[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100554341":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":35,"responsibleParty":52,"collaborators":55,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":20,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":20,"enrollmentInfo":68,"targetDuration":20,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":37,"whyStopped":20,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University Hospital, Motol","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"patients with MVK deficiency","EXPERIMENTAL","patients fulfilling inclusion criteria",[13],"Dietary Supplement: geranylgeraniol",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIETARY_SUPPLEMENT","geranylgeraniol","GG Pure (Extendlife Natural Products) containing GG gold®30 Annatto Extract, 500 mg capsule, use for 3 months, once daily",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Anna Šedivá, Mgr","PRINCIPAL_INVESTIGATOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Anna Šedivá, Prof","CONTACT","+420603166112","anna.sediva@fnmotol.cz",{"name":32,"role":28,"phone":33,"phoneExt":20,"email":34},"Eva Aljamal, Mgr","+420601354311","eva.aljamal@fnmotol.cz",[36],{"facility":5,"status":37,"city":38,"state":20,"zip":39,"country":40,"countryCode":20,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Prague","15006","Czechia",{"type":42,"coordinates":43},"Point",[44,45],14.42076,50.08804,{"lat":45,"lon":44},[48,50],{"name":27,"role":28,"phone":49,"phoneExt":20,"email":30},"+420 603166112",{"name":32,"role":28,"phone":51,"phoneExt":20,"email":34},"+420 601354311",{"type":24,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Anna Sediva","Prof. Anna Sediva, MD, PhD",[56],{"name":57,"class":6},"Washington University School of Medicine","100554341","geranylgeraniol-supplementation-in-patients-with-mevalonate-kinase-deficiency-100554341",false,"NCT06497829","Geranylgeraniol Supplementation in Patients With Mevalonate Kinase Deficiency","Geranylgeraniol Supplementation in Patients With Mevalonate Kinase Deficiency, MVK Deficiency (hyperIgD Syndrome)","Inclusion Criteria:\n\n* Patients older than 12 years with genetically confirmed MVK deficiency\n* Overall good clinical status apart from the clinical presentation of the MVK deficiency\n* Normal liver tests\n* Compliance with the study protocol\n\nExclusion Criteria:\n\n• Children below 12 years",true,"ALL","12 Years",{"count":69,"type":70},6,"ESTIMATED","INTERVENTIONAL",[73],"NA","Mevalonate kinase deficiency (HyperIgD syndrome, HIDS) is an inborn error of immunity caused by a block in the mevalonate pathway. The subsequent lack of isoprenoids with antiinflammatory properties might contribute to the autoinflammatory nature of the disease.\n\nA pilot study aims to verify the safety and efficacy of the dietary supplement Geranylgeraniol, aiming at a mitigation of isoprenoids deficiency caused by the above-mentioned block in the MVK pathway.",[76],"Mevalonate Kinase Deficiency",[78,79,80,17],"immunoglobulin D","mevalonate kinase","isoprenoids","2024-07-09",{"date":83,"type":84},"2024-07-12","ACTUAL",{"date":86,"type":84},"2022-01-25",{"date":88,"type":70},"2025-12-31",{"name":5,"class":6},1]