[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622998":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":30,"responsibleParty":59,"collaborators":63,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":10,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":10,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":10,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Easy CPB Separation",null,"Easy separation from CPB was defined as no pharmacologic support or use of a single agent (either vasoactive or inotropic).",[13],"Diagnostic Test: Myocardial strain imaging",{"label":15,"type":10,"description":16,"interventionNames":17},"Difficult CPB Separation","Difficult CPB separation can be defined as the need of at least 2 inotropes or vasopressors to successfully accomplish the separation from CPB.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Myocardial strain imaging","Two-dimensional strain analysis was performed using frame-by-frame tracking of unique patterns of bright and dark pixels in grayscale (B-mode) sector images to assess myocardial deformation. The frame rate was maintained between 40 and 90 Hz. The myocardium in each image was divided into six myocardial segments, which were individually assessed for tracking quality. GLS was calculated as the average strain value of 18 myocardial segments obtained from the three echocardiographic views. Patients were included in the final analysis if at least 15 out of 18 segments were considered acceptable for strain measurement by the investigator.",[15,9],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Mustafa E Gurcu, MD","CONTACT","+905058917800","emregurcu@gmail.com",[31,48],{"facility":32,"status":33,"city":34,"state":10,"zip":10,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"University of Rome Tor Vergata","RECRUITING","Rome","Italy","IT",{"type":38,"coordinates":39},"Point",[40,41],12.51133,41.89193,{"lat":41,"lon":40},[44],{"name":45,"role":27,"phone":46,"phoneExt":10,"email":47},"Valentina Ajello","+39 06 7259 3099","rettore@uniroma2.it",{"facility":5,"status":33,"city":49,"state":10,"zip":10,"country":50,"countryCode":10,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Istanbul","Turkey (Türkiye)",{"type":38,"coordinates":52},[53,54],28.94966,41.01384,{"lat":54,"lon":53},[57],{"name":58,"role":27,"phone":28,"phoneExt":10,"email":29},"Mustafa E Gurcu",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","mustafa emre gürcü","Attending Medical Doctor",[64,66],{"name":32,"class":65},"OTHER",{"name":67,"class":65},"San Raffaele University Hospital, Italy","100622998","gls-in-difficult-cpb-weaning-100622998",false,"NCT07390903","GLS in Difficult CPB Weaning","Global Longitudinal Strain as a Predictor of Difficult Separating From Cardiopulmonary Bypass","Inclusion Criteria\n\n* Age \\> 18 years.\n* Scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB).\n* Provided written informed consent to participate.\n* Eligible surgical procedures include:\n\n  * Isolated mitral valve replacement or repair.\n  * Isolated aortic valve replacement or repair.\n  * Isolated coronary artery bypass grafting (CABG).\n  * Combined valve and CABG surgery.\n  * Multiple valve replacement or repair.\n  * Surgery involving the ascending aorta or aortic arch.\n\nExclusion Criteria\n\n* Emergency cardiac surgery.\n* Redo cardiac surgery.\n* Contraindications to transesophageal echocardiography (TEE).\n* Critical preoperative conditions, including:\n\n  * Ongoing inotropic drug therapy.\n  * Preoperative mechanical circulatory support (e.g., IABP, ECMO, VAD).\n  * Requirement for mechanical ventilation.\n  * Preoperative atrial fibrillation.","ALL","18 Years",{"count":78,"type":79},213,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn whether global longitudinal strain (GLS), measured by echocardiography, can predict difficulty separating from cardiopulmonary bypass (CPB) in adults undergoing elective cardiac surgery.\n\nThe main questions it aims to answer are:\n\n* Can preoperative GLS measurement predict difficult separation from CPB?\n* Are GLS values associated with outcomes such as intensive care unit (ICU) stay, hospital stay, cardiac biomarkers, or 30-day mortality?\n\nParticipants will:\n\n* Undergo standard cardiac surgery requiring CPB\n* Have echocardiographic assessments (TTE before and after surgery)\n* Have their recovery and outcomes monitored, including ICU and hospital stay, postoperative labs, and survival within 30 days",[83,84,85,86,87,88],"Cardiopulmonary Bypass","Coronary Artery Bypass","Heart Valve Diseases","Echocardiography","Intraoperative Complications","Postoperative Complications (Cardiopulmonary)","2026-02-01",{"date":91,"type":92},"2026-02-05","ACTUAL",{"date":91,"type":79},{"date":95,"type":79},"2026-08-30",{"name":5,"class":6},2]