[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590808":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":7,"responsibleParty":19,"collaborators":7,"id":21,"slug":22,"hasResults":23,"nctId":24,"briefTitle":25,"officialTitle":26,"acronym":27,"eligibilityCriteria":28,"healthyVolunteers":23,"sex":29,"minAge":30,"maxAge":7,"enrollmentInfo":31,"targetDuration":7,"studyType":34,"phases":7,"briefSummary":35,"conditions":36,"keywords":39,"overallStatus":44,"whyStopped":7,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":7},{"fullName":5,"class":6},"Manchester University NHS Foundation Trust","OTHER_GOV",null,[9],{"name":10,"affiliation":11,"role":12},"Hood M Thabit","Manchester Royal Infirmary","PRINCIPAL_INVESTIGATOR",[14],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Hood Thabit, MD PhD","CONTACT","00441612766703","hood.thabit@mft.nhs.uk",{"type":20,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100590808","glucose-levels-in-acute-pancreatitis-and-the-impact-of-insulin-depletion-and-bacterial-endotoxaemia-100590808",false,"NCT06972238","Glucose Levels in Acute Pancreatitis and the Impact of Insulin Depletion and Bacterial Endotoxaemia","A Prospective Observational Study of Acute Pancreatitis Severity and the Association of Glucose Time in Range and Stress Hyperglycaemia, Plasma Insulin Depletion and Bacterial Endotoxaemia","GLIDE","Inclusion Criteria:\n\n1. Age 18 years or over\n2. Admission diagnosis of acute pancreatitis (based on Revised Atlanta Criteria)\n3. Ability to provide informed consent in English\n\nExclusion Criteria:\n\n1. Known diabetes mellitus\n2. Use of insulin therapy before admission\n3. Pregnancy\n4. Contraindications to CGM (e.g., allergy to device adhesive)","ALL","18 Years",{"count":32,"type":33},30,"ESTIMATED","OBSERVATIONAL","There are currently no early predictive biomarkers for severity of acute pancreatitis (AP) that would allow stratification of patients for potential early interventional therapies. Hyperglycaemia is frequently observed to accompany and contribute to severe AP. However, the underlying mechanism is multifactorial, including in the acute phase of injury, where elevated adrenaline, cortisol and glucagon and inflammatory cytokine-induced insulin resistance all contribute to hyperglycaemia. The investigators propose that the extent of collateral injury of pancreatic β-cells and consequent loss of insulin secretion during the course of acute pancreatitis (AP) underlies disease severity. The investigators will measure plasma C-peptide (as a reliable readout of endogenous insulin), with moment-to-moment glucose monitoring (using subcutaneous continuous glucose monitoring devices), and bacterial endotoxin (lipopolysaccharide (LPS) in a prospective cohort of 30 severe AP patient blood samples taken every 5 days for up to 5 weeks of hospitalization.",[37,38],"Pancreatitis, Acute","Hyperglycaemia",[40,38,41,42,43],"Pancreatitis","inflammation","clinical severity","beta-cell","NOT_YET_RECRUITING","2025-05-16",{"date":47,"type":48},"2025-05-21","ACTUAL",{"date":50,"type":33},"2025-12-01",{"date":52,"type":33},"2026-08-30",{"name":5,"class":6}]