[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627687":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":32,"collaborators":10,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":38,"sex":44,"minAge":45,"maxAge":10,"enrollmentInfo":46,"targetDuration":10,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":53,"overallStatus":21,"whyStopped":10,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"Josip Juraj Strossmayer University of Osijek","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Coronary Heart Disease (CHD) patients",null,"Adult patients of both sexes over 18 years of age, undergoing elective coronary artery bypass grafting (CABG) and who provided written informed consent",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Ines Drenjančević, MD, PhD","CONTACT","+385912241406","ines.drenjancevic@mefos.hr",[19],{"facility":20,"status":21,"city":22,"state":10,"zip":23,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":10},"Osijek University Hospital","RECRUITING","Osijek","31000","Croatia","HR",{"type":27,"coordinates":28},"Point",[29,30],18.6942,45.55066,{"lat":30,"lon":29},{"type":33,"investigatorFullName":34,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ines Drenjancevic","Head of Department of Physiology and Immunology Faculty of Medicine Osijek","100627687","glycocalyx-and-oxidative-stress-in-endothelial-function-part-2-100627687",false,"NCT07451873","Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)","The Role of Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)","GlikoOxEND","Inclusion Criteria:\n\n* adult patients of both sexes over 18 years of age\n* Caucasian\n* undergoing elective coronary artery bypass grafting (CABG)\n* provided written informed consent\n\nExclusion Criteria:\n\n* emergency surgery\n* sepsis or severe systemic inflammation before surgery\n* severe renal or hepatic insufficiency\n* immunosuppression\n* serious comorbidities (e.g., active cancer)\n* therapies that could affect oxidative stress (e.g., high doses of corticosteroids)","ALL","18 Years",{"count":47,"type":48},35,"ESTIMATED","OBSERVATIONAL","The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CVD, as well as identify new biomarkers for CVD.",[52],"Coronary Heart Disease",[54,55,56,57,58,59],"Glycocalyx","Inflammation","Oxidative stress","Endothelium","Coronary Artery Disease","Myocardial Revascularization","2026-03-05",{"date":62,"type":63},"2026-03-09","ACTUAL",{"date":65,"type":63},"2025-10-01",{"date":67,"type":48},"2029-09-30",{"name":5,"class":6},1]