[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100533150":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":24,"locations":31,"responsibleParty":50,"collaborators":52,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Liverpool John Moores University","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Postmenopausal + Hot Flush (P+HF)",null,"Postmenopausal women who regularly experience hot flushes.",{"label":13,"type":10,"description":14,"interventionNames":10},"Postmenopausal + Hot Flush (P-HF)","Postmenopausal women who do not experience hot flushes.",{"label":16,"type":10,"description":17,"interventionNames":10},"Premenopausal","Premenopausal women who experience regular menstruation.",[19,22],{"name":20,"affiliation":5,"role":21},"Kirsty A. Roberts, PhD","PRINCIPAL_INVESTIGATOR",{"name":23,"affiliation":5,"role":21},"David A Low, PhD",[25,29],{"name":20,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","0151 904 6244","k.a.roberts@ljmu.ac.uk",{"name":23,"role":26,"phone":27,"phoneExt":10,"email":30},"d.a.low@ljmu.ac.uk",[32],{"facility":5,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Liverpool","Merseyside","L3 3AF","United Kingdom","UK",{"type":40,"coordinates":41},"Point",[42,43],-2.97794,53.41058,{"lat":43,"lon":42},[46,48],{"name":20,"role":26,"phone":47,"phoneExt":10,"email":28},"07780876255",{"name":23,"role":26,"phone":49,"phoneExt":10,"email":30},"01519046244",{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[53],{"name":54,"class":6},"British Heart Foundation","100533150","getting-under-the-skin-of-the-menopausal-hot-flush-100533150",false,"NCT06222073","Getting Under the Skin of the Menopausal Hot Flush","The Menopausal Hot Flush: Cutaneous Vascular and Sudomotor Function and Structure in Symptomatic Women","Inclusion Criteria:\n\n* Aged \\>45 years for the postmenopausal cohort and aged 18-30 years for the premenopausal cohort\n* Female\n* Amenorrhoeic for \\>6 months (postmenopausal criteria)\n* \\>4 hot flushes per day (symptomatic postmenopausal criteria)\n* Eumenorrhoeic with regular menstrual cycles (premenopausal criteria)\n* Healthy\n* Non-smoker\n* BMI 18-30 kg\u002Fm2\n* No history of cardiovascular or respiratory disease\n* No history of metabolic disease e.g. type II diabetes\n* Drink \\\u003C14 units of alcohol per week\n* Not taking any medication or treatments to alleviate hot flushes\n\nExclusion Criteria:\n\n* Aged \\\u003C 18 years or 31-44 years\n* Male\n* Smokers\n* Medical history of cardiovascular\u002Frespiratory disease\n* Medical history of metabolic disease e.g. type II diabetes\n* Drink \\>15 units of alcohol per week\n* On medication or treatments to alleviate hot flushes or have taken such medication\u002Ftreatment within the previous 6 months\n* BMI of \\\u003C18 or \\>30 kg\u002Fm2\n* Vaccination (\\\u003C1 week) due to induced systemic inflammatory reaction\n* Local forearm infection\n* Allergy to local anaesthetic\u002FMarcain\u002Famide-group anaesthetics\n* Pregnant",true,"FEMALE","18 Years","60 Years",{"count":67,"type":68},36,"ESTIMATED","OBSERVATIONAL","The aim of this research is to 1) test how the skin blood vessels and sweat glands function in women who experience hot flushes by using skin microdialysis to deliver small amounts of substances to the skin that cause increased skin blood flow and sweating, and 2) examine the structure of the skin blood vessels and sweat glands in the skin of women who experience hot flushes by taking a very small skin biopsy. Any changes in the function or structure of the skin blood vessels or sweat glands in women with hot flushes would increase our understanding of what causes hot flushes and help to design effective treatments.",[72],"Menopause",[74,75,76,77,78,79],"hot flush","skin","blood flow","sweating","structure","function","2025-03-13",{"date":82,"type":83},"2025-03-18","ACTUAL",{"date":85,"type":83},"2023-01-01",{"date":87,"type":68},"2025-12-31",{"name":5,"class":6},1]