[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588184":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":14,"responsibleParty":45,"collaborators":7,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":7,"enrollmentInfo":57,"targetDuration":7,"studyType":60,"phases":7,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":17,"whyStopped":7,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta","OTHER",null,[9],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Anna Bersano, MD","CONTACT","+ 39 02.2394","anna.bersano@istituto-besta.it",[15,29],{"facility":16,"status":17,"city":18,"state":7,"zip":7,"country":19,"countryCode":20,"cosmosGeoPoint":21,"geoPoint":26,"contacts":27},"Fondazione IRCCS Istituto Neurologico Carlo Besta","RECRUITING","Milan","Italy","IT",{"type":22,"coordinates":23},"Point",[24,25],12.59836,42.78235,{"lat":25,"lon":24},[28],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},{"facility":30,"status":31,"city":32,"state":7,"zip":7,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":39,"contacts":40},"Hospital Universitario de la Princesa, Madrid","NOT_YET_RECRUITING","Madrid","Spain","ES",{"type":22,"coordinates":36},[37,38],-3.70256,40.4165,{"lat":38,"lon":37},[41],{"name":42,"role":11,"phone":43,"phoneExt":7,"email":44},"Alicia Gonzales Martinez","91 520 22 89","alicia.gonzalez.martinez@live.com",{"type":46,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100588184","genotype-clinical-features-and-imaging-of-neuroradiological-abnormalities-in-cadasil-100588184",false,"NCT06938100","Genotype, Clinical Features and Imaging of Neuroradiological Abnormalities in CADASIL","GENICa","Inclusion criteria:\n\n* patients of either sex older than 18 years of age;\n* finding of a pathogenic mutation on genetic analysis of NOTCH3;\n* in the absence of unambiguous mutation, presence of characteristic deposits (GOM) within small vessels at skin biopsy\n\nExclusion criteria:\n\n* do not meet the diagnostic criteria of CADASIL;\n* are unable to give consent for the study due to aphasic or cognitive impairment or because they are deceased at the time of enrollment and their next of kin refuse to give consent for study participation.",true,"ALL","18 Years",{"count":58,"type":59},100,"ESTIMATED","OBSERVATIONAL","The project aims to retrospectively and prospectively analyze a population of CADASIL patients in order to study the natural history of the disease by correlating the symptom spectrum with genetic risk and specific neuroradiological and biological markers\n\n\\- Stratifying patients according to their disease risk, this could contribute to the discovery of personalized therapeutic targets.",[63,64],"CADASIL","CADASIL (Diagnosis)",[63,66],"NOTCH3","2025-04-14",{"date":69,"type":70},"2025-04-22","ACTUAL",{"date":72,"type":70},"2023-11-21",{"date":74,"type":59},"2027-10-31",{"name":5,"class":6},2]