[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560004":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":13,"centralContacts":17,"locations":26,"responsibleParty":46,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"University of Missouri-Columbia","OTHER",[8,11],{"label":9,"type":10,"description":10,"interventionNames":10},"Men and women with a family history of type 2 diabetes",null,{"label":12,"type":10,"description":10,"interventionNames":10},"Men and women without a family history of type 2 diabetes",[14],{"name":15,"affiliation":5,"role":16},"Bettina Mittendorfer, PhD","PRINCIPAL_INVESTIGATOR",[18,23],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Amanda Heider","CONTACT","573-884-6852","ahmc4@health.missouri.edu",{"name":24,"role":20,"phone":10,"phoneExt":10,"email":25},"Vasavi Shabrish, PhD","v.shabrish@missouri.edu",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"University of Missouri School of Medicine","RECRUITING","Columbia","Missouri","65212","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-92.33407,38.95171,{"lat":39,"lon":38},[42],{"name":43,"role":20,"phone":44,"phoneExt":10,"email":45},"Bettina Mittendorfer","573-882-9377","b.mittendorfer@missouri.edu",{"type":16,"investigatorFullName":43,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Senior Associate Dean for Research; Professor, Medicine & Nutrition; NextGen Director of Clinical and Translational Sciences Unit","100560004","growth-hormone-resistance-of-beta-cells-in-people-with-a-family-history-of-type-2-diabetes-100560004",false,"NCT06571500","Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes","GHRB-B","Inclusion Criteria:\n\n* 18 to 59 years old\n* body mass index ≥30.0 kg\u002Fm2 and \\\u003C45.0 kg\u002Fm2\n\nAdditional, group-specific inclusion criteria:\n\n* Family history of type 2 diabetes: first degree relative with type 2 diabetes\n* Control group: no family history of type 2 diabetes\n\nExclusion Criteria:\n\n* Pregnant, planning to become pregnant during the study, or breastfeeding\n* Current diagnosis or history of type 1 or type 2 diabetes\n* Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)\n* History of bariatric surgery\n* Known, uncontrolled hypothyroidism\n* History of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment\n* Current cancer or cancer that has been in remission less than 5 years\n* First degree relative with type 1 diabetes diagnosis\n* Evidence of significant anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease)\n* Alcohol use disorder, use of controlled substances, or smoking \\>2 cigarettes per day\n* Greater than 3% weight loss within three months of screening or engaged in regular (≥3 days per week), continuous moderate- or high-intensity exercise of ≥30 min duration\n* Mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent",true,"ALL","18 Years","59 Years",{"count":60,"type":61},30,"ESTIMATED","OBSERVATIONAL","The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a family history of type 2 diabetes at the University of Missouri. Our aim is to advance understanding of how growth hormone affects beta-cells and risk factors for developing type 2 diabetes.",[65,66],"Healthy","Obesity","2026-05-05",{"date":69,"type":70},"2026-05-11","ACTUAL",{"date":72,"type":70},"2025-07-15",{"date":74,"type":61},"2030-09-01",{"name":5,"class":6},1]