[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100498838":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":31,"responsibleParty":49,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":10,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":10,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"IRCCS San Raffaele","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Adult neurosurgical patients",null,"Adult neurosurgical patients with a brain lesion suspected for GBM, candidate to gross total tumor resection (GTR), followed by radiotherapy and chemotherapy (concomitant and adjuvant).",[13],"Diagnostic Test: Blood, CSF and tumor samples",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Blood, CSF and tumor samples","Blood, CSF and brain tissue sampling of Glu and Glu regulatory proteins.",[9],[21],{"name":22,"affiliation":5,"role":23},"Pietro Mortini, MD, Prof.","STUDY_DIRECTOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":29,"email":30},"Sincinelli Laura","CONTACT","0226436658","0039","sincinelli.laura@hsr.it",[32],{"facility":33,"status":34,"city":35,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"IRCCS San Raffaele Scientific Institute","RECRUITING","Milan","20132","Italy","IT",{"type":40,"coordinates":41},"Point",[42,43],9.18951,45.46427,{"lat":43,"lon":42},[46],{"name":47,"role":27,"phone":48,"phoneExt":10,"email":30},"Laura Sincinelli","003926435568",{"type":50,"investigatorFullName":22,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Head of department","100498838","glutamate-excitotoxicity-and-its-role-in-glioblastoma-biology-100498838",false,"NCT05775458","Glutamate Excitotoxicity and Its Role in Glioblastoma Biology","Role of Glutamate-mediate Excitotoxicity in Invasion and Progression Processes of Glioblastoma Multiforme","Inclusion Criteria:\n\n* Adult patients with a brain lesion suspected for GBM, candidate to gross total tumor resection (GTR), followed by radiotherapy and chemotherapy (concomitant and adjuvant).\n* Patient able to provide informed consent.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Liver disease\n* Severe anemia (Hb \\\u003C8mg\u002Fdl)\n* Pregnancy","ALL","18 Years",{"count":62,"type":63},50,"ESTIMATED","OBSERVATIONAL","Gliomas are the most frequent type of primary brain tumors in adults; among them glioblastoma multiforme (GBM) is the most malignant, being associated with the worst prognosis. Glutamate (Glu) is an aminoacid, responsible for essential functions in the Central Nervous System (CNS), acting both as metabolite and neurotransmitter. It is essential for regulating cellular metabolism and developmental synaptogenesis, cellular migration, differentiation and death. Recent scientific evidences have demonstrated alteration in Glu synthesis and signaling being directly involved in GBM growth and invasion",[67],"Brain Tumor, Primary",[69,70],"Brain tumor","Glutamate","2025-06-06",{"date":73,"type":74},"2025-06-11","ACTUAL",{"date":76,"type":74},"2020-06-01",{"date":78,"type":63},"2029-09-30",{"name":5,"class":6},1]