[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626599":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":28,"responsibleParty":42,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":10,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Josip Juraj Strossmayer University of Osijek","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Chronic Kidney Disease (CKD) group",null,"Patients with CKD of hypertensive etiology, stages 1-2 and 3-5 (eGFR CKD-EPI GFR ≥ 90 ml\u002Fmin\u002F1.73 m², i.e. \\\u003C 60 mL\u002Fmin\u002F1.73 m2), non-diabetics, non-smokers",{"label":13,"type":10,"description":14,"interventionNames":10},"Hypertension (HT) group","Patients who have hypertension (according to ESH2023 Guidelines doi: 10.1097\u002FHJH.0000000000003480) without kidney damage (eGFR CKD-EPI \\>90 mL\u002Fmin\u002F1.73 m2) non-diabetics, non-smokers",{"label":16,"type":10,"description":17,"interventionNames":10},"Normotensive (NT) group","Healthy volunteer subjects as controls",[19],{"name":20,"affiliation":21,"role":22},"Ines Drenjančević, MD, PhD","Faculty of Medicine Josip Juraj Strossmayer University of Osijek","STUDY_CHAIR",[24],{"name":20,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","+385912241406","ines.drenjancevic@mefos.hr",[29],{"facility":30,"status":31,"city":32,"state":10,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":10},"Osijek University Hospital","RECRUITING","Osijek","31000","Croatia","HR",{"type":37,"coordinates":38},"Point",[39,40],18.6942,45.55066,{"lat":40,"lon":39},{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ines Drenjancevic","Head of Department of Physiology and Immunology Faculty of Medicine Osijek","100626599","glycocalyx-and-oxidative-stress-in-endothelial-function-part-1-100626599",false,"NCT07437729","Glycocalyx and Oxidative Stress in Endothelial Function (Part 1)","The Role of Glycocalyx and Oxidative Stress in Endothelial Function (Part 1)","GlikoOxEND","Inclusion Criteria:\n\n* patients with CKD of hypertensive etiology (grades 1-2 and 3-5; eGFR CKD-EPI GFR ≥ 90 ml\u002Fmin\u002F1.73 m², i.e. \\\u003C 60 mL\u002Fmin\u002F1.73 m2), non-diabetics, non-smokers\n* patients with hypertension (according to ESH2023 Guidelines) without kidney damage (eGFR CKD-EPI \\>90 mL\u002Fmin\u002F1.73 m2) non-diabetics, non-smokers\n* healthy volunteer subjects as controls\n\nExclusion Criteria:\n\n* kidney disease of any other etiology except hypertension\n* endocrine, autoimmune or inflammatory diseases that could affect kidney function.\n* smoking\n* diabetes",true,"ALL","18 Years",{"count":58,"type":59},105,"ESTIMATED","OBSERVATIONAL","The primary research objective of the project is to determine the role of eGC in microvascular reactivity in CKD (cross-sectional study 1).\n\nThe main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CKD, as well as identify new biomarkers for CKD.",[63],"Chronic Kidney Disease Patients",[65,66,67,68,69,70],"Glycocalyx","Microcirculation","Endothelium","Inflammation","Oxidative Stress","Renal Insufficiency, Chronic","2026-02-26",{"date":73,"type":74},"2026-03-02","ACTUAL",{"date":76,"type":74},"2025-10-01",{"date":78,"type":59},"2029-09-30",{"name":5,"class":6},1]