medicine","Düsseldorf","40225","Germany","DE",{"type":31,"coordinates":32},"Point",[33,34],6.77927,51.22319,{"lat":34,"lon":33},[37,41],{"name":38,"role":16,"phone":39,"phoneExt":7,"email":40},"Clinical Trial Unit","+492118105315","ctu@med.uni-duesseldorf.de",{"name":15,"role":42,"phone":7,"phoneExt":7,"email":7},"PRINCIPAL_INVESTIGATOR",{"type":44,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100517024","genomics-in-heart-transplants-100517024",false,"NCT06012162","Genomics in Heart Transplants","Long-read Genome Sequencing and Risk Stratification of Myocardial Ischemia in Patients With Heart Transplantation","Inclusion Criteria:\n\n* Patients \\> 18 years old undergoing heart transplantation in our centre\n\nExclusion Criteria:\n\n* \\\u003C 18 years\n* incapable of giving consent","ALL","18 Years",{"count":55,"type":56},200,"ESTIMATED","OBSERVATIONAL","A cross-sectional analysis of 200 heart transplant recipients, combining in-depth phenotyping and risk factor assessment (cardiac MRI, coronary angiogram with OCT, cardiorespiratory exercise tests, exogenic factors like nutrition, smoking, lipid profile) with short-read whole-genome sequencing to elucidate the interplay of established PRS from the literature and exogenic risk factors with respect to HTx outcomes will be carried out.\n\nBesides that, a long-read whole-genome sequencing of 100 newly transplanted recipients and their corresponding donors and extend latest bioinformatics methods developed by the study to analyze long-read data will be performed. This will enable a comprehensive and integrated analysis of structural variants, polygenic risk, high-penetrance variant genotypes, immunogenetic (major and minor histocompatibility), and individual lifestyle risk factors in a unique donor-recipient cohort, elucidating the extent of within-cohort variability and cross-correlations between the considered potential risk factors and an exploratory analysis of the utility of genetic risk scores in light of the study results will be carried out.",[60],"Heart Transplantation",[62,63,64,65],"heart transplantation","long-read genomics","risk stratification","myocardial ischemia","NOT_YET_RECRUITING","2023-08-21",{"date":69,"type":70},"2023-08-25","ACTUAL",{"date":72,"type":56},"2024-01",{"date":74,"type":56},"2028-01",{"name":5,"class":6},1]