[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541126":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":70,"collaborators":73,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":10,"enrollmentInfo":95,"targetDuration":98,"studyType":99,"phases":10,"briefSummary":100,"conditions":101,"keywords":105,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Complejo Hospitalario Universitario de Santiago","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Controls",null,"Patients with\n\nArterial biomechanics values lower than or equal to the 50th percentile of the distribution (measured as carotid stiffness by ultrasound elastography, distensibility and stress, flow velocity and vascular resistance),\n\nAND\n\nAbsence of vascular target organ damage (considered as carotid intima-media thickness \\>0.9 mm, cholesterol plaque, carotid stenosis, carotid-femoral pulse wave velocity \\>10 m\u002Fs, pulse pressure \\>60 mmHg, ankle-Brachial Index \\\u003C0.9 or \\>1.3, hypertensive retinopathy)\n\nAND\n\nAbsence of cardiovascular disease (cardiovascular events, cerebrovascular events, hospital admissions, consultations, death, disability)",{"label":13,"type":10,"description":14,"interventionNames":10},"Cases","Patients with\n\nArterial biomechanics values higher than the 50th percentile of the distribution (measured as carotid stiffness by ultrasound elastography, distensibility and stress, flow velocity and vascular resistance),\n\nOR\n\nPresence of vascular target organ damage (considered as carotid intima-media thickness \\>0.9 mm, cholesterol plaque, carotid stenosis, carotid-femoral pulse wave velocity \\>10 m\u002Fs, pulse pressure \\>60 mmHg, ankle-Brachial Index \\\u003C0.9 or \\>1.3, hypertensive retinopathy)\n\nOR\n\nPresence of cardiovascular disease (cardiovascular events, cerebrovascular events, hospital admissions, consultations, death, disability)",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Nestor Vazquez-Agra, PhD","CONTACT","0034981950000","nestor.vazquez.agra@sergas.es",[22],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Complejo Hospitalario Universitario de Santiago de Compostela","RECRUITING","Santiago de Compostela","A Coruña","15706","Spain","ES",{"type":31,"coordinates":32},"Point",[33,34],-8.54569,42.88052,{"lat":34,"lon":33},[37,39,41,44,46,48,50,52,54,56,58,60,62,64,66,68],{"name":38,"role":18,"phone":19,"phoneExt":10,"email":20},"Nestor Vazquez Agra, PhD",{"name":17,"role":40,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":42,"role":43,"phone":10,"phoneExt":10,"email":10},"Ana-Teresa Marques-Afonso, MD","SUB_INVESTIGATOR",{"name":45,"role":43,"phone":10,"phoneExt":10,"email":10},"Sofia Barbosa-Gouveia, PhD",{"name":47,"role":43,"phone":10,"phoneExt":10,"email":10},"Anton Cruces-Sande, PhD",{"name":49,"role":43,"phone":10,"phoneExt":10,"email":10},"Carla Diaz-Louzao, PhD",{"name":51,"role":43,"phone":10,"phoneExt":10,"email":10},"Iago Carballo, PhD",{"name":53,"role":43,"phone":10,"phoneExt":10,"email":10},"Lucia Barrera-Lopez, MD",{"name":55,"role":43,"phone":10,"phoneExt":10,"email":10},"Adela Lama-López, MD",{"name":57,"role":43,"phone":10,"phoneExt":10,"email":10},"Lucia Gomez-Suarez, MD",{"name":59,"role":43,"phone":10,"phoneExt":10,"email":10},"Ivan Fernandez-Castro, MD",{"name":61,"role":43,"phone":10,"phoneExt":10,"email":10},"Clara Casar-Cocheteux, MD",{"name":63,"role":43,"phone":10,"phoneExt":10,"email":10},"Alvaro Hermida-Ameijeiras, PhD",{"name":65,"role":43,"phone":10,"phoneExt":10,"email":10},"Arturo Gonzalez-Quintela, PhD",{"name":67,"role":43,"phone":10,"phoneExt":10,"email":10},"Antonio Pose-Reino, PhD",{"name":69,"role":43,"phone":10,"phoneExt":10,"email":10},"Francisco Gude-Sampedro, PhD",{"type":40,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Nestor Vazquez Agra","Principal Investigator",[74,77,80,82],{"name":75,"class":76},"Instituto de Investigación Sanitaria de Santiago de Compostela","UNKNOWN",{"name":78,"class":79},"Instituto de Salud Carlos III","OTHER_GOV",{"name":81,"class":6},"University of Santiago de Compostela",{"name":83,"class":76},"Hospital de Barbanza","100541126","glycoxidation-arterial-biomechanics-and-target-organ-damage-100541126",false,"NCT06325800","Glycoxidation, Arterial Biomechanics, and Target Organ Damage","The Role of Glycoxidation on Arterial Biomechanics and Target Organ Damage in Patients With Moderate to High Cardiovascular Risk. The GlycOxiTod Observational Multicentric Registry","GlycOxiTod","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Moderate to high Cardiovascular Risk estimated by SCORE2OP.\n* Signed written consent for participation in the study.\n\nExclusion Criteria:\n\n* Absence of current smoking habit and in the last 6 months.\n* High-risk alcohol consumption (More than 10 and 20 g\u002Fday in women and men, respectively).\n* Presence of Diabetes mellitus.\n* Established cardiovascular disease, including heart failure, ischemic heart disease, valvular heart disease, atrial fibrillation, peripheral artery disease, and cerebrovascular disease.",true,"ALL","18 Years",{"count":96,"type":97},500,"ESTIMATED","5 Years","OBSERVATIONAL","Vascular target organ damage (TOD), defined as structural or functional deleterious changes in large and small arteries, is related to unfavorable arterial biomechanics, atherosclerosis and arteriosclerosis. Endothelial dysfunction due to unfavorable redox and glycation states on the bases of these phenomena. However, little is known about the role of glycoxidation on arterial biomechanics and TOD in apparently healthy individuals. The main hypothesis is that glycation and glycoxidation status are associated with arterial biomechanical abnormalities and TOD in patients with moderate to high cardiovascular risk. This is an observational, ambispective, and multicenter project that will include non-smoking patients over 18 years, without diabetes mellitus or established cardiovascular disease. Demographic, epidemiological, and clinical-anthropometric variables will be collected, including data from ambulatory blood pressure monitoring. The investigators will measure the serum percentage of glycated hemoglobin, glycated albumin, and fructosamine levels; along with quantification of skin advanced glycation and glycoxidation end productos (AGEs). Plasma concentration, activity, and structure of catalase, glutathione peroxidase, and superoxide dismutase in relation to the patient's glycation and glycoxidation status will be also evaluated. Concurrently, several biomechanical parameters will be assessed in the Common, Internal Carotid Artery, and distal limb arteries using ultrasound exploration. Incipient microvasculature damage will be also evaluated by retinal image. Patients will be followed up for the development of arterial biomechanical abnormalities and TOD, along with cardiovascular events.",[102,103,104],"Oxidative Stress","Cardiovascular Risk","Target Organ Damage",[106,107,108,109,110,111],"glycation","antioxidant","target organ damage","arterial biomechanic","carotid","glycoxidation","2024-04-06",{"date":114,"type":115},"2024-04-09","ACTUAL",{"date":117,"type":115},"2024-01-01",{"date":119,"type":97},"2029-12-31",{"name":5,"class":6},1]