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Schulz, MD, Head of the Department of Neurology at the University Hospital Aachen and Project Manager",[263,266,269],{"name":264,"class":265},"Eisai GmbH","INDUSTRY",{"name":267,"class":268},"Lilly Deutschland GmbH Germany","UNKNOWN",{"name":270,"class":265},"Biogen","100626236","german-dementia-registry-100626236",false,"NCT07433010","German Dementia Registry","DemReg","Inclusion Criteria:\n\nInclusion Criteria for Patient:\n\n* Ability of the participant and\u002For his\u002Fher legally authorized representative (e.g., spouse or legal guardian), as appropriate and applicable, to understand the purpose and risks of the register and provide signed and dated informed consent and authorization to use protected health information (PHI) in accordance with national and local privacy regulations.\n* Participating patients must have a diagnosis of SCD, MCI or early dementia of different etiology (i.e. Alzheimer's Disease, Frontotemporal Dementia, Parkinson's Disease, Lewy-Body Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Normal Pressure Hydrocephalus, Major Depression; Vascular Dementia; TDP-43 associated limbic encephalopathy (LATE), Mixed Dementia AD + VaD, Prion-Associated Dementia) together with biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42\u002Famyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging.\n* At least 18 years of age.\n\nInclusion Criteria for family member:\n\n* At least 18 years of age.\n* Patient was included in the registry\n* Family member is strongly involved to the patient's life according to the patient's statement\n* Ability of the participant, as appropriate and applicable, to understand the purpose and risks of the register\n\nExclusion Criteria:\n\nExclusion Criteria for Patient:\n\n* Unwilling to provide informed consent.\n* No available biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42\u002Famyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging.\n\nExclusion Criteria for family member:\n\n* Unable or unwilling to provide informed consent.","ALL","18 Years",{"count":281,"type":282},5000,"ESTIMATED","20 Years","OBSERVATIONAL","The German Dementia Registry (DEMREG) is a large-scale national prospective biomarker-based study for cognitive impairment and dementia, providing an integrated clinical research platform for research studies.",[287],"Dementia Disorder",[289,290,291,292,293,294,295],"Dementia","Registry","Biomarkers","Neurodegeneration","Natural history","Treatment","Mild Cognitive Impairment","2026-02-18",{"date":298,"type":299},"2026-02-25","ACTUAL",{"date":301,"type":299},"2022-05-16",{"date":303,"type":282},"2099-12",{"name":5,"class":6},24]