[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605081":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":10,"responsibleParty":26,"collaborators":10,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":35,"acronym":36,"eligibilityCriteria":37,"healthyVolunteers":32,"sex":38,"minAge":39,"maxAge":40,"enrollmentInfo":41,"targetDuration":44,"studyType":45,"phases":10,"briefSummary":46,"conditions":47,"keywords":50,"overallStatus":55,"whyStopped":10,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":63,"locationsCount":10},{"fullName":5,"class":6},"Minia University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"control group",null,"periodontally healthy participants",{"label":13,"type":10,"description":14,"interventionNames":10},"study group","periodontitis stage 3 and 4",[16],{"name":17,"affiliation":18,"role":19},"shaimaa Hamdy, lecturer","lecturer of periodontology Nahda University","STUDY_CHAIR",[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"shaimaa Hamdy, lecturer of Periodontology","CONTACT","+201030576405","shimaa.3m.sh@gmail.com",{"type":27,"investigatorFullName":28,"investigatorTitle":29,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","shaimaa hamdy","lecturer of periodontology","100605081","gingival-crevicular-fluid-oxidized-low-density-lipoprotein-levels-in-health-and-stage-iiiiv-periodontitis-100605081",false,"NCT07157878","Gingival Crevicular Fluid Oxidized Low-Density Lipoprotein Levels in Health and Stage III\u002FIV Periodontitis","Gingival Crevicular Fluid Oxidized Low-Density Lipoprotein Levels in Health and Stage III\u002FIV Periodontitis: A Cross-Sectional Comparative Study","LDL in GCF","Inclusion Criteria:\n\n* For all participants (applies to both groups):\n\n  1. Age 30-60 years.\n  2. Systemically healthy (based on medical history and physician clearance, if needed).\n  3. No history of periodontal treatment within the last 6 months.\n\nExclusion Criteria:\n\n* 1\\. History of systemic diseases affecting periodontium (e.g., uncontrolled diabetes, autoimmune diseases, osteoporosis).\n\n  2\\. Current or past diagnosis of Alzheimer's disease or other neurodegenerative disorders.\n\n  3\\. Use of medications affecting periodontal status (e.g., immunosuppressants, long-term corticosteroids, anticonvulsants).\n\n  4\\. Antibiotic or anti-inflammatory therapy within the past 3 months. 5. Current smokers or history of smoking in the past year.","ALL","30 Years","65 Years",{"count":42,"type":43},40,"ESTIMATED","2 Days","OBSERVATIONAL","Periodontitis is a chronic, multifactorial inflammatory disease primarily caused by dysbiotic plaque biofilms, characterized by the progressive destruction of the supporting structures of the teeth. In advanced stages (Stage III\u002FIV), periodontitis leads to significant attachment and bone loss, often culminating in tooth loss and a negative impact on the patient's quality of life. Recent evidence has emphasized the systemic implications of periodontal inflammation, suggesting a bidirectional relationship between periodontitis and various systemic conditions, especially cardiovascular diseases",[48,49],"Periodontal Diseases","LDL Hyperlipoproteinemia",[51,52,53,54],"Periodontitis","LDL","GCF","periodontal health","NOT_YET_RECRUITING","2025-09-02",{"date":58,"type":59},"2025-09-05","ACTUAL",{"date":61,"type":43},"2025-09-15",{"date":61,"type":43},{"name":28,"class":6}]