[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100435254":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":7,"locations":8,"responsibleParty":27,"collaborators":7,"id":29,"slug":30,"hasResults":31,"nctId":32,"briefTitle":33,"officialTitle":34,"acronym":7,"eligibilityCriteria":35,"healthyVolunteers":31,"sex":36,"minAge":7,"maxAge":7,"enrollmentInfo":37,"targetDuration":7,"studyType":40,"phases":7,"briefSummary":41,"conditions":42,"keywords":7,"overallStatus":11,"whyStopped":7,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":53},{"fullName":5,"class":6},"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","OTHER",null,[9],{"facility":10,"status":11,"city":12,"state":7,"zip":7,"country":13,"countryCode":14,"cosmosGeoPoint":15,"geoPoint":20,"contacts":21},"China Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.","RECRUITING","Shanghai","China","CN",{"type":16,"coordinates":17},"Point",[18,19],121.45806,31.22222,{"lat":19,"lon":18},[22],{"name":23,"role":24,"phone":25,"phoneExt":7,"email":26},"Gengru Jiang","CONTACT","+86-13917983703","jianggeng-ru@hotmail.com",{"type":28,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100435254","genotype-phenotype-correlations-in-patients-with-alport-syndrome-100435254",false,"NCT04947813","Genotype-Phenotype Correlations in Patients With Alport Syndrome","Association Analysis Between Variants of COL4A3\u002FCOL4A4\u002FCOL4A5 and Alport Syndrome in the Han Chinese Population","Inclusion Criteria:\n\n1. Age: up to 99 Years (Child, Adult, Older Adult)\n2. Sex: All;\n3. Families and patients with a history of renal hematuria;\n4. Those who signed the informed consent.\n\nExclusion Criteria:\n\n1. Polycystic kidney disease, hypertensive nephropathy, etc.;\n2. Kidney biopsy is diagnosed as other primary\u002Fsecondary kidney disease without type IV collagen-related kidney disease, including IgA nephropathy, membranous nephropathy, lupus nephritis, etc.\n3. Incomplete medical history or clinical data.","ALL",{"count":38,"type":39},8165,"ESTIMATED","OBSERVATIONAL","Alport syndrome (AS) is caused by pathogenic variants in the type IV collagen genes COL4A3, COL4A4, and COL4A5. This study aims to enroll families and patients with a history of renal hematuria in 27 hospitals and detect these three genes for AS screening. This study also aims to analysis the effect of COL4A3\u002FCOL4A4\u002FCOL4A5 genotype on the development of kidney disease.",[43],"Alport Syndrome","2021-06-24",{"date":46,"type":47},"2021-07-01","ACTUAL",{"date":49,"type":47},"2021-01-01",{"date":51,"type":39},"2030-12-31",{"name":5,"class":6},1]